Genetic characterization of a rare H12N3 avian influenza virus isolated from a green-winged teal in Japan

Bui, Vuong Nghia; Ogawa, Hideoki; Hussein, Islam T. M.; Hill, Nichola J.; Trinh, Dai Quang; AboElkhair, Mohammed; Sultan, Serageldeen; Ma, Eric; Saito, Keisuke; Watanabe, Yukiko; Runstadler, Jonathan A.; Imai, Kunitoshi

doi:10.1007/s11262-014-1162-9

Cited by 7 publications

(5 citation statements)

References 31 publications

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“…For example, investigations of human infections by the H7N9 AIV revealed that the H11N9 AIV was the donor of its NA gene [ 14 ]. The H12 subtype of AIV was first found in Canada in 1983 in Ring-Billed Gulls [ 15 ] and was detected in Green-Winged Teals in Japan in 2015 [ 16 ]. As little research has been conducted on H12 AIVs [ 7 , 17 ], their ecology and phylogeny remain largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Avian Influenza Virus H10–H12 Subtypes Isolated from Wild Birds in Shanghai, China from 2016 to 2019

Tang

Ming

et al. 2020

Viruses

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H10, H11 and H12 (H10–H12) subtypes of the avian influenza virus (AIV) are associated with waterfowl. Although these subtypes of AIV are infrequently detected in nature, they can undergo reassortment with other AIV subtypes. Few H10–H12 subtypes of AIV have been isolated from wild birds in China. In this study, 12 AIV isolates of H10–H12 subtypes were identified via routine surveillance of wild birds in Shanghai, China from 2016 to 2019, including two H10, three H11 and seven H12 isolates. Sequence and phylogenetic analyses revealed that the genomic segments of the 12 isolates are highly diverse. These 12 isolates are closely related to those in the Eurasian lineage and share a high degree of sequence identity with those from wild birds and domestic ducks in countries in the East Asian–Australasian Flyway, including Japan, Korea, Bangladesh, Vietnam and China. However, parts of the genomic segments of two H12N2 isolates (NH112319-H12N2 and NH101807-H12N2) belong to the North American lineage, suggesting intercontinental reassortment among H12 AIVs in Eurasia and North American. To better understand the ecological and phylodynamic features of H10–H12 subtypes in wild birds, a large-scale surveillance of AIVs in wild birds is warranted.

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Section: Introductionmentioning

confidence: 99%

Characterization of Avian Influenza Virus H10–H12 Subtypes Isolated from Wild Birds in Shanghai, China from 2016 to 2019

Tang

Ming

et al. 2020

Viruses

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“…The HA gene of the H12 viruses seems to have a combination bias with the N5 gene because 58.68% of the identified H12 strains are H12N5 viruses. Although H12N5 viruses have been detected on five continents, the North American viruses make up the majority of the identified strains [43][44][45]. Several determinants, including the surveillance network, bird species and number, and established migratory flyway, may collectively contribute to the detection of H12 viruses in birds [46].…”

Section: Discussionmentioning

confidence: 99%

Ecological and Genetic Landscapes of Global H12 Avian Influenza Viruses and Biological Characteristics of an H12N5 Virus Isolated from Wild Ducks in Eastern China

Wang,

Guo,

Zhang

et al. 2024

Transboundary and Emerging Diseases

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Wild migratory birds are considered the central reservoirs of avian influenza viruses. H12 viruses are one of the 16 hemagglutinin (HA) subtypes of avian influenza viruses and are rarely reported because they are infrequently detected in birds. Consequently, the ecological and genetic profiles of H12 viruses and their adaptation in domestic birds and mammals remain unclear. Here, we found that H12N5 viruses were predominant in the nine identified H12NX subtypes, with the HA (H12) and neuraminidase (NA) (N5) genes showing combination bias in the categorized analysis of subtype combinations (H12 and N1–N9; H1–H12, H14, H15, and N5). These identified H12N5 viruses were primarily detected in birds of Anatidae and Scolopacidae in North America, excluding their possible characterization as chicken or mammalian viruses. The H12N5 viruses were divided into the North American lineage and Eurasian lineage according to their genetic differences, including the HA and NA surface genes and internal genes, although reassortment was observed between the two lineages. We isolated an Eurasian-lineage H12N5 virus from wild ducks in Eastern China, which was one of the 12 identified H12 viruses in China. Infectivity studies indicated that the H12N5 virus is poorly adapted to domestic ducks and chickens, although viral shedding could be detected in both inoculated and contact birds. Additionally, the naturally isolated H12N5 virus did not achieve good replication in mice. These results indicate that the rare subtype of H12 viruses was mainly pooled in wild migratory birds and has an established phylogeography, with low risks of spillover into domestic birds and mammals.

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“…The Eurasian teal can cover long distances (an average of 160 km over 30 days) and is one of the main natural reservoirs of AI virus (53), and therefore may have a high potential for spreading this virus (54). The following subtypes of AI have been isolated from Eurasian teals in different countries: H12N3, H8N4, H15N4, N5N1 (52,(55)(56)(57)(58)(59)(60).…”

Section: Discussionmentioning

confidence: 99%

A highly pathogenic avian influenza virus H5N1 clade 2.3.4.4 detected in Samara Oblast, Russian Federation

Glazunova,

Krasnova,

Bespalova

et al. 2024

Front. Vet. Sci.

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Avian influenza (AI) is a global problem impacting birds and mammals, causing economic losses in commercial poultry farms and backyard settings. In 2022, over 8,500 AI cases were reported worldwide, with the H5 subtype being responsible for many outbreaks in wild and domestic birds. In the territory of the Russian Federation, outbreaks of AI have been massively reported since 2020, both among domestic bird species and wild bird species. Wild migratory birds often serve as natural reservoirs for AI viruses, and interactions between bird species can lead to the emergence of new, highly pathogenic variants through genetic recombination between strains. In order to combat the widespread outbreaks of the disease and potential risks of further spread in 2021, monitoring studies were conducted in the Samara Oblast, the southeastern region of European Russian Federation. These studies aimed to diagnose and characterize circulating AI virus variants among wild migratory birds during waterfowl hunting in areas of mass nesting. Among the 98 shot birds, a highly pathogenic A/H5N1 AI virus was detected in a Eurasian Teal from the Bolshechernigovsky district. It was classified into clade 2.3.4.4 based on the cleavage site structure of HA. Phylogenetic analysis showed a high relatedness of the identified strain in the Samara Oblast with field isolates from Russia, Nigeria, Bangladesh, and Benin. The article emphasizes the importance of monitoring AI virus spread in both wild and poultry, highlighting the need for timely information exchange to assess risks. Further comprehensive studies are necessary to understand virus dissemination pathways.

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Genetic characterization of a rare H12N3 avian influenza virus isolated from a green-winged teal in Japan

Abstract: This study reports on the genetic

Cited by 7 publications

References 31 publications

Characterization of Avian Influenza Virus H10–H12 Subtypes Isolated from Wild Birds in Shanghai, China from 2016 to 2019

Characterization of Avian Influenza Virus H10–H12 Subtypes Isolated from Wild Birds in Shanghai, China from 2016 to 2019

Ecological and Genetic Landscapes of Global H12 Avian Influenza Viruses and Biological Characteristics of an H12N5 Virus Isolated from Wild Ducks in Eastern China

A highly pathogenic avian influenza virus H5N1 clade 2.3.4.4 detected in Samara Oblast, Russian Federation

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