2018
DOI: 10.1016/j.gde.2018.01.002
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Genetic basis of diabetic kidney disease and other diabetic complications

Abstract: Diabetic kidney disease and other long-term complications are common in diabetes, and comprise the main cause of co-morbidity and premature mortality in individuals with diabetes. While familial clustering and heritability have been reported for all diabetic complications, the genetic background and the molecular mechanisms remain poorly understood. In recent years, genome-wide association studies have identified a few susceptibility loci for the renal complications as well as for diabetic retinopathy, diabeti… Show more

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Cited by 32 publications
(16 citation statements)
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“…It is now clear that there is large variability in susceptibility of widely used inbred mouse strains to albuminuria and glomerulosclerosis in DN. Moreover, susceptibility loci for DN have been identified in humans . It is possible that the genetic changes that make Dahl SS rats a good model for studies of hypertension result in enhanced TRPC6 signaling somewhere within the animal (possibly but not necessarily within glomeruli).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…It is now clear that there is large variability in susceptibility of widely used inbred mouse strains to albuminuria and glomerulosclerosis in DN. Moreover, susceptibility loci for DN have been identified in humans . It is possible that the genetic changes that make Dahl SS rats a good model for studies of hypertension result in enhanced TRPC6 signaling somewhere within the animal (possibly but not necessarily within glomeruli).…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, susceptibility loci for DN have been identified in humans. 45 It is possible that the genetic changes that make Dahl SS rats a good model for studies of hypertension 38 result in enhanced TRPC6 signaling somewhere within the animal (possibly but not necessarily within glomeruli). In this regard, Dahl SS rats typically exhibit slightly increased urine albumin excretion, even on low-salt diets.…”
Section: Discussionmentioning
confidence: 99%
“…SNP могут влиять на предрасположенность к различным заболеваниям, скорость и тяжесть развития осложнений [6,7], а также чувствительность к лекарственным препаратам [8,9], что было показано во многих работах, в том числе изучающих СД2, по данным которых его наследуемость в некоторых семьях достигает 80% [10]. На современном этапе в арсенале исследователей имеются 4 основных подхода-стратегии к изучению роли SNP в патогенезе СД2, а именно:…”
Section: актуальностьunclassified
“…Genome-wide association studies (GWAS) have had limited success in identifying genetic factors that predict kidney disease progression, despite major financial investment and the study of more than 10,000 patients. This lack of success is likely due to inter-individual heterogeneity in kidney disease progression, even in disease subtypes characterized by similar aetiology 1 . The progression of diabetic kidney disease, for example, is highly variable and the rate of decline in kidney function only partly correlates with urine albumin to creatinine ratio (ACR), blood pressure and glycaemic control 2,3 .…”
mentioning
confidence: 99%