Genetic characterization of 27 Y-STR loci with the Yfiler ® Plus kit in the population of Serbia

Zgonjanin, Dragana; Alghafri, Rashed; Antov, Mirjana G.; Stojiljković, Goran; Petković, Stojan; Vuković, Radenko; Drašković, Dragan

doi:10.1016/j.fsigen.2017.07.013

Cited by 15 publications

(10 citation statements)

References 18 publications

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“…This had 32 repeats compared to the King's 33 in marker DYS389II. This haplotype was discovered in the population living in Northern Serbia (Zgonjanin et al 2017). …”

Section: Kinship Analysismentioning

confidence: 84%

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DNA profiling of Hungarian King Béla III and other skeletal remains originating from the Royal Basilica of Székesfehérvár

Olasz

Seidenberg²,

Hummel³

et al. 2018

Archaeol Anthropol Sci

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A few decades after the collapse of the Avar Khaganate (c. 822 AD), Hungarian invaders conquered the Carpathian Basin (c. 862-895 AD). The first Hungarian ruling dynasty, the Árpáds played an important role in European history during the Middle Ages. King Béla III (1172-1196) was one of the most significant rulers of the dynasty. He also consolidated Hungarian dominance over the Northern Balkans. The provostry church of the Virgin Mary (commonly known as the Royal Basilica of Székesfehérvár) played a prominent role as a coronation church and burial place of medieval Hungarian kings. The basilica's building and graves had been destroyed over the centuries. The only royal graves that remained intact were those of King Béla III and his first spouse, Anna of Antioch. These graves were discovered in 1848. We defined the autosomal STR (short tandem repeat) fingerprints of the royal couple and eight additional individuals (two females and six males) found in the Royal Basilica. These results revealed no evidence of first-degree relationship between any of the investigated individuals. Y-chromosomal STR profiles were also established for all the male skeletons. Based upon the Y-chromosomal data, one male skeleton showed an obvious patrilineal relationship to King Béla III. A database search uncovered an existing Y-chromosomal haplotype, which had a single-repeat difference compared to that of King Béla. It was discovered in a person living in an area close to Hungary. This current male line is probably related paternally to the Árpád Dynasty. The control region of the mitochondrial DNA was determined in the royal couple and in the remains of the inferred relative. The mitochondrial results excluded sibling relationship between the King and the patrilineal relative. In summary, we successfully defined a Y-chromosomal profile of King Béla III, which can serve as a reference for the identification of further remains and disputed living descendants of the Árpád Dynasty. Among the examined skeletons, we discovered an Árpád member, whose exact affiliation, however, has not yet been established.

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“…This had 32 repeats compared to the King's 33 in marker DYS389II. This haplotype was discovered in the population living in Northern Serbia (Zgonjanin et al 2017). …”

Section: Kinship Analysismentioning

confidence: 84%

“…The closest haplotype to that of King Béla III was found in the YHRD and showed a one-repeat difference in marker DYS389II. The person with this haplotype is living in the population of present-day Northern Serbia (Zgonjanin et al 2017 Fig. 3 The inverse relationship between the STR fragment size and peak height.…”

Section: Discussionmentioning

confidence: 99%

DNA profiling of Hungarian King Béla III and other skeletal remains originating from the Royal Basilica of Székesfehérvár

Olasz

Seidenberg²,

Hummel³

et al. 2018

Archaeol Anthropol Sci

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“…A neighbor‐joining (NJ) phylogenetic tree was constructed on the basis of the Rst genetic matrixes using the Molecular Evolutionary Genetics Analysis Version 6.0 (MEGA 6.0) (Tamura et al, 2013). The 67 reference groups included 22 Chinese populations (Fan et al, 2019; Gayden et al, 2012; Hu et al, 2017; Ji et al, 2017; Kim et al, 2001; Liu et al, 2019; Luo et al, 2019; Song et al, 2020; Sun et al, 2019; Tang et al, 2020; Xie et al, 2019; Yang et al, 2014; Yin et al, 2020; Zhang et al, 2017; Zhou et al, 2016) and 45 worldwide populations (Aliferi et al, 2018; D'Atanasio et al, 2019; Füredi et al, 1999; García et al, 2016; Hallenberg et al, 2005; Henry et al, 2019; Jankauskiene et al, 2017; Jankova et al, 2019; Pickrahn et al, 2016; Purps et al, 2014; Rapone et al, 2016; Shonhai et al, 2020; Spólnicka et al, 2017; Watahiki et al, 2019; Zgonjanin et al, 2017; Zhabagin et al, 2019) and the information about these groups are listed in Table .…”

Section: Methodsmentioning

confidence: 99%

RETRACTED: Genetic structure and forensic characterization of 36 Y‐chromosomal STR loci in Tibeto‐Burman‐speaking Yi population

Song

Wang²,

Zhang

et al. 2021

Molec Gen & Gen Med

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Background Male‐specifically inherited Y‐STRs have been widely used in population genetics and forensic investigations. Methods We genotyped and analyzed Y chromosome haplotypes of 408 unrelated Tibeto‐Burman‐speaking Yi male individuals from Guizhou using Goldeneye® Y‐PLUS kit. Population comparisons between the Guizhou Yi and 67 reference groups were performed via the AMOVA, MDS, and phylogenetic relationship reconstruction. Results A total of 389 alleles and 396 haplotypes could be detected, and the allelic frequencies ranged from 0.0025 to 0.9875. The haplotype diversity, random match probability, and discrimination capacity values were 0.9999, 0.0026, and 0.9900, respectively. The gene diversity (GD) of 36 Y‐STR loci in the studied group ranged from 0.0248 (DYS645) to 0.9601 (DYS385a/b). Our newly genotyped Yi samples show a close affinity with other Tibeto‐Burman speaking groups in China and Southeast Asia. Conclusions The population stratification was almost consistent with the geographic distribution and language‐family, both among Chinese and worldwide ethnic groups. Our data may provide useful information for paternal lineage in the forensic application and population genetics, as well as evidence for archaeological and historical research.

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“…While the addition of a number of RM Y-STRs greatly increased the discrimination capacity (DC) compared with the Yfiler multiplex previously implemented in Bahrain, a DC of 87.5% remains very low compared with most populations, for example Serbia 99.9% (Zgonjanin et al 2017 ), Upper Austria and Salzburg 99.7% (Pickrahn et al 2016 ), Mongolia 98.9% (Wang et al 2019 ), Italy 98.5% (Rapone et al 2016 ), US Caucasians 98.5% (Gopinath et al 2016 ) , Daur 96.55% (Wang et al 2019 ) and Saudi Arabia 95.3% (Khubrani et al 2018 ), although the highly bottle-necked Greenland population is lower at 79.0% (Olofsson et al 2015 ). There are many shared haplotypes in the Bahraini sample, despite precautions to exclude males sharing common patrilineal ancestry in the last three generations.…”

Section: Discussionmentioning

confidence: 99%

Geographical structuring and low diversity of paternal lineages in Bahrain shown by analysis of 27 Y-STRs

et al. 2020

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We have determined the distribution of Y-chromosomal haplotypes and predicted haplogroups in the ethnically diverse Kingdom of Bahrain, a small archipelago in the Arabian Gulf. Paternal population structure within Bahrain was investigated using the 27 Y-STRs (short tandem repeats) in the Yfiler Plus kit to generate haplotypes from 562 unrelated Bahraini males, sub-divided into four geographical regions—Northern, Capital, Southern and Muharraq. Yfiler Plus provided a significant improvement over the 17-locus Yfiler kit in discrimination capacity (from 77% to 87.5% overall), but discrimination capacity differed widely between regions from 98.4% in Muharraq to 75.2% in the Northern region, an unusually low value possibly resulting from recent rapid population expansion. Clusters of closely related male lineages were seen, with only 79.4% of donors displaying unique haplotypes and 59% of instances of shared haplotypes occurring within, rather than between, regions. Haplogroup prediction indicated diverse origins of the population with a predominance of haplogroups J2 and J1, both typical of the Arabian Peninsula, but also haplogroups such as B2 and E1b1a likely originating in Africa, and H, L and R2 likely indicative of migration from South Asia. Haplogroup frequencies differed significantly between regions, with J2 significantly more common in the Northern region compared with the Southern, possibly due to differential settlement by Baharna and Arabs. Our study shows that paternal lineage population structure can exist even over small geographical scales, and that highly discriminating genetic tools are required where rapid expansions have occurred within tightly bounded populations.

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Genetic characterization of 27 Y-STR loci with the Yfiler ® Plus kit in the population of Serbia

Cited by 15 publications

References 18 publications

DNA profiling of Hungarian King Béla III and other skeletal remains originating from the Royal Basilica of Székesfehérvár

DNA profiling of Hungarian King Béla III and other skeletal remains originating from the Royal Basilica of Székesfehérvár

RETRACTED: Genetic structure and forensic characterization of 36 Y‐chromosomal STR loci in Tibeto‐Burman‐speaking Yi population

Geographical structuring and low diversity of paternal lineages in Bahrain shown by analysis of 27 Y-STRs

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