Omicron B.1.1.529 subvariant: Brief evidence and future prospects

Farahat, Ramadan Abdelmoez; Baklola, Mohamed; Umar, Tungki Pratama

doi:10.1016/j.amsu.2022.104808

Cited by 14 publications

(20 citation statements)

References 13 publications

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“…Omicron variant (Pango lineage B.1.1.529) has produced different sub-lineages BA.2, BA.3, BA.1, BA.1.1, BA.2.12.1, BA.2.75, BA.2.75.2, BA.4, BA.5 (BA.4/5), BA.4.6, BA.5.1, and one after another these became dominant and predominant strains from time to time by displaying additional immunological escape mechanisms posing significant global health hazards (Ai et al 2022;Aleem et al 2022;Ferré et al 2022;Farahat et al 2022;Graham 2022;Tian et al 2022;Elliot et al 2022;Kurhade et al 2022;Planas et al 2022;Qu et al 2022;Mohapatra et al 2022a;Dhama et al 2023). Omicron variant and subvariants have been implicated to compromise vaccine and infectioninduced immunity and modify virus biology eventually to a higher extent (Evans et al 2022;Cui et al 2022;Qu et al 2022).…”

Section: Omicron Variant Its Emerging Lineages and Subvariantsmentioning

confidence: 99%

“…Explorative research and deeper investigations are required for studying transmissibility, effectiveness of vaccines, immunotherapeutics and antiviral drugs against recently emerging Omicron subvariants and lineages as well as enhance surveillance and monitoring, strengthening genomic facilities for tracking their spread, tight vigilance, and throwing more light on their evolution and mutational events which would aid in formulating appropriate mitigation strategies (Hanai 2022;Qu et al 2022;Uraki et al 2022). These Omicron subvariants could increase the risk of serious illness and hospitalization altogether under threats of cumulative rise in COVID-19 cases again, especially in vulnerable population and under vaccine breakthrough events and reinfection (Farahat et al 2022;Tuekprakhon et al 2022). Of note, circulation of SARS-CoV-2 and its variants among animals including pet and wild animals also need to be checked by strengthening of one health approach and promoting its importance in tackling zoonosis and reverse zoonosis associated with COVID-19, which will also aid in limiting events of mutations and recombination to happen in the virus.…”

Section: Mitigation Strategiesmentioning

confidence: 99%

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SARS-CoV-2 emerging Omicron subvariants with a special focus on BF.7 and XBB.1.5 recently posing fears of rising cases amid ongoing COVID-19 pandemic

et al. 2022

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron versions have been the sole one circulating for quite some time. Subvariants BA.1, BA.2, BA.3, BA.4, and BA.5 of the Omicron emerged over time and through mutation, with BA.1 responsible for the most severe global pandemic between December 2021 and January 2022. Other Omicron subvariants such as BQ.1, BQ.1.1, BA.4.6, BF.7, BA.2.75.2, XBB.1 appeared recently and could cause a new wave of increased cases amid the ongoing COVID-19 pandemic. There is evidence that certain Omicron subvariants have increased transmissibility, extra spike mutations, and ability to overcome protective effects of COVID-19 neutralizing antibodies through immunological evasion. In recent months, the Omicron BF.7 subvariant has been in the news due to its spread in China and a small number of other countries, raising concerns about a possible rebound in COVID-19 cases. More recently, the Omicron XBB.1.5 subvariant has captured international attention due to an increase in cases in the United States. As a highly transmissible sublineage of Omicron BA.5, as well as having a shorter incubation time and the potential to reinfect or infect immune population, BF.7 has stronger infection ability. It appears that the regional immunological landscape is affected by the amount and timing of previous Omicron waves, as well as the COVID-19 vaccination coverage, which in turn determines whether the increased immune escape of BF.7 and XBB.1.5 subvariants is sufficient to drive new infection waves. Expanding our understanding of the transmission and efficacy of vaccines, immunotherapeutics, and antiviral drugs against newly emerging Omicron subvariants and lineages, as well as bolstering genomic facilities for tracking their spread and maintaining a constant vigilance, and shedding more light on their evolution and mutational events, would help in the development of effective mitigation strategies. Importantly, reducing the occurrence of mutations and recombination in the virus can be aided by bolstering One health approach and emphasizing its significance in combating zoonosis and reversal zoonosis linked with COVID-19. This article provides a brief overview on Omicron variant, its recently emerging lineages and subvairants with a special focus on BF.7 and XBB.1.5 as much more infectious and highly transmissible variations that may once again threaten a sharp increase in COVID-19 cases globally amid the currently ongoing pandemic, along with presenting salient mitigation measures.

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Section: Omicron Variant Its Emerging Lineages and Subvariantsmentioning

confidence: 99%

Section: Mitigation Strategiesmentioning

confidence: 99%

SARS-CoV-2 emerging Omicron subvariants with a special focus on BF.7 and XBB.1.5 recently posing fears of rising cases amid ongoing COVID-19 pandemic

et al. 2022

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“…1,2 SARS-CoV-2, within a very few months of the first case, rapidly spread in many countries and consequently led to a devastating pandemic affecting more than 200 countries across the globe. [3][4][5][6] As of January 2023, COVID-19 has resulted in more than 670 million confirmed cases with over 6.8 million deaths. 3 Furthermore, the World Health Organization (WHO) has classified the recent SARS-CoV-2 variants into three categories to monitor and assess the evolution of SARS-CoV-2: variants under monitoring (VUMs), variants of interest (VOIs), and variants of concern (VOCs).…”

Section: Introductionmentioning

confidence: 99%

The Perspectives of Individuals with Comorbidities Towards COVID-19 Booster Vaccine Shots in Twitter: A Social Media Analysis Using Natural Language Processing, Sentiment Analysis and Topic Modeling

Sv¹,

Sundar²,

Vajrobol³

et al. 2023

J. Pure Appl. Microbiol.

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Individuals with comorbidities (i.e., Diabetes Mellitus, hypertension, heart diseases) are more likely to develop a more severe form of coronavirus disease 2019 (COVID-19), thus, they should take necessary precautions to avoid infection with severe acute respiratory syndrome coronavirus–2 (SARS-CoV-2) and its emerging variants and subvariants by getting COVID-19 vaccination and booster doses. In this regard, we used text analytics techniques, specifically Natural Language Processing (NLP), to understand the perception of Twitter users having comorbidities (diabetes, hypertension, and heart diseases) towards the COVID-19 vaccine booster doses. Understanding and identifying Twitter users’ perceptions and perspectives will help the members of medical fraternities, governments, and policymakers to frame and implement a suitable public health policy for promoting the uptake of booster shots by such vulnerable people. A total of 176,540 tweets were identified through the scrapping process to understand the perception of individuals with the mentioned comorbidities regarding the COVID-19 booster dose. From sentiment analysis, it was revealed that 57.6% out of 176,540 tweets expressed negative sentiments about the COVID-19 vaccine booster doses. The reasons for negative expressions have been found using the topic modeling approach (i.e., risk factors, fear of myocardial fibrosis, stroke, or death, and using vaccines as bio-weapons). Of note, enhancing the COVID-19 vaccination drive by administering its booster doses to more and more people is of paramount importance for rendering higher protective immunity under the current threats of recently emerging newer Omicron subvariants which are presently causing a rise in cases in a few countries, such as China and others, and might lead to a feasible new wave of the pandemic with the surge in cases at the global level.

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“…Vaccines are essential for infection control measures, especially during the current Coronavirus Disease 2019 (COVID-19) pandemic. 1 The impact of effective vaccination can be seen either directly or indirectly in reducing new and severe COVID-19 cases, especially following booster vaccination doses. 2 , 3…”

Section: Introductionmentioning

confidence: 99%

The polymorphisms of TNF-α related-gene and antibody production following third dose of COVID-19 vaccination: A pilot study

Liana

Hafy

Fertilita

et al. 2023

Vacunas

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Omicron B.1.1.529 subvariant: Brief evidence and future prospects

Cited by 14 publications

References 13 publications

SARS-CoV-2 emerging Omicron subvariants with a special focus on BF.7 and XBB.1.5 recently posing fears of rising cases amid ongoing COVID-19 pandemic

SARS-CoV-2 emerging Omicron subvariants with a special focus on BF.7 and XBB.1.5 recently posing fears of rising cases amid ongoing COVID-19 pandemic

The Perspectives of Individuals with Comorbidities Towards COVID-19 Booster Vaccine Shots in Twitter: A Social Media Analysis Using Natural Language Processing, Sentiment Analysis and Topic Modeling

The polymorphisms of TNF-α related-gene and antibody production following third dose of COVID-19 vaccination: A pilot study

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