Genetic control of natural antibody repertoires: I. IgH, MHC and TCRβ loci

Vasconcellos, Ricardo José de Holanda; Nóbrega, Alberto; Haury, Matthias; Viale, Anne-Claire; Coutinho, António

doi:10.1002/(sici)1521-4141(199803)28:03<1104::aid-immu1104>3.3.co;2-f

Cited by 10 publications

(15 citation statements)

References 32 publications

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“…They are the product of natural selection, exhibiting a genetically determined and stable repertoire that is largely independent of external antigenic stimuli (35)(36)(37). NAbs have been defined in various ways, for example, as the IgM present in normal plasma (38), but more stringently, as germline-encoded Abs that arise without any exogenous immune exposure or bacterial colonization of the gut (39).…”

Section: Discussionmentioning

confidence: 99%

Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans

Chou¹,

Fogelstrand²,

Hartvigsen³

et al. 2009

J. Clin. Invest.

413

452

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Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of oxidized lipoproteins and apoptotic cells. Adaptive immune responses to various oxidation-specific epitopes play an important role in atherogenesis. However, accumulating evidence suggests that these epitopes are also recognized by innate receptors, such as scavenger receptors on macrophages, and plasma proteins, such as C-reactive protein (CRP). Here, we provide multiple lines of evidence that oxidation-specific epitopes constitute a dominant, previously unrecognized target of natural Abs (NAbs) in both mice and humans. Using reconstituted mice expressing solely IgM NAbs, we have shown that approximately 30% of all NAbs bound to model oxidation-specific epitopes, as well as to atherosclerotic lesions and apoptotic cells. Because oxidative processes are ubiquitous, we hypothesized that these epitopes exert selective pressure to expand NAbs, which in turn play an important role in mediating homeostatic functions consequent to inflammation and cell death, as demonstrated by their ability to facilitate apoptotic cell clearance. These findings provide novel insights into the functions of NAbs in mediating host homeostasis and into their roles in health and diseases, such as chronic inflammatory diseases and atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans

Chou¹,

Fogelstrand²,

Hartvigsen³

et al. 2009

J. Clin. Invest.

413

452

View full text Add to dashboard Cite

show abstract

“…It should be noted that previous studies also documented the influence of immune-related genes (e.g. MHC) on repertoire specificity of circulating Abs (29,30).…”

Section: Discussionmentioning

confidence: 99%

A Study on the Glycan Specificity of Natural Antibody Repertoires in Rodents

Dai

Zhang

et al. 2009

Cell Mol Immunol

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Inbred strains of mice and rats are widely used in preclinical investigations evaluating the effectiveness of glycanbased biomecines, however, the glycan specificity repertoires of serum Abs in rodents have not been fully characterized. In the present study, serum antibodies in naïve mice and rats of different inbred strains were analyzed for specificity against 4 representative carbohydrate structures including PGA (1,4-linked -Dgalactopyranosyluronic acids), -glucan, mannan and -glucan (dextran).

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“…Mice are able to establish their patterns of IgM formation early in ontogenesis, and they keep them stable even when created in "antigen-free" conditions 23 ; distinct isogenic strains have distinct reactivity profiles and these differences depend on the gene complexes that are important in the determination of immune reactivity 37 . Horses are able to keep the profiles of IgM reactivity and a large part of IgG profiles stable even when undergoing brutal regimens of hyperimmunization used in the production of therapeutic antiserum, such as the anti-tetanus serum 38 .…”

Section: Reactivity Patterns In Normal Immunoglobulinsmentioning

confidence: 99%