The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure

Barquera, Rodrigo; Hernández-Zaragoza, Diana Iraíz; Bravo-Acevedo, Alicia; Arrieta-Bolaños, Esteban; Clayton, Stephen; Acuña-Alonzo, Víctor; Martínez-Álvarez, Julio César; López-Gil, Concepción; Adalid-Sáinz, Carmen; Vega-Martínez, María del Rosario; Escobedo-Ruíz, Araceli; Juárez-Cortés, Eva Dolores; Immel, Alexander; Pacheco-Ubaldo, Hanna; González-Medina, Liliana; Lona-Sánchez, Abraham; Lara-Riegos, Julio; Sánchez-Fernández, María Guadalupe de Jesús; Díaz-López, Rosario; Guizar-López, Gregorio Ulises; Medina-Escobedo, Carolina; Arrazola-García, María Araceli; Montiel-Hernández, Gustavo Daniel; Hernández-Hernández, Ofelia; Cruz, Flor del Rocío Ramos-de la; Juárez-Nicolás, Francisco; Pantoja-Torres, Jorge Arturo; Rodríguez-Munguía, Tirzo Jesús; Juárez-Barreto, Vicencio; Escutia-González, Ariadna Berenice; Goné-Vázquez, Isis; Benítez-Arvizu, Gamaliel; Arellano-Prado, Francia Paulina; García-Arias, Víctor Eduardo; Rodríguez-López, Marla Estefanía; Méndez-Mani, Patricia; García-Álvarez, Raquel; González-Martínez, Marisela del Rocío; Aquino-Rubio, Guadalupe; Escareño-Montiel, Néstor; Vázquez-Castillo, Tannya Verónica; Uribe-Duarte, María Guadalupe; Ruíz-Corral, María de Jesús; Ortega-Yáñez, Andrea; Bernal-Felipe, Natalia; Gómez-Navarro, Benjamín; Arriaga-Perea, Agustín Jericó; Martínez-Bezies, Virginia; Macías-Medrano, Rosa María; Aguilar-Campos, Jesús Abraham; Solís-Martínez, Raúl; Serrano-Osuna, Ricardo; Sandoval-Sandoval, Mario J.; Jaramillo-Rodríguez, Yolanda; Salgado-Adame, Antonio; Cruz, Federico Juárez-de la; Novelo-Garza, Bárbara; Pavón-Vargas, María de los Ángeles; Salgado-Galicia, Norma; Bortolini, María Cátira; Gallo, Carla; Bedoya, Gabriel; Rothhammer, Francisco; González‐José, Rolando; Ruiz-Linares, Andrés; Canizales‐Quinteros, Samuel; Romero‐Hidalgo, Sandra; Krause, Johannes; Zúñiga, Joaquı́n; Yunis, Edmond J.; Bekker-Méndez, Carolina; Granados, Julio

doi:10.1016/j.humimm.2020.06.008

Cited by 43 publications

(15 citation statements)

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“…mtDNA lineages found in the individuals from SJN (L1 and L3) have been found, although not highly represented, among modern day Mexicans with mixed ancestry [74,75]. The African HLA haplotypes found in the SJN individuals, or parts of their haplotypes, can be found throughout modern Mexico in frequencies ranging from 0.01% to 2.27% [76]. Alleles HLA-DRB1*07 and HLA-DQB1*02 have been previously found associated with decreased antibody response against HBV and non-responsiveness to HBV vaccination [77,78].…”

Section: Discussionmentioning

confidence: 94%

Origin and Health Status of First-Generation Africans from Early Colonial Mexico

et al. 2020

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Section: Discussionmentioning

confidence: 94%

Origin and Health Status of First-Generation Africans from Early Colonial Mexico

et al. 2020

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“…Some groups are differentiated as Europeans are from East Asians. Seris and Lacandons are good examples ( Infante et al, 1999 ; Barquera et al, 2020c ); these groups are exposed to high levels of genetic drift and isolation. However, the value of including them as Mexican Native American parental populations is that present-day Mexicans’ genetic composition recapitulates ancient Native American substructure, despite the potential homogenizing effect of postcolonial admixture.…”

Section: Discussionmentioning

confidence: 99%

Heterogeneity of Genetic Admixture Determines SLE Susceptibility in Mexican

et al. 2021

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Systemic Lupus Erythematosus (SLE) is an autoimmune inflammatory disorder for which Major Histocompatibility Complex (MHC) genes are well identified as risk factors. SLE patients present different clinical phenotypes, which are partly explained by admixture patterns variation among Mexicans. Population genetic has insight into the high genetic variability of Mexicans, mainly described through HLA gene studies with anthropological and biomedical importance. A prospective, case-control study was performed. In this study, we recruited 146 SLE patients, and 234 healthy individuals were included as a control group; both groups were admixed Mexicans from Mexico City. The HLA typing methods were based on Next Generation Sequencing and Sequence-Based Typing (SBT). The data analysis was performed with population genetic programs and statistical packages. The admixture estimations based on HLA-B and -DRB1 revealed that SLE patients have a higher Southwestern European ancestry proportion (48 ± 8%) than healthy individuals (30 ± 7%). In contrast, Mexican Native American components are diminished in SLE patients (44 ± 1%) and augmented in Healthy individuals (63 ± 4%). HLA alleles and haplotypes’ frequency analysis found variants previously described in SLE patients from Mexico City. Moreover, a conserved extended haplotype that confers risk to develop SLE was found, the HLA-A∗29:02∼C∗16:01∼B∗44:03∼DRB1∗07:01∼DQB1∗02:02, pC = 0.02, OR = 1.41. Consistent with the admixture estimations, the origin of all risk alleles and haplotypes found in this study are European, while the protection alleles are Mexican Native American. The analysis of genetic distances supported that the SLE patient group is closer to the Southwestern European parental populace and farthest from Mexican Native Americans than healthy individuals. Heterogeneity of genetic admixture determines SLE susceptibility and protection in Mexicans. HLA sequencing is helpful to determine susceptibility alleles and haplotypes restricted to some populations.

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“…10 HLA-DR mediated signalling is strongly influenced by the high polymorphism of these molecules. 10 Importantly, the variability and richness of HLA molecules in Mexican Mestizos are strongly influenced by admixture; 11 and in many cases, the introduced and fixed alleles have been responsible for susceptibility to different diseases. However, the specific alleles which generate susceptibility and change signalling in melanoma cells are not yet described for acral lentiginous melanoma.…”

Section: Introductionmentioning

confidence: 99%

Human leukocyte antigen Class II alleles associated with acral lentiginous melanoma in Mexican Mestizo patients: A case-control study

Roldán–Marín¹,

Rangel-Gamboa

Vega‐Memije

et al. 2021

IJDVL

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Background: Melanoma is an aggressive cutaneous cancer. Acral lentiginous melanoma is a melanoma subtype arising on palms, soles, and nail-units. The incidence, prevalence and prognosis differ among populations. The link between expression of major histocompatibility complex Class II alleles and melanoma progression is known. However, available studies report variable results regarding the association of melanoma with specific HLA Class II loci. Aims: The aim of the study was to determine HLA Class II allele frequencies in acral lentiginous melanoma patients and healthy Mexican Mestizo individuals. Methods: Eighteen patients with acral lentiginous melanoma and 99 healthy controls were recruited. HLA Class II typing was performed based on the sequence-specific oligonucleotide method. Results: Three alleles were associated with increased susceptibility to develop acral lentiginous melanoma, namely: HLA-DRB1*13:01; pC = 0.02, odds ratio = 6.1, IC95% = 1.4–25.5, HLA-DQA1*01:03; pC = 0.001, odds ratio = 9.3, IC95% = 2.7–31.3 and HLA-DQB1*02:02; pC = 0.01, odds ratio = 3.7, IC95% = 1.4–10.3. Limitations: The small sample size was a major limitation, although it included all acral lentiginous melanoma patients seen at the dermatology department of Dr. Manuel Gea González General Hospital during the study period. Conclusion: HLA-DRB1*13:01, HLA-DQB1*02:02 and HLA-DQA*01:03 alleles are associated with increased susceptibility to develop acral lentiginous melanoma in Mexican Mestizo patients.

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The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure

Cited by 43 publications

References 145 publications

Origin and Health Status of First-Generation Africans from Early Colonial Mexico

Origin and Health Status of First-Generation Africans from Early Colonial Mexico

Heterogeneity of Genetic Admixture Determines SLE Susceptibility in Mexican

Human leukocyte antigen Class II alleles associated with acral lentiginous melanoma in Mexican Mestizo patients: A case-control study

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