Genetic differentiation and diversity of SARS-CoV-2 Omicron variant in its early outbreak

Weng, Shenghui; Shang, Jingzhe; Cheng, Ye-Xiao; Zhou, Hangyu; Ji, Chengyang; Yang, Rong; Wu, Aiping

doi:10.1016/j.bsheal.2022.04.004

Cited by 17 publications

(15 citation statements)

References 32 publications

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“…The Omicron variant has fifty consensus mutations compared to the standard strain of SARS-CoV-2, including 43 substitutions, six deletions, and one insertion of the nucleotide. At least 27 of these mutations occurred at the S protein, predicted to cause accumulations around the receptor-binding motif [ 6 ]. In addition to the 50 consensus mutations, ten other locations exhibited high-frequency mutations, including seven non-synonymous and three synonymous nucleotide substitutions [ 6 ].…”

Section: Genetic Structure and Mutationsmentioning

confidence: 99%

“…At least 27 of these mutations occurred at the S protein, predicted to cause accumulations around the receptor-binding motif [ 6 ]. In addition to the 50 consensus mutations, ten other locations exhibited high-frequency mutations, including seven non-synonymous and three synonymous nucleotide substitutions [ 6 ]. Fig.…”

Section: Genetic Structure and Mutationsmentioning

confidence: 99%

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Omicron B.1.1.529 subvariant: Brief evidence and future prospects

Farahat¹,

Baklola²,

Umar³

2022

Annals of Medicine &Amp; Surgery

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Section: Genetic Structure and Mutationsmentioning

confidence: 99%

Section: Genetic Structure and Mutationsmentioning

confidence: 99%

Omicron B.1.1.529 subvariant: Brief evidence and future prospects

Farahat¹,

Baklola²,

Umar³

2022

Annals of Medicine &Amp; Surgery

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“…Weng et al . reported that the Omicron variant had 50 consensus mutations, while Alpha, Beta, Gamma, and Delta had 22, 18, 23, and 29 mutations, respectively [ 11 , 12 ]. These mutations have also shown increased infectivity and antibody resistance [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…These are caused by mutations, especially in the spike protein receptor-binding domain (RBD) that enhances viral replication in the upper respiratory tract and in vivo transmission [9]. It was reported that Omicron possesses the most mutation sites and the mutations in its spike protein were approximately three to four times greater than the four previously circulating VOCs [10,11]. Weng et al reported that the Omicron variant had 50 consensus mutations, while Alpha, Beta, Gamma, and Delta had 22, 18, 23, and 29 mutations, respectively [11,12].…”

Section: Introductionmentioning

confidence: 99%

“…It was reported that Omicron possesses the most mutation sites and the mutations in its spike protein were approximately three to four times greater than the four previously circulating VOCs [10,11]. Weng et al reported that the Omicron variant had 50 consensus mutations, while Alpha, Beta, Gamma, and Delta had 22, 18, 23, and 29 mutations, respectively [11,12]. These mutations have also shown increased infectivity and antibody resistance [13].…”

Section: Introductionmentioning

confidence: 99%

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Understanding and combating COVID-19 using the biology and chemistry of SARS-CoV-2

Khan

Goh

Ahmad

et al. 2022

Bioprocess Biosyst Eng

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The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Symptoms of COVID-19 can range from asymptomatic to severe, which could lead to fatality. Like other pathogenic viruses, the infection of SARS-CoV-2 relies on binding its spike glycoprotein to the host receptor angiotensin-converting enzyme 2 (ACE 2). Molecular studies suggested that there is a high affinity between the spike glycoprotein and ACE 2 that might arise due to their hydrophobic interaction. This property is mainly responsible for making this virus highly infectious. Apart from this, the transmissibility of the virus, prolonged viability in certain circumstances, and rapid mutations also contributed to the current pandemic situation. Nanotechnology provides potential alternative solutions to combat COVID-19 with the development of i. nanomaterial-based COVID-19 detection technology, ii. nanomaterial-based disinfectants, iii. nanoparticle-based vaccines, and iv. nanoparticle-based drug delivery. Hence, this review provides diverse insight into understanding COVID-19.

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