In the development of type 2 diabetes (T2D), an important role is played by a combination of environmental factors (hypodynamia, hypernutrition, etc.) and genetic variants that predispose the development of the disease. The contribution of inherited traits to the development of T2D can reach 80%, which is confirmed by the results of a number of published studies. At the same time, the multifactorial and polygenetic nature of T2D makes it difficult to establish direct cause-effect relations between individual genetic variants and specific metabolic changes. This explains a large number of studies and a long ongoing search for the most convenient and effective strategy for assessing the role of single nucleotide polymorphisms (SNP), the main type of genetic variation in the human genome. Involvement of specialists from various fields and the emergence of many methods for processing and interpreting data have led to the parallel development of scientific approaches. In this review of the main approaches (except mathematical ones) their characteristics will be described and the results obtained with their help will be evaluated, with special focus on new features of modern methods of genome editing, in particular the CRISPR/Cas9 system, and the future prospects in this area.
The increasing role of migration in the world makes the integration of migrants into host societies a crucial social process. In the long run, integration is closely related to the topic of the second generation of migrants and their relative well-being in society. In Russia, which attracts a large number of migrants, the integration of the second generation is also very important but the understanding of it is fragmented due to the small number of relevant studies. The task of obtaining relevant data on migrants' descendants and their participation in social and economic life requires taking into account the wealth of foreign experience in studying this topic.This paper provides an overview of approaches to the study of the second generation of migrants in the United States, Canada and Western European countries. The review is based on analytical and methodological publications of national statistical agencies and international organizations (UN, OECD, Eurostat), metadata from special sample surveys and a number of academic articles. The authors discusses the main data sources used to estimate the number of second-generation migrants and to provide information on their socio-economic characteristics, such as censuses and microcensuses, regular labour force surveys and ad hoc sample surveys. The article describes nuances in the definition and evolution of the concept of «second generation» in the national statistical systems. The results of studies on the social mobility of descendants of immigrants are summarised.In conclusion, we offer practical recommendations for modernizing the system of statistical recording of migration in Russia based on the long-term foreign experience of studying the second generation of migrants.
Miscibility of high density polyethylene and modifiers was evaluated using polymer-polymer interaction parameter and determined with the help of inverse gas chromatography. Mechanical, rheological properties and melting point changes were investigated. Measurements of mechanical properties showed that alloying of high density polyethylene with different oligoesters may produce higher strength and elongation than pure PE. The results obtained showed that compatibility of PE and additives may influence overall characteristics of the compositions. Mechanical properties of compatible alloys change monotonously when the concentration of modifiers increases. For unmiscible systems. the relationship between mechanical properties and oligoester concentration appears to display a curve with extremum. The performed study made it possible to choose optimum systems for use as an optical cable.
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