Genetic Disorders of Neonatal Respiratory Function

Cole, F. Sessions; Hamvas, Aaron; Nogee, Lawrence M.

doi:10.1203/00006450-200108000-00001

Cited by 82 publications

(40 citation statements)

References 82 publications

(54 reference statements)

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“…This mixture forms a monolayer at the air-liquid interface which lowers the surface tension, stabilizes alveoli and terminal airways at low lung volume and prevents alveolar collapse at the end of the expiration. Treatment with synthetic or naturally developed surfactant has been associated with a decline in the mortality of RDS among premature infants (3,4).…”

Section: R Espiratory Distress Syndrome (Rds) Is a Main Contributormentioning

confidence: 99%

Surfactant Protein D Levels in Umbilical Cord Blood and Capillary Blood of Premature Infants. The Influence of Perinatal Factors

et al. 2006

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Surfactant protein D (SP-D) is a collectin that plays an important role in the innate immune system and takes part in the surfactant homeostasis by regulating the surfactant pool size. The aims of this study were to investigate the values of SP-D in umbilical cord blood and capillary blood of premature infants and to relate the levels to perinatal conditions. A total of 254 premature infants were enrolled in the present study. Umbilical cord blood was drawn at the time of birth and capillary blood at regular intervals throughout the admission. The concentration of SP-D in umbilical cord blood and capillary blood was measured using ELISA technique. The median concentration of SP-D in umbilical cord blood was twice as high as in mature infants, 769 ng/mL (range 140 -2,551), with lowest values in infants with intrauterine growth retardation (IUGR) and rupture of membranes (ROM). The median concentration of SP-D in capillary blood day 1 was 1,466 ng/mL (range 410 -5,051 ng/mL), with lowest values in infants born with ROM and delivered vaginally. High SP-D levels in umbilical cord blood and capillary blood on day 1 were found to be more likely in infants in need for respiratory support or surfactant treatment and susceptibility to infections. We conclude that SP-D concentrations in umbilical cord blood and capillary blood in premature infants are twice as high as in mature infants and depend on several perinatal conditions. High SP-D levels in umbilical cord blood and capillary blood on day 1 were found to be related to increased risk of RDS and infections. R espiratory distress syndrome (RDS) is a main contributor to increased mortality and morbidity among premature infants. RDS is caused by lack of pulmonary surfactant leading to atelectasis and ventilation-perfusion mismatch of the lungs (1). Biochemically, pulmonary surfactant is a mixture of phospholipids and associated proteins which are synthesized, stored, secreted and recycled by type II cells in the airways (2). This mixture forms a monolayer at the air-liquid interface which lowers the surface tension, stabilizes alveoli and terminal airways at low lung volume and prevents alveolar collapse at the end of the expiration. Treatment with synthetic or naturally developed surfactant has been associated with a decline in the mortality of RDS among premature infants (3,4).Four specific surfactant proteins have been identified, called surfactant protein (SP) A-D. SP-B and SP-C have been characterized as hydrophobic polypeptides that enhance the adsorption of lipid to the surface of the alveoli (5), while SP-A and SP-D are hydrophilic and participate in the innate host defense immune system. SP-D binds to macrophages and neutrophils and promotes phagocytosis and killing of bacteria, fungi, and viruses (6). Polymorphism in the amino acid residue 11 of the SPD gene has been found to increase severity of respiratory syncytial virus infection and susceptibility to tuberculosis (7,8).SP-A and SP-B are instrumental in surfactant storage in lamellar bodies and i...

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Section: R Espiratory Distress Syndrome (Rds) Is a Main Contributormentioning

confidence: 99%

Surfactant Protein D Levels in Umbilical Cord Blood and Capillary Blood of Premature Infants. The Influence of Perinatal Factors

et al. 2006

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“…Pulmonary morbidity has been attributed to oxygen toxicity, barotrauma, lung immaturity, and nutritional deficiencies. However, significant variations in pulmonary outcomes of similar infants with comparable exposures to oxygen, mechanical ventilation and nutritional deficiencies suggest that genetic factors also contribute to pulmonary outcomes (28). RDS is the result of complex interactions between several environmental and genetic factors associated with prematurity, gender, race, and maternal diseases (6).…”

Section: Discussionmentioning

confidence: 99%

Surfactant protein B gene polymorphism in preterm babies with respiratory distress syndrome

Lyra

Diniz

Abe‐Sandes³

et al. 2011

Braz J Med Biol Res

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“…Surfactant proteins C and D, in contrast, appear to be involved in the development of chronic affections. Loss of function in alleles expressing the surfactant protein B seems to have greater impact on postnatal affections, potentially generating irreversible acute or chronic effects in susceptible infants [23].…”

Section: Pancreatitis Symptomsmentioning

confidence: 99%

Parenteral Nutrition in the Newborn: Associated Disorders and Nutritional Aspects

Ac¹,

Freitas²

2016

Journal of Nutrition and Health sciences

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Genetic Disorders of Neonatal Respiratory Function

Cited by 82 publications

References 82 publications

Surfactant Protein D Levels in Umbilical Cord Blood and Capillary Blood of Premature Infants. The Influence of Perinatal Factors

Surfactant Protein D Levels in Umbilical Cord Blood and Capillary Blood of Premature Infants. The Influence of Perinatal Factors

Surfactant protein B gene polymorphism in preterm babies with respiratory distress syndrome

Parenteral Nutrition in the Newborn: Associated Disorders and Nutritional Aspects

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