Genetic diversity of bovine viral diarrhoea virus (BVDV) from Peru and Chile

Ståhl, Karl; Benito, Alfredo A.; Felmer, Ricardo; Zúñiga, Juan José Romero; Reinhardt, G.; Rivera, G Hermelinda; Baule, Claudia; Moreno‐López, J.

doi:10.1590/s0100-736x2009000100006

Cited by 13 publications

(7 citation statements)

References 28 publications

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“…BVDV-1a (cases 1, 5, and 6) and BVDV-2b (cases 3 and 4) were identified in heifers/steers in our work, indicating that both species are related to postnatal morbidity and mortality in cattle in Uruguay. In other South American countries, clinical disease has been reported for BVDV-1a, BVDV-1b, BVDV-2a, and BVDV-2b in Argentina [44][45][46]; BVDV-1b, BVDV-1d, BVDV-1i, and BVDV-2b in Brazil [47][48][49][50]; and BVDV-1a, BVDV-1b, and BVDV-1c in Chile and Peru [17,51]. Although cattle exposed to BVDV in utero constitute a significant portion of clinical presentations, cases of transient/acute postnatal infection may be significant sources of direct losses [1].…”

Section: Discussionmentioning

confidence: 99%

“…As viruses with worldwide distribution [9], BVDV-1 and BVDV-2 have been recognized for many years in South American countries, including Brazil [14], Argentina [15], Colombia [16], Peru, Chile [17], and Uruguay [18], while the Pestivirus HoBi-like virus has currently only been identified in Argentina [19] and Brazil [20] on this subcontinent. In Uruguay, the first evidence of BVDV circulation dates from 1996 [21].…”

Section: Introductionmentioning

confidence: 99%

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Diseases associated with bovine viral diarrhea virus subtypes 1a and 2b in beef and dairy cattle in Uruguay

et al. 2019

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Bovine viral diarrhea virus (BVDV, Pestivirus) causes significant economic losses to the livestock industry worldwide. Although serological surveys show that BVDV exposure is widespread in cattle in Uruguay, BVDV-associated diseases are greatly underreported. The aim of this work is to describe the epidemiological, clinical, pathological, and virological findings from spontaneous outbreaks of BVDV-associated diseases in cattle in Uruguay. Diagnostic investigations were performed during 6 spontaneous disease outbreaks on beef and dairy cattle farms in the departments of Colonia, Rio Negro, and Soriano between November 2016 and April 2018. Carcasses of 8 naturally deceased cattle from these outbreaks were necropsied and subjected to histological examination and immunohistochemistry to detect BVDV antigen in the tissues. Reverse transcription real-time PCR and genomic sequencing were also performed to identify BVDV at the species and subtype levels. Other ancillary diagnostic tests, including bacterial cultures, were performed on a case-by-case basis to rule in/out differential diagnoses based on initial clinicopathological presumptive diagnoses. BVDV-associated conditions that were diagnosed in the 8 cases included mucosal disease, transient postnatal BVDV infections associated with digestive/septicemic salmonellosis by Salmonella serovar typhimurium, Histophilus somni bronchopneumonia, urinary tract coinfections with Escherichia coli and Streptococcus sp., enteric coinfection with coccidia, and transplacental fetal infections and abortions with Neospora caninum coinfection. BVDV-1a and BVDV-2b were each identified in four of the eight cases. We conclude that BVDV-1a and BVDV-2b contribute significantly to disease and mortality in cattle in Uruguay. Future research should estimate the economic impact of BVDV in the Uruguayan livestock sector.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diseases associated with bovine viral diarrhea virus subtypes 1a and 2b in beef and dairy cattle in Uruguay

et al. 2019

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“…: Genotyping was not performed. References (I): [ 48 , 49 , 50 , 51 , 52 ]; (II): [ 7 , 43 , 49 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ]; (III): [ 59 , 60 ]; (IV): [ 39 , 44 , 49 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 ]; (V): [ 49 , 71 ]; (VI): [ 72 ]. In [ 57 ] the year of virus isolation was not displayed in the study.…”

Section: Figurementioning

confidence: 99%

Variability and Global Distribution of Subgenotypes of Bovine Viral Diarrhea Virus

Yeşilbağ

Alpay

Becher

2017

Viruses

190

221

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Bovine viral diarrhea virus (BVDV) is a globally-distributed agent responsible for numerous clinical syndromes that lead to major economic losses. Two species, BVDV-1 and BVDV-2, discriminated on the basis of genetic and antigenic differences, are classified in the genus Pestivirus within the Flaviviridae family and distributed on all of the continents. BVDV-1 can be segregated into at least twenty-one subgenotypes (1a–1u), while four subgenotypes have been described for BVDV-2 (2a–2d). With respect to published sequences, the number of virus isolates described for BVDV-1 (88.2%) is considerably higher than for BVDV-2 (11.8%). The most frequently-reported BVDV-1 subgenotype are 1b, followed by 1a and 1c. The highest number of various BVDV subgenotypes has been documented in European countries, indicating greater genetic diversity of the virus on this continent. Current segregation of BVDV field isolates and the designation of subgenotypes are not harmonized. While the species BVDV-1 and BVDV-2 can be clearly differentiated independently from the portion of the genome being compared, analysis of different genomic regions can result in inconsistent assignment of some BVDV isolates to defined subgenotypes. To avoid non-conformities the authors recommend the development of a harmonized system for subdivision of BVDV isolates into defined subgenotypes.

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“…The BVDV-1b subgenotype is one of the most prevalent subgenotypes in cattle in Chile. It is divided into two groups: one group containing only viruses isolated from Chilean cattle (CHL group) and the other group containing viruses isolated from cattle of Chile and other countries (INT group) [ 29 ]. Interestingly, the nucleotide sequence from the Pudú-Chillan isolate belongs to the INT group, and the nucleotide sequence from the Pudú-Zoo isolate belongs to the CHL group (Fig.…”

Section: Discussionmentioning

confidence: 99%

Detection of persistent pestivirus infection in pudú (Pudu puda) in a captive population of artiodactyls in Chile

Salgado

Hidalgo-Hermoso²,

Pizarro-Lucero

2018

BMC Vet Res

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BackgroundBovine Viral Diarrhea Virus (BVDV) is the viral agent causing the most important economic losses in livestock throughout the world. Infection of fetuses before their immunological maturity causes the birth of animals persistently infected with BVDV (PI), which are the main source of infection and maintenance of this pathogen in a herd. There is evidence of susceptibility to infection with BVDV in more than 50 species of the order Artiodactyla, and the ability to establish persistent infection in wild cervid species of South America could represent an important risk in control and eradication programs of BVDV in cattle, and a threat to conservation of these wild species. In this study, a serological and virological study was performed to detect BVDV infection in a captive population of non-bovine artiodactyl species in a Chilean zoo with antecedents of abortions whose pathology suggests an infectious etiology.ResultsDetection of neutralizing antibodies against BVDV was performed in 112 artiodactyl animals from a zoo in Chile. Three alpacas (Vicugna pacos), one guanaco (Lama guanicoe) and seven pudús (Pudu puda) resulted seropositive, and the only seronegative pudú was suspected to be persistently infected with BVDV. Then two blood samples nine months apart were analyzed by a viral neutralization test and RT-PCR. Non-cytopathogenic BVDVs were isolated in both samples. A phylogenetic analysis showed that the virus was highly related to BVDV-1b strains circulating among Chilean cattle.ConclusionsThis is the first report of a South American deer persistently infected with Bovine Viral Diarrhea Virus. Further studies are needed to determine the possible role of BVDV as a pathogen in pudús and as a threat to their conservation.

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Genetic diversity of bovine viral diarrhoea virus (BVDV) from Peru and Chile

Cited by 13 publications

References 28 publications

Diseases associated with bovine viral diarrhea virus subtypes 1a and 2b in beef and dairy cattle in Uruguay

Diseases associated with bovine viral diarrhea virus subtypes 1a and 2b in beef and dairy cattle in Uruguay

Variability and Global Distribution of Subgenotypes of Bovine Viral Diarrhea Virus

Detection of persistent pestivirus infection in pudú (Pudu puda) in a captive population of artiodactyls in Chile

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