Molecular Epidemiology of Rotavirus in Cats in the United Kingdom

German, A; Iturriza‐Gómara, Miren; Dove, Winifred; Sandrasegaram, M.; Nakagomi, Toyoko; Nakagomi, Osamu; Cunliffe, Nigel A.; Radford, Alan; Morgan, K. L.

doi:10.1128/jcm.02266-14

Cited by 26 publications

(31 citation statements)

References 89 publications

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“…Reports on rotavirus infections in wild felids are lacking, and the scarce reports in domestic cats have not indicated serious impacts of the disease (36), although exceptions exist (37). In a large epidemiological investigation of RVA in cats housed within 25 rescue catteries across the United Kingdom, only 3% of the 1,727 cats sampled were infected (36). Although only eight snow leopards were sampled, the present study shows that the RVA prevalence of ∼67% in snow leopards in the Tost Mountains of Mongolia is surprisingly high compared to existing knowledge.…”

Section: Discussionmentioning

confidence: 99%

Detection and Genetic Characterization of Viruses Present in Free-Ranging Snow Leopards Using Next-Generation Sequencing

et al. 2020

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Snow leopards inhabit the cold, arid environments of the high mountains of South and Central Asia. These living conditions likely affect the abundance and composition of microbes with the capacity to infect these animals. It is important to investigate the microbes that snow leopards are exposed to detect infectious disease threats and define a baseline for future changes that may impact the health of this endangered felid. In this work, next-generation sequencing is used to investigate the fecal (and in a few cases serum) virome of seven snow leopards from the Tost Mountains of Mongolia. The viral species to which the greatest number of sequences reads showed high similarity was rotavirus. Excluding one animal with overall very few sequence reads, four of six animals (67%) displayed evidence of rotavirus infection. A serum sample of a male and a rectal swab of a female snow leopard produced sequence reads identical or closely similar to felid herpesvirus 1, providing the first evidence that this virus infects snow leopards. In addition, the rectal swab from the same female also displayed sequence reads most similar to feline papillomavirus 2, which is the first evidence for this virus infecting snow leopards. The rectal swabs from all animals also showed evidence for the presence of small circular DNA viruses, predominantly Circular Rep-Encoding Single-Stranded (CRESS) DNA viruses and in one case feline anellovirus. Several of the viruses implicated in the present study could affect the health of snow leopards. In animals which are under environmental stress, for example, young dispersing individuals and lactating females, health issues may be exacerbated by latent virus infections.

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Section: Discussionmentioning

confidence: 99%

Detection and Genetic Characterization of Viruses Present in Free-Ranging Snow Leopards Using Next-Generation Sequencing

et al. 2020

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“…Ghanaian G6P [6] human rotavirus recently reported to be the most prevalent genotype among cats in the UK (German et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Evolution of a G6P[6] rotavirus strain isolated from a child with acute gastroenteritis in Ghana, 2012

Agbemabiese

Nakagomi

Suzuki

et al. 2015

Journal of General Virology

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Unusual human G6P [6] rotavirus A (RVA) strains have been reported sporadically in Europe and Africa, but how they evolved was not fully understood. The whole genome of a Ghanaian G6P[6] strain designated PML1965 (2012) was analysed to understand how it evolved in Africa and to learn how its G6 VP7 gene was related to that of rotaviruses of human and artiodactyl origin. The genotype constellation of RVA/Human-wt/GHA/PML1965/2012/G6P[6] was G6-P-[6]-I2-R2-C2-M2-A2-N2-T2-E2-H2. It shared sublineages with G6P[6] strains previously detected in Italy and Africa in all genome segments except the VP6 gene of a few Burkinabe and Cameroonian strains and both the VP6 and NSP4 genes of Guinea Bissau strains. The VP7 gene of the G6P[6] strains appeared to derive from those of human G6P [9] strains, and they were distantly related to the VP7 genes of artiodactyl G6 or human G6P [14] strains. The time of the most recent common ancestor of the VP7 sequences of G6P[6] strains was estimated to be the year 1998. The evolutionary rates of the VP7 genes in bovine and human G6 rotaviruses were 6.93610 24 and 3.42610 23 nucleotide substitutions site 21 year 21 , respectively, suggesting an accelerated adaptive process in the new host. The sequences of the remaining 10 genome segments of PML1965 clustered with those of G2 and G8 human rotaviruses detected in Africa possessing the DS-1-like genetic background.In conclusion, PML1965 evolved from G2 or G8 RVA strains with DS-1-like background, acquiring the G6 VP7 gene from a human G6P[9] RVA and not from an artiodactyl G6 RVA strain.

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“…In pets, rotavirus is occasionally detected during laboratory diagnosis in dogs and cats. Canine rotaviruses detected so far have been found to carry predominantly the G3P[3] antigen combination, whereas feline rotaviruses carry G3P[3], G3P[9] or G6P[9] genotypes [39, 69,70].…”

Section: Epidemiology and Surveillance In Animalsmentioning

confidence: 99%

Zoonotic transmission of rotavirus: surveillance and control

Dóró

Farkas

Martella

et al. 2015

Expert Review of Anti-infective Therapy

101

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Group A rotavirus (Rotavirus A, RVA) is the main cause of acute dehydrating diarrhea in humans and numerous animal species. RVA shows vast diversity and a variety of human strains share genetic and antigenic features with animal origin RVA strains. This finding suggests that interspecies transmission is an important mechanism of rotavirus evolution and contributes to the diversity of human RVA strains. RVA is responsible for half a million deaths and several million hospitalizations worldwide. Globally, two rotavirus vaccines are available for routine use in infants. These vaccines show a great efficacy profile and induce protective immunity against various rotavirus strains. However, little is known about the long-term evolution and epidemiology of RVA strains under selective pressure related to vaccine use. Continuous strain surveillance in the post-vaccine licensure era is needed to help better understand mechanisms that may affect vaccine effectiveness.

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Molecular Epidemiology of Rotavirus in Cats in the United Kingdom

Abstract: . This is the first population-based study of rotavirus in cats and the first report of feline G6P[9], which questions the previous belief that G6P [9] in people is of bovine origin.

Cited by 26 publications

References 89 publications

Detection and Genetic Characterization of Viruses Present in Free-Ranging Snow Leopards Using Next-Generation Sequencing

Detection and Genetic Characterization of Viruses Present in Free-Ranging Snow Leopards Using Next-Generation Sequencing

Evolution of a G6P[6] rotavirus strain isolated from a child with acute gastroenteritis in Ghana, 2012

Zoonotic transmission of rotavirus: surveillance and control

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