Genetic diversity of HCV among various high risk populations (IDAs, thalassemia, hemophilia, HD patients) in Iran

Rafiei, Ali; Darzyani, Azizi M; Taheri, Saeed; Haghshenas,; Hosseinian, A; Makhlough, Atieh

doi:10.1016/s1995-7645(13)60096-6

Cited by 18 publications

(17 citation statements)

References 29 publications

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“…Genotype 3a was detected as the predominant genotype in Pakistan and was found in 68.1% of patients, followed by genotype 1a as reported in 11.3% of the cases (33); these results were consistent with the present findings. On the other hand, among 187 anti-HCV-positive samples, only 135 (72.19%) cases were HCV-RNA-positive, which is in contrast with the current study (35). Moreover, in another study performed in Isfahan province (Iran), during 2007 -2009, among 146 anti-HCV-positive patients, 97 were determined as HCV-RNA-positive and also the most predominant genotype was genotype 3a (61.2%), followed by genotypes 1a (29.5%), 1b (5.1%) and 2 (2%), respectively (36).…”

Section: Discussioncontrasting

confidence: 99%

The Prevalence of Hepatitis C Virus Genotypes in Mazandaran Province, Iran

Ebrahimzadeh

Haghshenas

Babamahmoodi

2017

Jundishapur J Microbiol

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Background: Hepatitis C virus (HCV) infection is a major public health concern and the third most common cause of death from cancer worldwide. This infection is the most common risk factor for the progression of chronic liver disease, chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Hepatitis C virus infection is classified into six major genotypes and multiple subtypes. The distribution of HCV genotypes seems to vary in different areas around the globe.

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Section: Discussioncontrasting

confidence: 99%

The Prevalence of Hepatitis C Virus Genotypes in Mazandaran Province, Iran

Ebrahimzadeh

Haghshenas

Babamahmoodi

2017

Jundishapur J Microbiol

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“…HCV is distributed throughout the world with varying prevalence rates, affecting about more than 3% of the world's population. This virus can account for approximately 20% of all cases of acute hepatitis, 80% of cases of chronic hepatitis, 40% of cirrhosis cases, 70% of cases of hepatocellular carcinoma, and 30% of cases of liver transplantation (1)(2)(3).…”

Section: Introductionmentioning

confidence: 99%

“…Some groups, such as patients with haemophilia, thalassemia, renal diseases (under hemodialysis), and intravenous drug use are at a high risk of HCV infection. No vaccine is available against HCV infection, and the accessible antiviral drugs are long-acting, difficult to use, expensive, and ineffective for patients (1)(2)(3).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Hepatitis C Virus Antibodies among Beta-Thalassemia Major Patients in Kurdistan Province, Iran

Mohammadi

Khodabandehloo

2017

Arch Clin Infect Dis

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Background: Blood transfusion is used to treat patients with beta-thalassemia major. Blood transfusion is associated with risk of infection, especially hepatitis C virus (HCV). Objectives: The aim of this study was to determine the prevalence of anti-HCV antibodies in patients with beta-thalassemia major in Kurdistan, Iran. Methods: In this cross sectional study, serum samples were collected from 106 out of 129 registered patients with beta-thalassemia major, referred to hospitals in Kurdistan province, Iran in 2015. The sera were kept at -20°C until analysis. Antibodies to HCV (IgG and IgM) were determined using enzyme-linked immunosorbent assay (ELISA); ELISA-positive samples were verified by the recombinant immunoblot assay (RIBA). Results: The prevalence of anti-HCV antibodies was 5.66% (4 males, 2 females), based on the ELISA assay. Four (3.77%) ELISA-positive patients were confirmed by RIBA assay (2 males, 2 females), while the results of 2 (1.88%) men were indeterminate. HCV antibodies showed a significant correlation with the patient's age (P = 0.001) and duration of receiving blood transfusions (P = 0.003). However, there was no significant association between HCV antibodies and gender (P = 0.428). Conclusions:The prevalence of HCV in patients with beta-thalassemia major was lower in Kurdistan, compared to other provinces of Iran. Although screening programs for blood donors in blood transfusion centers can be effective, it is recommended to use nucleic acid tests for screening blood donors.

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“…Viral diseases including hepatitis B, hepatitis C, and acquired immune deficiency syndrome are of special interest. Patients with hemophilia, thalassemia and hemodialysis have a higher risk of acquiring these transfusion-associated viral infections due to the large number of blood transfusions and products received (Rezvan et al 2007;Rafiei et al 2013). In the present study, we investigated the prevalence of HBV, HCV, and HIV infections among 580 hemophilia patients in Shiraz, south of Iran.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of hepatitis B, hepatitis C, and human immunodeficiency virus infections among hemophilia patients in Shiraz, south of Iran

et al. 2016

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Transfusion-transmitted viral infections, including hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV) infections continue to be a major challenge in hemophilia patient. This study was conducted to assess the seroprevalence of HBV, HCV, and HIV infections among Iranian hemophilia patients. A cross-sectional study was conducted on 580 hemophilia patients (mean age ± SD = 27.11 ± 14.9) referred to the Namazi hospital, Shiraz University of medical sciences, Shiraz, Iran during July 2012 to August 2015. Blood samples were taken from the patients and tested for HBV surface antigen (HBsAg), antibody to HBV surface antigen (anti-HBs), antibody to HBV core antigen (anti-HBc), anti-HCV antibody (HCVAb), and anti-HIV antibody (HIVAb). The association of HBV, HCV, and HIV infections with age, sex, type of hemophilia (A or B), severity of hemophilia, blood group system, history of blood transfusion, and surgery were statistically analyzed using SPSS software and chi-square/Fisher exact tests. The seroprevalence of HCVAb and HBsAg were 11.4 % (66/ 580) and 0.2 % (1/580), respectively. None of the hemophilia patients were positive for HIV antibody. There was a significant association between HCV seropositivity and age (P < 0.001), severity of hemophilia (P < 0.0001), and history of blood transfusion (P = 0.050). It seems that strategies for prevention of HBV and HIV infections have been successful in south of Iran, but HCV is still a major infection of concern in multi-transfused patients.

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Genetic diversity of HCV among various high risk populations (IDAs, thalassemia, hemophilia, HD patients) in Iran

Cited by 18 publications

References 29 publications

The Prevalence of Hepatitis C Virus Genotypes in Mazandaran Province, Iran

The Prevalence of Hepatitis C Virus Genotypes in Mazandaran Province, Iran

Prevalence of Hepatitis C Virus Antibodies among Beta-Thalassemia Major Patients in Kurdistan Province, Iran

Prevalence of hepatitis B, hepatitis C, and human immunodeficiency virus infections among hemophilia patients in Shiraz, south of Iran

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