Genetic damage in human cells exposed to non-ionizing radiofrequency fields: A meta-analysis of the data from 88 publications (1990–2011)

Vijayalaxmi, .; Prihoda, Thomas J.

doi:10.1016/j.mrgentox.2012.09.007

Cited by 55 publications

(26 citation statements)

References 106 publications

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“…The γ-H2AX assay was carried out according to the manufacturer's instructions as described in details elsewhere (10). Briefly, lymphocyte-containing interfaces were collected by density gradient centrifugation at 400 g for 30 min.…”

Section: γ-H2ax Foci Analysismentioning

confidence: 99%

“…Nuclear counterstaining was performed with Vectashield medium containing 4′,6-diamidino-2-phenylindole (DAPI). The AKLIDES platform was used for automated image acquisition, analysis, evaluation and characterization of γ-H2AX foci as previously described (10,12,17).…”

Section: γ-H2ax Foci Analysismentioning

confidence: 99%

“…Consistent with different groups of researches, RFs were proven to induce DNA single-and double-strand breaks (DSB), the latter being thought to be the most severe form of DNA damage since they may lead to severe losses of large fragments of DNA. However, the negative effects could only be observed in studies with small sample numbers, thus failing to provide solid genotoxicity-based mechanistic evidence (10).…”

Section: Introductionmentioning

confidence: 99%

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Mobile phone radiofrequency exposure has no effect on DNA double strand breaks (DSB) in human lymphocytes

et al. 2017

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Background: The use of mobile phones has been associated with an increased risk of developing certain type of cancer, especially in long term users. Therefore, this study was aimed to investigate the potential genotoxic effect of mobile phone radiofrequency exposure on human peripheral blood mononuclear cells in vitro. Methods:The study population consisted in 14 healthy volunteers. After collection of two whole blood samples, the former was placed in a plastic rack, 1 cm from the chassis of a commercial mobile phone (900 MHz carrier frequency), which was activated by a 30-min call. The second blood sample was instead maintained far from mobile phones or other RF sources. The influence of mobile phone RF on DNA integrity was assessed by analyzing γ-H2AX foci in lymphocytes using immunofluorescence staining kit on AKLIDES.Results: No measure of γ-H2AX foci was significantly influenced by mobile phone RF exposure, nor mobile phone exposure was associated with significant risk of genetic damages in vitro (odds ratio comprised between 0.27 and 1.00). Conclusions:The results of this experimental study demonstrate that exposure of human lymphocytes to a conventional 900 MHz RF emitted by a commercial mobile phone for 30 min does not significantly impact DNA integrity.

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Section: γ-H2ax Foci Analysismentioning

confidence: 99%

Section: γ-H2ax Foci Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mobile phone radiofrequency exposure has no effect on DNA double strand breaks (DSB) in human lymphocytes

et al. 2017

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“…Investigations are also being conducted to examine the impact of simultaneous/sequential exposure of RF with other physical/chemical genotoxic agents. Several reviews have already been published, the conclusions being that RF exposure alone has no genotoxic potential while the combined exposure effects need further investigation [see recent reviews in 15, 16]. …”

Section: Introductionmentioning

confidence: 99%

Adaptive response in human blood lymphocytes exposed to non-ionizing radiofrequency fields: resistance to ionizing radiation-induced damage

Sannino

Zeni

Romeo

et al. 2013

Journal of Radiation Research

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The aim of this preliminary investigation was to assess whether human peripheral blood lymphocytes which have been pre-exposed to non-ionizing radiofrequency fields exhibit an adaptive response (AR) by resisting the induction of genetic damage from subsequent exposure to ionizing radiation. Peripheral blood lymphocytes from four healthy donors were stimulated with phytohemagglutinin for 24 h and then exposed for 20 h to 1950 MHz radiofrequency fields (RF, adaptive dose, AD) at an average specific absorption rate of 0.3 W/kg. At 48 h, the cells were subjected to a challenge dose (CD) of 1.0 or 1.5 Gy X-irradiation (XR, challenge dose, CD). After a 72 h total culture period, cells were collected to examine the incidence of micronuclei (MN). There was a significant decrease in the number of MN in lymphocytes exposed to RF + XR (AD + CD) as compared with those subjected to XR alone (CD). These observations thus suggested a RF-induced AR and induction of resistance to subsequent damage from XR. There was variability between the donors in RF-induced AR. The data reported in our earlier investigations also indicated a similar induction of AR in human blood lymphocytes that had been pre-exposed to RF (AD) and subsequently treated with a chemical mutagen, mitomycin C (CD). Since XR and mitomycin-C induce different kinds of lesions in cellular DNA, further studies are required to understand the mechanism(s) involved in the RF-induced adaptive response.

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“…The mechanism of the possible carcinogenic effects of electromagnetic fields is unclear. Analysis of studies devoted to this problem allows us to conclude that exposure to low-frequency electromagnetic field is not the cause of increased risk of brain tumors (Vijayalaxmi and Prihoda, 2012).…”

Section: Discussionmentioning

confidence: 99%

Malignant Tumours of the Central Nervous System in Kazakhstan - Incidence Trends from 2004-2011

Igissinov¹,

Akshulakov²,

Igissinov³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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In the article were observed the epidemiological aspects of malignant tumors of the central nervous system (MT CNS) in Kazakhstan in a retrospective study for the years 2004-2011. The material of the study was consolidated accounting data of oncology centers on patients with MT CNS (C70-72) with first time established diagnosis. Calculated were crude, age, standardized (world standard), aligned and predicted incidence of MT CNS among both male and female populations. It was found that over the studied period, there were 4,604 cases of MT CNS. The average annual crude incidence rate of MT CNS in total population was 3.7±0.1 0 / 0000 . Trends in aligned incidence rates in the whole country had a tendency to increase (T=+0.9%). Defined levels of morbidity MT CNS in the whole population in different regions of Kazakhstan: low up to 2.87 0 / 0000 , the average from 2.87 to 4.45 0 / 0000 and high from 4.45 0 / 0000 and above on the basis of which was given the space-time estimate. Age and sex differences in MT CNS incidence were also clearly established

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Genetic damage in human cells exposed to non-ionizing radiofrequency fields: A meta-analysis of the data from 88 publications (1990–2011)

Cited by 55 publications

References 106 publications

Mobile phone radiofrequency exposure has no effect on DNA double strand breaks (DSB) in human lymphocytes

Mobile phone radiofrequency exposure has no effect on DNA double strand breaks (DSB) in human lymphocytes

Adaptive response in human blood lymphocytes exposed to non-ionizing radiofrequency fields: resistance to ionizing radiation-induced damage

Malignant Tumours of the Central Nervous System in Kazakhstan - Incidence Trends from 2004-2011

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