Accessory cell function of thoracic duct nonlymphoid cells, dendritic cells, and splenic adherent cells in the Brown-Norway rat

Analysis of Monocyte Chemotactic Protein-1 Production in Different Major Histocompatability Complex-Restricted Antigen Presentation Systems

“…Thus, it appears that Con A-induced T cell proliferation proceeds via a route different from that of MHC II-antigen binding and probably without the need for close cellto-cell contact. In this system, mainly the T cell is activated, and not the antigen-presenting cell (19,20). In contrast to aspecific receptor cross-linking on the lymphocyte by Con A, it appears that highly specific Engagement of the MHC II-antigen complex by its specific TCR and probably the engagement of costimulatory adhesion molecules delivers activation signals into both the T cells and the APCs (17).…”

The effects ofin vivocyclosporin A administration on rat thymic dendritic cells

“…Although this marker is not restricted to this cell type, the labelling correlates with DC, forming a diffuse network in the thymic medulla [14]. Furthermore, the isolated DC are ver\ efficient accessory cells and induce strong T cell proliferative responses in an allogeneic MLR comparable to DC isolated from the thoracic duct lymph [25]. Upon in vivo CsA administration our results show a concentration-dependent decrease in DC number, bul it never results in a complete disappearance of DC.…”

Predictors of Mortality in Patients with Isomerism

“…Patients with pulmonary atresia and obstructed anomalous pulmonary venous connections are known to be at particularly high risk [24]. The increased risk of bacteremia is likely due to splenic dysfunction and alterations in B-cell populations, further compounded by the presence of invasive monitoring lines and endotracheal tubes [25,26].…”