Genetic Diversity and Phylogeny of Aedes aegypti, the Main Arbovirus Vector in the Pacific

Calvez, Elodie; Guillaumot, Laurent; Millet, Laurent; Marie, Jérôme; Bossin, Hervé; Rama, Vineshwaran; Faamoe, Akata; Kilama, Sosiasi; Teurlai, Magali; Mathieu-Daudé, Françoise; Dupont‐Rouzeyrol, Myrielle

doi:10.1371/journal.pntd.0004374

Cited by 66 publications

(71 citation statements)

References 49 publications

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“…aegypti, the main vector of DENV (296,297), and Aedes polynesiensis, the main vector of lymphatic filariasis in this country (298,299); Ae. hensilii and Ae.…”

Section: Vectors and Vector-borne Transmissionmentioning

confidence: 99%

Zika Virus

2016

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SUMMARYZika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the genusFlavivirusand the familyFlaviviridae. ZIKV was first isolated from a nonhuman primate in 1947 and from mosquitoes in 1948 in Africa, and ZIKV infections in humans were sporadic for half a century before emerging in the Pacific and the Americas. ZIKV is usually transmitted by the bite of infected mosquitoes. The clinical presentation of Zika fever is nonspecific and can be misdiagnosed as other infectious diseases, especially those due to arboviruses such as dengue and chikungunya. ZIKV infection was associated with only mild illness prior to the large French Polynesian outbreak in 2013 and 2014, when severe neurological complications were reported, and the emergence in Brazil of a dramatic increase in severe congenital malformations (microcephaly) suspected to be associated with ZIKV. Laboratory diagnosis of Zika fever relies on virus isolation or detection of ZIKV-specific RNA. Serological diagnosis is complicated by cross-reactivity among members of theFlavivirusgenus. The adaptation of ZIKV to an urban cycle involving humans and domestic mosquito vectors in tropical areas where dengue is endemic suggests that the incidence of ZIKV infections may be underestimated. There is a high potential for ZIKV emergence in urban centers in the tropics that are infested with competent mosquito vectors such asAedes aegyptiandAedes albopictus.

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“…aegypti, the main vector of DENV (296,297), and Aedes polynesiensis, the main vector of lymphatic filariasis in this country (298,299); Ae. hensilii and Ae.…”

Section: Vectors and Vector-borne Transmissionmentioning

confidence: 99%

Zika Virus

2016

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“…Several studies indicate that the most important mosquitoes in this transmission are Aedes aegypti, although there is already much evidence of Aedes albopictus participation in this process [9,10].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Zika Virus by Marine Algae

Cirne-Santos

Barros

Nogueira

et al. 2017

Preprint

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For many years marine algae has been subject of numerous researches and as a source of natural products with antiviral activity, such as terpenes, alkaloids and sulphated polysaccharides. However, the anti-Zika virus (ZIKV) potential of algae has not been studied. In this study we evaluated extracts seven species of the three major classes of seaweeds (Phaeophyceae, Chlorophyceae and Rhodophyceae) against ZIKV. All seaweeds tested are native of the Brazilian coast, except for Kappaphycus alvarezii that can be cultivated. ZIKV a mosquito-borne flavivirus, has become a public health problem. In recent years there has been an increase in the number of cases and a strong association between ZIKV outbreak and the spread of cases of Guillain-Barré Syndrome and microcephaly. All seaweed extracts tested in this work inhibits ZIKV replication in a dose-dependent manner. Caulerpa racemosa, Kappaphycus alvarezii and Osmundaria obtusiloba extracts were able to inhibit viral replication at low concentrations with EC50 values ranging from 1.38 to 1.98 µg/mL. We observed that O. obtusiloba presented a significant virucidal effect. Our results suggest that extracts of C. racemosa, K. alvarezii and O. obtusiloba presented very promising results, being excellent candidates for further studies, demonstrating that marine algae are an interesting source for the development of novel anti-ZIKV agents.

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“…Subsequent outbreaks in French Polynesia (2013-2014), Pacific islands and Brazil (2015), have shown the propensity of ZIKV to spread outside its usual geographical range [37][38][39][40][41]. Aedes aegypti was considered to be major epidemic vector outside Africa [42]. For the first time, ZIKV was detected in Ae.…”

Section: Introductionmentioning

confidence: 99%

An overview of mosquitoes and emerging arboviral infections in the Zagreb area, Croatia

Klobučar

Benić

Krajcar

et al. 2016

J Infect Dev Ctries

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Mosquito control in the Zagreb area has been conducted for many years, whereas the fauna has only been investigated in the last 20 years. So far 30 mosquito species have been detected in the city area. Culex pipiens form molestus is the dominant mosquito species in indoor breeding sites. In forested areas and areas exposed to flooding, the active period is early spring and the dominant species are Ochlerotatus sticticus, Ochlerotatus cantans, Ochlerotatus geniculatus and Aedes vexans. The eudominant mosquito species found in the artificial breeding sites are Culex pipiens and the Asian tiger mosquito, Aedes albopictus. Invasive Ae. albopictus, present in the Zagreb area since 2004, has expanded to a larger area of the city during the last three years. The recent emergence of the human West Nile virus and Usutu virus neuroinvasive disease in Zagreb and its surroundings highlighted the role of mosquitoes as vectors of emerging arboviruses. The paper focuses on mosquito species and arboviral infections detected in humans and animals in the Zagreb area, Croatia.

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Genetic Diversity and Phylogeny of Aedes aegypti, the Main Arbovirus Vector in the Pacific

Cited by 66 publications

References 49 publications

Zika Virus

Zika Virus

Inhibition of Zika Virus by Marine Algae

An overview of mosquitoes and emerging arboviral infections in the Zagreb area, Croatia

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