Abstract:SUMMARYCyelosporin A (CsA) induces a graft-ver^wi-host-like disease (GVHD) in lethally irradiated Lewis rats reconstituted with syngeneie bone marrow. The role of the thymus in the generation of disease has been unequivocally established. It has been suggested that the CsA-induced disappearance of thymic dendritic eells (DC) is responsible for the generation of the autoaggressive celis. In this study we quantify the loss of DC upon in vivo CsA administration in normal and bone marrowreconstituted rats using an… Show more
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