Genetic characterization of a rare bovine-like human VP4 mono-reassortant G6P[8] rotavirus strain detected from an infant in Bangladesh

Molecular Epidemiology of Rotavirus in Cats in the United Kingdom

“…G6 is a common genotype in cattle/buffalo (67)(68)(69)(70), sheep (71)(72)(73), and goats (74,75) and has been identified sporadically or at a low prevalence in rabbits (76) and pigs (77,78). It is uncommon in people, and although a zoonotic origin is postulated (64,(79)(80)(81)(82)(83), it has not yet been convincingly proven whether such zoonotic strains spread among people. More recently, with the advent of advanced genome sequencing techniques and a more robust classification system (84), the possibility of G6 feline origin at some historical point has been proposed (16).…”

Zoonotic transmission of rotavirus: surveillance and control

“…Global surveillance efforts provided solid evidence that reassortment between human and animal RVAs is crucial for stable introduction of animal rotavirus genes and efficient human-tohuman transmission of such human-animal reassortant rotaviruses. Examples include unusual reassortants between common human strains and animal viruses, such as a recent bovinehuman reassortant G6P[8] strain detected in Bangladesh [76]. However, the most prominent examples are G9P[8] and G12P [8] strains, which became globally common during the late 1990s and early 2000s [55,58,77].…”

Whole genomic analysis of human and bovine G8P[1] rotavirus strains isolated in Nigeria provides evidence for direct bovine-to-human interspecies transmission

“…Strains HMG035 and NGRBg8 were found to share the same non-G/P genotype constellation with bovine strain (G10P[14])), although some bovine and bovine-like strains have been found to have other NSP1 (A3 or A13 instead of A11) and NSP3 (T2, T7, or T9 instead of T6) genotypes. Antelope strain RC-18, caprine strain GO34, ovine strain OVR762, and human strains (Ghan-059, KH2288, MG6, Hun5, EGY3399, N-1, BP1062, and V585) have been shown to have bovine backbones, and to be likely of bovine origin through their full-genomic analyses (Afrad et al, 2013;Bányai et al, 2010;Cowley et al, 2013;E1 Sherif et al, 2011;Ghosh et al, 2010;Heylen et al, 2015;Matthijnssens et al, 2009;Mullick et al, 2013). Thus, the genotype constellation of strains HMG035 and NGRBg8 is mostly identical to those of bovine and bovine-like strains.…”