Genetic diversity and tetracycline resistance genes of Histophilus somni

D’Amours, Geneviève H.; Ward, Tracy I.; Mulvey, Michael R.; Read, Ronald R.; Morck, Douglas W.

doi:10.1016/j.vetmic.2011.02.051

Cited by 19 publications

(14 citation statements)

References 25 publications

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“…2). This supports previous studies suggesting there is limited genetic diversity in H. somni isolates and that the main mode of dispersal is clonal expansion (D'Amours et al, 2011). In our study, 51% of H. somni isolates belonged to cluster 6; within this cluster, clonal group 6.3 contained 56% of isolates.…”

Section: Discussionsupporting

confidence: 91%

Antimicrobial susceptibility of Histophilus somni isolated from clinically affected cattle in Australia

Goldspink

Mollinger

Barnes

et al. 2015

The Veterinary Journal

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Section: Discussionsupporting

confidence: 91%

Antimicrobial susceptibility of Histophilus somni isolated from clinically affected cattle in Australia

Goldspink

Mollinger

Barnes

et al. 2015

The Veterinary Journal

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“…Culture has the advantage of providing the laboratory isolates for use in antimicrobial susceptibility assays, MALDI-TOF mass spectroscopic characterization, other comparative analyses, and epidemiological studies (Tegtmeier et al 2000;Portis et al 2012;Kuhnert et al 2012;Frey and Kuhnert 2015). Antimicrobial susceptibility assays for H. somni include disk diffusion (Kirby-Bauer, Edisk) and broth microdilution (D'Amours et al 2011;Goldspink et al 2015). H. somni is susceptible to multiple antimicrobial classes in vitro.…”

Section: Laboratory Diagnosis and Antimicrobial Resistance Testingmentioning

confidence: 99%

“…Susceptibility to individual antimicrobials includes ceftiofur, penicillin, enrofloxacin, and florfenicol. Resistance to tetracyclines is emerging in the USA and Australia (D'Amours et al 2011;Portis et al 2012).…”

Section: Laboratory Diagnosis and Antimicrobial Resistance Testingmentioning

confidence: 99%

Histophilosis as a Natural Disease

O’Toole

Sondgeroth

2015

Current Topics in Microbiology and Immunology

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Histophilus somni is responsible for sporadic disease worldwide in cattle and, to a lesser extent, in small ruminants, bighorn sheep (Ovis canadensis), and North American bison (Bison bison). The importance of H. somni diseases can be attributed to improved clinical and laboratory recognition, combined with the growth in intensive management practices for cattle. Although outbreaks of bovine histophilosis can occur year-round, in northern and southern hemispheres, it is most frequent in late fall and early winter. Weather, stress, dietary changes, and comingling of cattle are likely to be major triggers for outbreaks. The most frequent clinical expressions of histophilosis include undifferentiated fever, fibrinosuppurative pneumonia, encephalitis-leptomeningitis, necrotizing myocarditis, and diffuse pleuritis. Neurological disease occurs either as thrombotic meningoencephalitis (TME) or as suppurative meningitis with ventriculitis. Acute myocarditis is characteristically necrotizing and generally involves one or both papillary muscles in the left ventricular myocardium. Biofilm-like aggregates of bacteria occur in capillaries and veins in myocardium, in the central nervous system, and on endocardial surfaces. H. somni is a component of bovine respiratory disease (BRD) complex. In our experience, it is most commonly diagnosed in subacute-to-chronic polymicrobial pulmonary infections in combination with Mannheimia haemolytica, Trueperella pyogenes, Pasteurella multocida, or Mycoplasma bovis. Other, less common forms of H. somni disease present as polyarthritis/tenosynovitis, abortion with placentitis and fetal septicemia, epididymitis-orchitis, and ocular infections. It is likely that H. somni is under-recognized clinically and diagnostically. Most state and provincial laboratories in North America rely on bacterial isolation to confirm infection. The use of more sensitive detection methods on field cases of histophilosis will help resolve the pathogenesis of H. somni in natural outbreaks, and whether the disease is as common elsewhere as it is in Canada.

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“…Similar publications specific for pathogens of BRD did not begin appearing in the literature until the early 1980s. Resistance genes have been found and described for the common bacterial pathogens associated with BRD for the tetracyclines (Singer et al, 1998;Kehrenberg et al, 2005;O'Connor et al, 2010;D'Amours et al, 2011;Klima et al, 2011;Michael et al, 2012b), fluoroquinolones (Michael et al, 2012b;Pardon et al, 2013), beta-lactams ( Klima et al, 2011;Michael et al, 2012b;Alexander et al, 2013a), macrolides (Desmolaize et al, 2011a, b;Kadlec et al, 2011;Klima et al, 2011;Michael et al, 2012b), sulfonamides (Michael et al, 2012b), lincosamides (Desmolaize et al, 2011b;Kadlec et al, 2011;Michael et al, 2012b), phenicols (Kehrenberg et al, 2008;Katsuda et al, 2012;Michael et al, 2012b), and aminoglycosides (Michael et al, 2012b;Alexander et al, 2013a). Lubbers and Hanzlicek described the available literature on antimicrobial resistance by categorizing the information into two categories: (1) authors reporting the percentage of isolates that are susceptible or resistant, or (2) the minimal inhibitory concentration (MIC) distribution, i.e.…”

Section: Introductionmentioning

confidence: 99%

A literature review of antimicrobial resistance in Pathogens associated with bovine respiratory disease

DeDonder

Apley

2015

Anim. Health. Res. Rev.

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The objective of this paper was to perform a critical review of the literature as it pertains to the current status of antimicrobial resistance in pathogens associated with bovine respiratory disease (BRD) in beef cattle and to provide a concise yet informative narrative on the most relevant publications available. As such, the scientific literature contained in PubMed, AGRICOLA, and CAB were searched in February of 2014 for articles related to susceptibility testing of Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni from cases of BRD. Titles and abstracts were read and 105 articles that were relevant to the subject of BRD antibiotic resistance were attained for further review. After the application of exclusion criterion (publications must have originated from North America, be in English, adhere to standards set forth by the Clinical and Laboratory Standards Institute, and be concerning antimicrobial resistance in BRD in beef cattle), 16 articles remained and are the focus of this publication. Due to the disparate data from the few studies that investigate susceptibility testing of BRD pathogens, a quantitative assessment or meta-analysis was not performed on the studies presented in this review. However, considering diagnostic lab data, there appears to be a clear trend of a decrease in susceptibility of the three major BRD pathogens to the antimicrobials used commonly for treatment and control of BRD. Studies performing sensitivity testing on healthy cattle report much lower resistance, but it remains unclear if this is because of a true lack of resistance mechanisms, or if the isolates do contain quiescent genes for resistance that are only phenotypically expressed following the administration of an antimicrobial for either treatment or control of BRD. Future research to address this question of genotype and phenotypic expression before and after antimicrobial administration will further advance our knowledge in this area.

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Genetic diversity and tetracycline resistance genes of Histophilus somni

Cited by 19 publications

References 25 publications

Antimicrobial susceptibility of Histophilus somni isolated from clinically affected cattle in Australia

Antimicrobial susceptibility of Histophilus somni isolated from clinically affected cattle in Australia

Histophilosis as a Natural Disease

A literature review of antimicrobial resistance in Pathogens associated with bovine respiratory disease

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