Genetic Control of Antibody Responses to PHA in Inbred Rats

Koch, Claus

doi:10.1111/j.1365-3083.1976.tb00256.x

Cited by 3 publications

(1 citation statement)

References 6 publications

(5 reference statements)

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“…Unlike F344 rats, the most commonly used rat model for aging, in BN rats there is low morbidity from pituitary adenomas or glomerulonephrosis with increasing age (Lipman et al, 1996, 1999; Nadon, 2004). BN and F344 rats also differ in their behavior (Rex et al, 1996; Ramos et al, 1997), learning and memory (van der Staay et al, 1996), immune function (Sado et al, 1986; Koch 1976; Stankus and Leslie 1976; Festing, 1998; Lipman, 1996, 1999), and stress responses (Segar et al, 2008; Duclos et al, 2005; Sarrieau et al, 1998; Gómez et al, 1998), which may affect NA nerve integrity in the spleen with advancing age.…”

Section: Introductionmentioning

confidence: 99%

Sympathetic innervation of the spleen in male Brown Norway rats: A longitudinal aging study

Perez¹,

Silva²,

Millar³

et al. 2009

Brain Research

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Aging leads to reduced cellular immunity with consequent increased rates of infectious disease, cancer and autoimmunity in the elderly. The sympathetic nervous system (SNS) modulates innate and adaptive immunity via innervation of lymphoid organs. In aged Fischer 344 (F344) rats, noradrenergic (NA) nerve density in secondary lymphoid organs declines, which may contribute to immunosenescence with aging. These studies suggest there is SNS involvement in age-induced immune dysregulation. Objectives The purpose of this study was to longitudinally characterize age-related change in sympathetic innervation of the spleen and sympathetic activity/tone in male Brown Norway (BN) rats, which live longer and have a strikingly different immune profile than the F344 rat, the traditional animal model for aging research. Methods Splenic sympathetic neurotransmission was evaluated between 8 and 32 months of age by (1) NA nerve fiber density; (2) splenic norepinephrine (NE) concentration; and (3) circulating catecholamines levels after decapitation. Results We report a decline in noradrenergic nerve density in splenic white pulp (45%) at 18 months of age compared with 8 month-old (M) rats, which is followed by a much slower rate of decline between 18 and 32 months. Lower splenic NE concentrations were consistent with morphometric findings. Circulating catecholamines levels generally dropped with increasing age. Conclusion These findings suggest there is a sympathetic-to-immune system dysregulation beginning at middle age. Given the unique T-helper-2 bias in Brown Norway rats, altered sympathetic-immune communication may be important for understanding the age-related rise in asthma and autoimmunity.

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Section: Introductionmentioning

confidence: 99%

Sympathetic innervation of the spleen in male Brown Norway rats: A longitudinal aging study

Perez¹,

Silva²,

Millar³

et al. 2009

Brain Research

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Accessory cell function of thoracic duct nonlymphoid cells, dendritic cells, and splenic adherent cells in the Brown-Norway rat

Nagelkerken

Henfling

Vriesman

1985

Cellular Immunology

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Genetic Control of the In Vitro Responses of Rat Blood Lymphocytes

Koch

1976

Scand J Immunol

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Blood lymphocytes from the inbred rat strains AS and BN differ in the magnitude both of their in vitro proliferative response to different mitogens and of their in vivo antibody response to the mitogenic fraction of phytohemagglutinin (PHA). We have examined the segregation of in vitro responsiveness to PHA in (AS × BN)F1× BN backcross rats and have tried to correlate it with other characters that vary in backcross rats. In vitro responsiveness regulated by one or a few loci, is linked to the in vitro responsiveness to B lymphocyte mitogens and the in vivo antibody response to the mitogenic fraction of PHA, but is not linked to the major histocompatibility locus (Ag‐B) nor to the frequency of short‐lived, small Ig‐negative lymphocytes in blood. Lymphocytes from high‐responder rats have a shorter lag period before the onset of DNA synthesis in vitro than low‐responder rats, and possibly also a higher number of in vitro responding cells. To explain our findings, that the same gene og genes regulate in vitro responsiveness to different mitogens and in vivo antibody response to the mitogenic fraction of PHA, we suggest that the gene or genes act in an immunologically unspecific manner on regulation of lymphocyte proliferation in vitro as well as in vivo.

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Genetic Control of Antibody Responses to PHA in Inbred Rats

Cited by 3 publications

References 6 publications

Sympathetic innervation of the spleen in male Brown Norway rats: A longitudinal aging study

Sympathetic innervation of the spleen in male Brown Norway rats: A longitudinal aging study

Accessory cell function of thoracic duct nonlymphoid cells, dendritic cells, and splenic adherent cells in the Brown-Norway rat

Genetic Control of the In Vitro Responses of Rat Blood Lymphocytes

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