Genetic Diversity and Azole Resistance Among Natural Aspergillus fumigatus Populations in Yunnan, China

Zhou, Duanyong; Wang, Ruirui; Li, Xiao; Peng, Bin; Yang, Guangzhu; Zhang, Ke‐Qin; Zhang, Ying; Xu, Jianping

doi:10.1007/s00248-021-01804-w

Cited by 9 publications

(21 citation statements)

References 63 publications

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“…However, evidence for recombination was also found in both regional populations. Our results are similar to those reported previously for other regional populations of A. fumigatus [ 18 , 29 , 33 , 34 , 35 ] as well as other human pathogenic and non-pathogenic fungi [ 36 ].…”

Section: Discussionsupporting

confidence: 92%

“…The high level of allelic and genotypic diversity observed within both the Iceland and NWT populations resemble that seen within most regional A. fumigatus populations [ 18 , 29 , 33 , 34 , 35 ]. The high allelic and genotypic diversities within both populations ( Table 2 ) suggested that either these two populations were ancient or that there had been multiple migrations from other regions to these two arctic regions.…”

Section: Discussionmentioning

confidence: 61%

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Genetic Diversity and Dispersal of Aspergillus fumigatus in Arctic Soils

Korfanty

Dixon

Jia

et al. 2021

Genes

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Aspergillus fumigatus is a saprophytic mold and an opportunistic pathogen with a broad geographic and ecological distribution. A. fumigatus is the most common etiological agent of aspergillosis, affecting over 8,000,000 individuals worldwide. Due to the rising number of infections and increasing reports of resistance to antifungal therapy, there is an urgent need to understand A. fumigatus populations from local to global levels. However, many geographic locations and ecological niches remain understudied, including soil environments from arctic regions. In this study, we isolated 32 and 52 A. fumigatus strains from soils in Iceland and the Northwest Territories of Canada (NWT), respectively. These isolates were genotyped at nine microsatellite loci and the genotypes were compared with each other and with those in other parts of the world. Though significantly differentiated from each other, our analyses revealed that A. fumigatus populations from Iceland and NWT contained evidence for both clonal and sexual reproductions, and shared many alleles with each other and with those collected from across Europe, Asia, and the Americas. Interestingly, we found one triazole-resistant strain containing the TR34 /L98H mutation in the cyp51A gene from NWT. This strain is closely related to a triazole-resistant genotype broadly distributed in India. Together, our results suggest that the northern soil populations of A. fumigatus are significantly influenced by those from other geographic regions.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 61%

Genetic Diversity and Dispersal of Aspergillus fumigatus in Arctic Soils

Korfanty

Dixon

Jia

et al. 2021

Genes

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“…A survey on greenhouses around Kunming City revealed that about 80% of A. fumigatus strains in these greenhouses were resistant to at least one triazole drug, with more than 30% demonstrating cross-resistance to ITC and VRC (Zhou et al 2021 ). In Yunnan, among A. fumigatus strains from 19 different geographical regions, the proportion of triazole-resistant A. fumigatus was 15.89% (58/365) (Zhou et al 2022 ). In Lake Dian, the proportion of triazole-resistant A. fumigatus is even higher, reaching 42.9%.…”

Section: Discussionmentioning

confidence: 99%

Isolation of triazole-resistant Aspergillus fumigatus harbouring cyp51A mutations from five patients with invasive pulmonary aspergillosis in Yunnan, China

Xu,

Gao,

Liang

et al. 2024

Mycology

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Invasive aspergillosis (IA) is the most severe type of Aspergillus infection. Yunnan has developed agriculture, and the proportion of triazole-resistant A. fumigatus induced by triazole fungicides is much higher than that in other regions of China. Inhalation of triazole-resistant A. fumigatus is one of the main factors inducing IA. We gathered five strains of A. fumigatus from the sputum or bronchoalveolar lavage fluid (BALF) of patients with IA in Yunnan. Subsequent testing showed that all of these strains were resistant to triazoles and harboured mutations in the tandem repeat sequence of the cyp51A promoter region, suggesting that they may be triazole-resistant A. fumigatus present in the environment.

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“…In this study, the azoles are comparatively less susceptible than polyenes and flucytosine. The high resistance to azole might be due to its inappropriate usage in agriculture and clinical settings in China (Zhou et al, 2022). Moreover, the Year-wise antifungal susceptibility patterns of Candida albicans against all tested drugs.…”

Section: Discussionmentioning

confidence: 99%

Antifungal susceptibility pattern of Candida isolated from cutaneous candidiasis patients in eastern Guangdong region: A retrospective study of the past 10 years

Bilal

Hou²,

Shafiq

et al. 2022

Front. Microbiol.

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Cutaneous candidiasis is one of the most prevalent mycotic infections caused by Candida species. The severity of infection mounts faster when the species shows antifungal resistance. In the current retrospective study, we aimed to analyze the occurrence, causes of cutaneous candidiasis, and antifungal susceptibility pattern of Candida isolates from Skin and Venereal Diseases Prevention and Control Hospital of Shantou, located in eastern Guangdong, China. The laboratory data of all patients (n = 3,113) suffering from various skin and venereal infections during January 2012 to December 2021 was analyzed through Excel and GraphPad prism. Our analysis indicate that cutaneous candidiasis was 22.29% (n = 694), of which 78.53% (n = 554) of patients were males and 21.47% (n = 149) of patients were females. The median age of patients with cutaneous candidiasis was 38-year [interquartile range (30–48)]. Most cases occurred in the adult age group (19–50 years). Regarding the species type, the Candida albicans were prominently detected (n = 664, 95.68%), while non-C. albicans were found only in 30 (4.32%) patients, which were C. glabrata (n = 18), C. krusei (n = 8), C. tropicalis (n = 3), and C. parapsilosis (n = 1). The C. albicans susceptibility rate for terbinafine, miconazole, voriconazole, itraconazole, fluconazole, ketoconazole, nystatin, 5-flucytosine and amphotericin B were 10.83, 29.32, 59.39, 78.53, 85.28, 87.75, 99.59, 99.41, and 100%, respectively. Finally, all C. glabrata isolates were found susceptible to all tested azole drugs with exception to miconazole against which 8.33% of isolates showed resistance. The findings of this study will help healthcare officials to establish better antifungal stewardship in the region.

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Genetic Diversity and Azole Resistance Among Natural Aspergillus fumigatus Populations in Yunnan, China

Cited by 9 publications

References 63 publications

Genetic Diversity and Dispersal of Aspergillus fumigatus in Arctic Soils

Genetic Diversity and Dispersal of Aspergillus fumigatus in Arctic Soils

Isolation of triazole-resistant Aspergillus fumigatus harbouring cyp51A mutations from five patients with invasive pulmonary aspergillosis in Yunnan, China

Antifungal susceptibility pattern of Candida isolated from cutaneous candidiasis patients in eastern Guangdong region: A retrospective study of the past 10 years

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