Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography

Nemoto, Masami; Nishimura, Rimei; Sasaki, Takashi; Hiki, Yoshito; Miyashita, Yumi; Nishioka, Makiko; Fujimoto, Kei; Sakuma, Toru; Ohashi, Toya; Fukuda, Kunihiko; Eto, Yoshikatsu; Tajima, Naoko

doi:10.1186/1475-2840-6-23

Cited by 75 publications

(42 citation statements)

References 25 publications

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“…The 8-isoprostanes are formed during the free radical-mediated oxidation of arachidonic acid (12), which is ubiquitously distributed in the cell membrane, and 8-isoprostanes have been reported as a marker of whole body oxidative stress (13). Our results indicate that the whole body oxidative stress was significantly increased in patients with type 2 diabetes, and this was associated with a higher CACS, as reported previously in Western subjects (4) and in Japanese subjects with a gene associated with susceptibility to oxidative stress (14).…”

Section: Discussionsupporting

confidence: 87%

Association of Coronary Artery Calcification with MDA-LDL-C/LDL-C and Urinary 8-Isoprostane in Japanese Patients with Type 2 Diabetes

et al. 2014

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Objective Oxidative stress has been implicated in the development of coronary artery calcification (CAC). However, there are few reports on this issue in Japanese patients with diabetes. In this study, we examined the association of the CAC score (CACS) with oxidative stress markers. Methods The study subjects were 163 Japanese patients with type 2 diabetes (75 men and 88 women). The CACS (Agatston unit: AU) was measured by multi-detector computed tomography (MDCT), and the oxidative stress markers, such as the urinary 8-isoprostane and 8-hydroxydeoxyguanosine (8-OHdG) and serum malondialdehyde (MDA)-LDL cholesterol were measured. The relationships between CACS and oxidative stress markers were statistically analyzed. Results Compared with the CACS 0-400 AU group (n=132), the age, duration of diabetes, urinary 8-isoprostane levels, serum MDA-LDL-C/LDL-C and maximum intima media thickness (IMT) were higher, and body mass index and HbA1c level were lower, in the CACS >400 AU group (n=31). The multiple logistic regression analysis showed that a CAC >400 AU was independently associated with the urinary 8-isoprostane (>median) (OR=2.54, 95% CI=1.03-6.32, p=0.044), MDA-LDL-C/LDL-C (>median) (OR=2.62, 95% CI=1.07-6.40, p=0.035) and HbA1c (>median) (OR=0.32, CI=0.12-0.87, p<0.025). Focusing on oxidative stress, a higher MDA-LDL-C/LDL-C (p=0.026) and a higher urinary 8-isoprostane level (p=0.074) were associated with the CACS. Conclusion The CACS was found to be independently associated with the MDA-LDL-C/LDL-C and urinary 8-isoprostane levels in Japanese patients with type 2 diabetes.

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Section: Discussionsupporting

confidence: 87%

Association of Coronary Artery Calcification with MDA-LDL-C/LDL-C and Urinary 8-Isoprostane in Japanese Patients with Type 2 Diabetes

et al. 2014

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“…In both T1DM and T2DM, the Val/Val genotype is associated with an increased risk of diabetic nephropathy (Mollsten et al, 2007;Nomiyama et al, 2003). Another study in 91 T2DM patients found no association between SOD2 genotype and coronary artery calcium score (Nemoto et al, 2007). The results of these studies are difficult to compare due to the different co-morbidities investigated.…”

Section: Diabetesmentioning

confidence: 94%

Relationships between single nucleotide polymorphisms of antioxidant enzymes and disease

Crawford

Fassett

Geraghty

et al. 2012

Gene

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“…Decreased GPX-1 activity is associated with increased risk of atherosclerosis (Espinola-Klein et al 2007). The GPX1 gene polymorphisms associated with decreased GPX1 enzymatic activity have been associated with increased risk of atherosclerosis (Hamanishi et al 2004;Nemoto et al 2007;Tang et al 2008;Winter et al 2003). Glutathione stransferase (GST) is another enzyme that plays a key role in cellular antioxidant defence mechanisms.…”

Section: Genes Associated With Oxidative Stressmentioning

confidence: 99%

Molecular genetics of atherosclerosis

2009

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Atherosclerosis is a complex multifocal arterial disease involving interactions of multiple genetic and environmental factors. Advances in techniques of molecular genetics have revealed that genetic polymorphisms significantly influence susceptibility to atherosclerotic vascular diseases. A large number of candidate genes, genetic polymorphisms and susceptibility loci associated with atherosclerotic diseases have been identified in recent years and their number is rapidly increasing. In this review we focus on some of the major candidate genes and genetic polymorphisms associated with human atherosclerotic vascular diseases.

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Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography

Cited by 75 publications

References 25 publications

Association of Coronary Artery Calcification with MDA-LDL-C/LDL-C and Urinary 8-Isoprostane in Japanese Patients with Type 2 Diabetes

Association of Coronary Artery Calcification with MDA-LDL-C/LDL-C and Urinary 8-Isoprostane in Japanese Patients with Type 2 Diabetes

Relationships between single nucleotide polymorphisms of antioxidant enzymes and disease

Molecular genetics of atherosclerosis

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