Genetic Association and Functional Characterization of a Variant in the McPh1 Gene in Bipolar Disorder and Schizophrenia

Aleissa, Mariam; Sharp, Sally I.; Fiorentino, Alessia; O’Brien, Niamh; Bass, Nicholas; Curtis, David; McQuillin, Andrew

doi:10.1016/j.euroneuro.2017.08.330

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“…We found that the highest tail moment and tail length in psychiatric diseases. Psychiatric diseases can cause increased DNA damage (Ahmadimanesh, et al, 2019;Aleissa et al, 2019). Studies provide that evidence of high oxidative stress statuses and inadequate DNA repair capacities in patients with psychiatric diseases (Toprak et al, 2018;Panwar et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Analysis of Genotoxic Damage in Different Diseases

Göney¹,

Halisdemir²

2021

jgehes

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Aim: Research has revealed that diseases changed the repair mechanism of DNA chain breaks. Recent studies indicate that genomic instability results in cancer. The present study aimed to assess the association between diseases and DNA damage measured with the comet assay in humans. Method:In a cross-sectional study the level of genotoxic damage was evaluated in peripheral blood samples by simple random sampling method in Turkish adults using Single Cell Gel Electrophoresis assay. The results of possible DNA damage levels of disease groups were compared with the results of healthy people. A p-value of less than 0.01 was considered as statistically significant. Results: 128 (52 women and 76 men) participated in the study. The tail moment was 1.39±1.21 in healthy groups and 1.41±0.91 in patient groups. Our result showed that participants with hepatitis, thyroid dysfunctions, and psychiatric diseases had statistically significant differences in DNA damage compared to healthy ones. Conclusion and Suggestions:Our findings suggest that patients with hepatitis, thyroid dysfunctions, and psychiatric diseases are at risk of genotoxic damage. Genotoxicity tests have gained importance in early biomonitoring of cancer. Therefore, the relationship between diseases and cancer development should be investigated with different genotoxic experiments.

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Section: Discussionmentioning

confidence: 99%