Genetic diversity of &lt;i&gt;Plasmodium falciparum&lt;/i&gt; among pregnant women in south-west Nigeria

Oboh, Mary Aigbiremo; Idowu, Emmanuel Taiwo; Oyebola, Muyiwa K; Olukosi, Yetunde A.; Otubanjo, Olubunmi Adetoro; Mafe, M A

doi:10.4314/njpar.v38i1.19

Cited by 5 publications

(8 citation statements)

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“…In both investigations, K1 was the most common msp1 allele, while FC27 was the most common msp2 variant. Despite the fact that Kwara and Kogi states are in the North-Central zone, the genetic distribution pattern seen in the studied villages is similar to that reported in the southern states [28,[32][33][34][35][36]. This could be due to community transmission patterns being influenced by environmental factors.…”

Section: Resultssupporting

confidence: 67%

“…Intense human socioeconomic migration could possibly explain the similar genetic distribution pattern reported in different sections of the Southwest, where RO33 frequency was high, K1 and FC27 were the most common msp1 and msp2 allelomorphs, respectively [36,[40][41][42]. In some groups in the Southwest, however, RO33 or MAD20 was found to be the most common msp1 allele, whereas 3D7 was shown to be the most common msp2 allele [28,[33][34][35]. According to the findings of Oboh et al [34], in a study on malaria transmission among pregnant and non-pregnant women in Lagos, RO33 and 3D7 were the most common msp1 and msp2 allelic families, but only among non-pregnant women.…”

Section: Resultsmentioning

confidence: 88%

“…In some groups in the Southwest, however, RO33 or MAD20 was found to be the most common msp1 allele, whereas 3D7 was shown to be the most common msp2 allele [28,[33][34][35]. According to the findings of Oboh et al [34], in a study on malaria transmission among pregnant and non-pregnant women in Lagos, RO33 and 3D7 were the most common msp1 and msp2 allelic families, but only among non-pregnant women. This is consistent with Funwei et al [28] findings in Oyo urban and rural populations.…”

Section: Resultsmentioning

confidence: 99%

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Genetic diversity of Plasmodium falciparum isolates in Nigeria. A review

Opute

Akinkunmi

Funsho

et al. 2022

Egypt J Med Hum Genet

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Background The complexity of infection in malaria-endemic areas is exacerbated by the presence of genetically diverse Plasmodium falciparum strains. There is a risk that more virulent or drug-resistant versions of the disease may arise. Therefore, we reviewed most reported molecular markers that have been detailed to date in Nigeria. Main body of the abstract In this review, we have summarized the genetic diversity of P. falciparum in Nigeria using the two well-reported genes (msp1 and msp2) as genetic diversity biomarkers. The review includes the findings obtained from research conducted in all major geopolitical regions of the country. We found that MSP-2 infection complexity is generally moderate to high in the North-central region. However, in the South-West, there were several regions where the multiplicity of infection (MOI) was either low or extremely high. Conclusion Understanding how Nigeria's malaria situation fits into various reports on P. falciparum genetic variation can improve treatment and immunization options. This review will be helpful for future treatment strategies that would be tailored to the specific needs of Nigeria's malaria-endemic populations.

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Section: Resultssupporting

confidence: 67%

Section: Resultsmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 99%

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Genetic diversity of Plasmodium falciparum isolates in Nigeria. A review

Opute

Akinkunmi

Funsho

et al. 2022

Egypt J Med Hum Genet

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“…Hence, the development of an effective malaria vaccine that can be readily available to at risk individuals in endemic areas cannot be overestimated. Nevertheless, this initiative is being impeded by the enormous parasite diversity [7-9] which renders the vaccine almost ineffective. In moderate and high transmission areas such as in Africa, the probability of a person being infected with numerous parasite clones at the same time is very high [10-14], These clones/strains are often a reflection of the transmission intensity or endemicity level of an area and as such, impacts the immune system of residing persons.…”

Section: Introductionmentioning

confidence: 99%

Is genetic diversity of Plasmodium falciparum suggestive of malaria endemic zone in West Africa? An attempt to respond by a cross-sectional comparative study between Senegal and Nigeria

Oboh

Ndiaye

Diongue

et al. 2020

Preprint

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Background: Characterization of malaria parasite populations in different endemic settings (from low to high) could be helpful for ascertaining the progress of malaria interventions in endemic settings. The present study aims to compare Plasmodium falciparum parasite population structure between two West African countries with very different level of endemicity using P. falciparum allelic polymorphic markers: msp1 and msp2. Methods: Parasite genomic DNA was extracted from 187 dried blood spot collected from confirmed uncomplicated P. falciparum malaria infected patients in Senegal (94) being at the pre-elimination stage in most part of the country and Nigeria (93) which is still at the control stage. Allelic polymorphism of msp1 and msp2 genes were assessed by nested PCR. Results: In Senegal as well as in Nigeria, K1 and IC3D7 allelic families were the most represented for msp1 and msp2 genes respectively. A higher multiplicity of infection (MOI) was found in both study sites in Senegal (Thies:1.51/2.53; Kedougou:2.2/2.0 for msp 1/2) than from sites in Nigeria (Gbagada: 1.39/1.96; Oredo: 1.35/1.75]). The heterozygosity of msp 1 gene was higher in P. falciparum isolates from Senegal (Thies: 0.62; Kedougou: 0.53) than isolates from Nigeria (Gbagada: 0.55; Oredo: 0.50). In Senegal, K1 alleles were associated with heavy (28) than with moderate (18) infections, in Nigeria however, equal proportions of K1 were observed in both infection types. The IC3D7 subtype allele of the msp 2 family showed high occurrence in heavily infected individuals from both countries (Senegal- 32; Nigeria- 26) than in the moderately infected participants. Conclusion: With the unusual high genetic diversity obtained in low endemic setting in Senegal and low genetic diversity in a high endemic Nigerian setting, multiple holistic approach should be employed in evaluating the actual transmission of a place in order to effectively direct control measures.

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“…Hence, an effective malaria vaccine that can be readily available to at risk individuals in endemic areas remains imperative. Nevertheless, this initiative is being impeded by the enormous parasite diversity [6][7][8], which renders the vaccine almost ineffective in some populations. RTS, S, the only malaria vaccine gives a 30% protection even with multiple booster doses.…”

mentioning

confidence: 99%

Allelic diversity of MSP1 and MSP2 repeat loci correlate with levels of malaria endemicity in Senegal and Nigerian populations

Oboh

Ndiaye

Diongue

et al. 2021

Malar J

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Background Characterizing the genetic diversity of malaria parasite populations in different endemic settings (from low to high) could be helpful in determining the effectiveness of malaria interventions. This study compared Plasmodium falciparum parasite population diversity from two sites with low (pre-elimination) and high transmission in Senegal and Nigeria, respectively. Methods Parasite genomic DNA was extracted from 187 dried blood spot collected from confirmed uncomplicated P. falciparum malaria infected patients in Senegal (94) and Nigeria (93). Allelic polymorphism at merozoite surface protein 1 (msp1) and merozoite surface protein- 2 (msp2) genes were assessed by nested PCR. Results The most frequent msp1 and msp2 allelic families are the K1 and IC3D7 allelotypes in both Senegal and Nigeria. Multiplicity of infection (MOI) of greater that 1 and thus complex infections was common in both study sites in Senegal (Thies:1.51/2.53; Kedougou:2.2/2.0 for msp1/2) than in Nigeria (Gbagada: 1.39/1.96; Oredo: 1.35/1.75]). The heterozygosity of msp1 gene was higher in P. falciparum isolates from Senegal (Thies: 0.62; Kedougou: 0.53) than isolates from Nigeria (Gbagada: 0.55; Oredo: 0.50). In Senegal, K1 alleles was associated with heavy than with moderate parasite density. Meanwhile, equal proportions of K1 were observed in both heavy and moderate infection types in Nigeria. The IC3D7 subtype allele of the msp2 family was the most frequent in heavily parasitaemic individuals from both countries than in the moderately infected participants. Conclusion The unexpectedly low genetic diversity of infections high endemic Nigerian setting compared to the low endemic settings in Senegal is suggestive of possible epidemic outbreak in Nigeria.

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Genetic diversity of <i>Plasmodium falciparum</i> among pregnant women in south-west Nigeria

Cited by 5 publications

References 0 publications

Genetic diversity of Plasmodium falciparum isolates in Nigeria. A review

Genetic diversity of Plasmodium falciparum isolates in Nigeria. A review

Is genetic diversity of Plasmodium falciparum suggestive of malaria endemic zone in West Africa? An attempt to respond by a cross-sectional comparative study between Senegal and Nigeria

Allelic diversity of MSP1 and MSP2 repeat loci correlate with levels of malaria endemicity in Senegal and Nigerian populations

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