Genetic diversity of HLA system in two populations from Colima, Mexico: Colima city and rural Colima

Heterogeneity of Genetic Admixture Determines SLE Susceptibility in Mexican

“…European populations (8 populations): England ∗ , France Lyon ∗ , Germany Essen ∗ , Ireland Northern ( Williams et al, 1999 ; Middleton et al, 2000 ), Italy ∗ , Italy Sardinia ( Grimaldi et al, 2001 ), Netherlands ∗ and Spain ( Enrich et al, 2019 ). Mexican Mestizo populations from Northern Mexico (7 populations): Baja California ( Escobedo-Ruíz et al, 2020 ), Chihuahua ( Pacheco-Ubaldo et al, 2020 ), Colima ( Barquera et al, 2020b ), Durango ( González-Medina et al, 2020 ), Nuevo León ( Barquera et al, 2020a ), Sinaloa ( Clayton et al, 2020 ), and Sonora ( Uribe-Duarte et al, 2020 ). Mexican Mestizo populations from the Center of Mexico (14 populations): Aguascalientes ( Bravo-Acevedo et al, 2020 ), Guanajuato ( Pantoja-Torres et al, 2020 ), Guerrero ( Juárez-Nicolás et al, 2020 ), Jalisco ( Bravo-Acevedo et al, 2020 ), Mexico City Center, Mexico City Western, Mexico City Eastern, Mexico City Southern, Mexico City Northern ( Barquera et al, 2020e ), Michoacán ( Ballesteros-Romero et al, 2020 ), Morelos ( Ortega-Yáñez et al, 2020 ), Nayarit ( Goné-Vázquez et al, 2020 ), Querétaro ( Martínez-Álvarez et al, 2020 ), and San Luis Potosí ( Hernández-Zaragoza et al, 2020 ).…”

“…As mentioned before, HLA haplotypes confer susceptibility or protection in an ethnic-dependent manner ( Vargas-Alarcón et al, 2001 ; Vasconcelos et al, 2009 ; Furukawa et al, 2014 ; Alarcón-Riquelme et al, 2016 ; Molineros et al, 2019 ). In Mexico, susceptibility varies as the ethnic admixture does, the admixture in Mexico is very heterogeneous across the Country, contributing to the disease variability ( Moreno-Estrada et al, 2014 ; Barquera et al, 2020b ). Therefore, the admixture diversity has contributed to the enrichment of susceptibility markers and an ample SLE phenotypes specter in Mexicans ( Salgado-Galicia et al, 2020 ).…”