Genetic characterization of feline parvovirus sequences from various carnivores

Steinel, Ariane; Munson, Linda; Vuuren, Moritz Van; Truyen, Uwe

doi:10.1099/0022-1317-81-2-345

Cited by 133 publications

(171 citation statements)

References 17 publications

(29 reference statements)

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“…The occurrence of catastrophic feline infectious peritonitis (FIP) epidemics in captive cheetahs was cited as support for this hypothesis (Evermann et al, 1983). The propensity for cheetahs to maintain persistent viral infections and develop atypical immune responses to common pathogens (Evermann et al, 1988;Junge et al, 1991;Eaton et al, 1993;Steinel et al, 2000;Munson et al, 2003) may also have a genetic basis, although modulation of the immune response by chronic stress has also been proposed . In light of these suspected inherent vulnerabilities to viral agents, we were surprised to find that morbidity and mortality in North American (NA) cheetahs were principally due to chronic degenerative diseases, such as veno-occlusive disease, glomerulosclerosis, and amyloidosis, rather than infectious disease (Munson, 1993;Papendick et al, 1997;Bolton and Munson, 1999).…”

Section: Introductionmentioning

confidence: 99%

Extrinsic Factors Significantly Affect Patterns of Disease in Free-Ranging and Captive Cheetah (Acinonyx Jubatus) Populations

Munson

Terio

Worley

et al. 2005

Journal of Wildlife Diseases

111

112

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The cheetah (Acinonyx jubatus) has been considered a paradigm for disease vulnerability due to loss of genetic diversity. This species monomorphism has been suspected to be the basis for their general poor health and dwindling populations in captivity. North American and South African captive populations have high prevalences of hepatic veno-occlusive disease, glomerulosclerosis, gastritis, and systemic amyloidosis, diseases that are rare in other species. Unusually severe inflammatory reactions to common infectious agents have also been documented in captive cheetahs. The current study compared disease prevalences in free-ranging Namibian cheetahs with those in two captive populations of similar ages. The occurrence of diseases in the free-ranging population was determined from 49 necropsies and 27 gastric biopsies obtained between 1986 and 2003 and compared with prevalences in 147 North American and 80 South African captive cheetahs. Except for two cheetahs, the free-ranging population was in robust health with only mild lesions present, in contrast with significantly higher prevalences in the captive populations. Despite widespread heavy Helicobacter colonization in wild cheetahs, only 3% of the free-ranging population had moderate to severe gastritis, in contrast with 64% of captive cheetahs. No severe inflammatory reactions to viral infections were detected in the free-ranging animals. Because free-ranging Namibian cheetahs are as genetically impoverished as captive cheetahs, these findings caution against attributing loss of fitness solely to genetic factors and attest to the fundamental importance of extrinsic factors in wildlife health.

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Section: Introductionmentioning

confidence: 99%

Extrinsic Factors Significantly Affect Patterns of Disease in Free-Ranging and Captive Cheetah (Acinonyx Jubatus) Populations

Munson

Terio

Worley

et al. 2005

Journal of Wildlife Diseases

111

112

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“…CPV-2a and CPV-2b DNA sequences were recovered from six of nine cheetahs, as well as from one Siberian tiger, all showing clinical symptoms of parvovirus disease [88]. The very high prevalence of CPV-2a/ 2b infections in large cats compared to domestic cats may suggest a higher susceptibility of the species for these virus types [88]. Since vaccination of domestic cats and dogs is very effective in preventing disease, parvovirus vaccination of all domestic and non-domestic carnivores at risk of infection is highly recommended.…”

Section: Canine Parvovirus Variants In Wild Animalsmentioning

confidence: 99%

“…Canine parvovirus infections were reported in farmed raccoon dogs and confirmed to be CPV-2 by DNA sequence analysis of the VP2 gene [93]. CPV-2a and CPV-2b DNA sequences were recovered from six of nine cheetahs, as well as from one Siberian tiger, all showing clinical symptoms of parvovirus disease [88]. The very high prevalence of CPV-2a/ 2b infections in large cats compared to domestic cats may suggest a higher susceptibility of the species for these virus types [88].…”

Section: Canine Parvovirus Variants In Wild Animalsmentioning

confidence: 99%

Canine Parvovirus: Current Perspective

2010

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“…Although antibodies against some viruses provide protection against infection, FIV, FHV1, and rarely FCV and FPV infections (Steinel et al, 2000;Lenghaus et al, 2001) can persist in seropositive hosts, and virus can be shed from asymptomatic carriers. Therefore, prior to any translocation, lions from both origin and destination sites should be screened for evidence of these viruses to prevent introduction into naÏve populations.…”

mentioning

confidence: 99%

A Serosurvey of Viral Infections in Lions (Panthera leo), from Queen Elizabeth National Park, Uganda

Driciru

Siefert

Prager

et al. 2006

Journal of Wildlife Diseases

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ABSTRACT:Serum samples from 14 lions (Panthera leo) from Queen Elizabeth National Park, Uganda, were collected during 1998 and 1999 to determine infectious disease exposure in this threatened population. Sera were analyzed for antibodies against feline immunodeficiency virus (FIV), feline calicivirus (FCV), feline herpesvirus 1 (feline rhinotracheitis: FHV1), feline/canine parvovirus (FPV/CPV), feline infectious peritonitis virus (feline coronavirus: FIPV), and canine distemper virus (CDV) or for the presence of feline leukemia virus (FeLV) antigens. Ten lions (71%) had antibodies against FIV, 11 (79%) had antibodies against CDV, 11 (79%) had antibodies against FCV, nine (64%) had antibodies against FHV1, and five (36%) had antibodies against FPV. Two of the 11 CDV-seropositive lions were subadults, indicating recent exposure of this population to CDV or a CDV-like virus. No lions had evidence of exposure to FeLV or FIPV. These results indicate that this endangered population has extensive exposure to common feline and canine viruses.

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Genetic characterization of feline parvovirus sequences from various carnivores

Cited by 133 publications

References 17 publications

Extrinsic Factors Significantly Affect Patterns of Disease in Free-Ranging and Captive Cheetah (Acinonyx Jubatus) Populations

Extrinsic Factors Significantly Affect Patterns of Disease in Free-Ranging and Captive Cheetah (Acinonyx Jubatus) Populations

Canine Parvovirus: Current Perspective

A Serosurvey of Viral Infections in Lions (Panthera leo), from Queen Elizabeth National Park, Uganda

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