Genetic control of epithelial cell polarity: Lessons fromDrosophila

Müller, H.‐Arno J.

doi:10.1002/(sici)1097-0177(200005)218:1<52::aid-dvdy5>3.0.co;2-l

Cited by 97 publications

(12 citation statements)

References 116 publications

(112 reference statements)

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“…Likewise, expression of a dominant negative Rab5 in the follicular epithelium or expression of rab11-RNAi results in mislocalized SJ proteins in stage 11/12 egg chambers. This progression of SJ biogenesis is consistent with ultrastructural analysis showing electron dense septa in the follicular epithelium of egg chambers from stage 10B, but not before ( [6]; but note nascent electron dense material can be observed as early as stage 6: [56]).…”

Section: Biogenesis Of the Sjsupporting

confidence: 88%

“…The follicular epithelium has apical-basal polarity with junctional organization on the lateral membranes. Mahowald [6] demonstrated the presence of mature SJs beginning in stage 10B egg chambers using electron microscopy, although there is evidence of some nascent SJ extracellular material as early as stage 6 [56]. Not surprisingly, many of the core SJ proteins have been identified in the follicular epithelium, consistent with the presence of SJs in this tissue [23,[90][91][92][93].…”

Section: Morphogenetic Events During Oogenesismentioning

confidence: 85%

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Expanding the Junction: New Insights into Non-Occluding Roles for Septate Junction Proteins during Development

Rice

Alhadyian

et al. 2021

JDB

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The septate junction (SJ) provides an occluding function for epithelial tissues in invertebrate organisms. This ability to seal the paracellular route between cells allows internal tissues to create unique compartments for organ function and endows the epidermis with a barrier function to restrict the passage of pathogens. Over the past twenty-five years, numerous investigators have identified more than 30 proteins that are required for the formation or maintenance of the SJs in Drosophila melanogaster, and have determined many of the steps involved in the biogenesis of the junction. Along the way, it has become clear that SJ proteins are also required for a number of developmental events that occur throughout the life of the organism. Many of these developmental events occur prior to the formation of the occluding junction, suggesting that SJ proteins possess non-occluding functions. In this review, we will describe the composition of SJs, taking note of which proteins are core components of the junction versus resident or accessory proteins, and the steps involved in the biogenesis of the junction. We will then elaborate on the functions that core SJ proteins likely play outside of their role in forming the occluding junction and describe studies that provide some cell biological perspectives that are beginning to provide mechanistic understanding of how these proteins function in developmental contexts.

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Section: Biogenesis Of the Sjsupporting

confidence: 88%

Section: Morphogenetic Events During Oogenesismentioning

confidence: 85%

Expanding the Junction: New Insights into Non-Occluding Roles for Septate Junction Proteins during Development

Rice

Alhadyian

et al. 2021

JDB

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“…To this end, we recombined the Fas2 exon trap GFP insertion with the Tao eta mutation. To mark cell clones independently of GFP, we generated a P(neoFRT)19A chromosome with a follicle cell–specific enhancer trap, enabling us to detect follicle cell nuclei that are wild type for Tao with β-Galactosidase (Müller, 2000). Using these chromosomes, we generated cell clones colabeled for Fas2-GFP and Rab5 and quantified confocal pictures by counting the number of Rab5 vesicles, vesicular Fas2 structures, and their colocalization.…”

Section: Resultsmentioning

confidence: 99%

“…A potential role of actin-Myosin-based contractility in preventing cell stretching can be deduced from data in the Drosophila follicular epithelium, where cells lacking Myosin function undergo a transition from a cuboidal to squamous cell shape (Wang and Riechmann, 2007). The same phenotype was observed when the function of adherens junctions is disturbed (Müller, 2000;Tanentzapf et al, 2000). The finding that compromised cell adhesion results in cell flattening suggests that squamous cell morphogenesis can be induced by reducing adhesion between cells.…”

Section: Introductionmentioning

confidence: 99%

Tao controls epithelial morphogenesis by promoting Fasciclin 2 endocytosis

Gomez

Wang

Riechmann

2012

Journal of Cell Biology

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“…Gap junctions have been also observed in egg chambers from stages 2 to 10 [ 27 , 28 ]. In addition, incipient septate junctions have been described from stage 6 egg chambers [ 29 , 30 ]. However, gap and septate junctions, do not seem to be relevant for germ cell maintenance and dynamics in regions 2a–2b of the germarium.…”

Section: Discussionmentioning

confidence: 99%

Cell-to-Cell Interactions during Early Drosophila Oogenesis: An Ultrastructural Analysis

Riparbelli

Persico

Callaini

2022

Cells

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Drosophila oogenesis requires the subsequent growth of distinct egg chambers each containing a group of sixteen germline cells surrounded by a simple epithelium of follicle cells. The oocyte occupies a posterior position within the germ cells, thus giving a distinct asymmetry to the egg chamber. Although this disposition is critical for the formation of the anterior–posterior axis of the embryo, the interplay between somatic and germ cells during the early stages of oogenesis remains an open question. We uncover by stage 2, when the egg chambers leaved the germarium, some unique spatial interactions between the posterior follicle cells and the oocyte. These interactions are restricted to the surface of the oocyte over the centriole cluster that formed during early oogenesis. Moreover, the posterior follicle cells in front of the oocyte display a convoluted apical membrane with extensive contacts, whereas the other follicle cells have a flat apical surface without obvious surface protrusions. In addition, the germ cells located at the posterior end of the egg chamber have very elongated protrusions that come into contact with each other or with facing follicle cells. These observations point to distinct polarization events during early oogenesis supporting previous molecular data of an inherent asymmetry between the anterior and the posterior regions of the egg chambers.

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Genetic control of epithelial cell polarity: Lessons fromDrosophila

Cited by 97 publications

References 116 publications

Expanding the Junction: New Insights into Non-Occluding Roles for Septate Junction Proteins during Development

Expanding the Junction: New Insights into Non-Occluding Roles for Septate Junction Proteins during Development

Tao controls epithelial morphogenesis by promoting Fasciclin 2 endocytosis

Cell-to-Cell Interactions during Early Drosophila Oogenesis: An Ultrastructural Analysis

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