GENETIC ASPECTS OF IgD EXPRESSION: III. FUNCTIONAL IMPLICATIONS OF THE SEQUENCE AND ORGANIZATION OF THE Cδ GENE

Tucker, Philip W.; Cheng, Hwei-Ling; Richards, Julia E.; Fitzmaurice, Leona; Mushinski, J. Frederic; Blattner, Frederick R.

doi:10.1111/j.1749-6632.1982.tb25661.x

Cited by 11 publications

(5 citation statements)

References 34 publications

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“…Genotypes are only inferred since segregation does not ordinarily occur in allotetraploids. 14 Immunoglobulin D (IgD) was discovered in human serum in 1965 (1), and the corresponding mouse Ig was identified subsequently (2,3). In both the mouse and the human, IgD is a predominant surface component of B cells and is only a minor component of serum Ig (1,4).…”

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confidence: 99%

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Human Immunoglobulin D: Genomic Sequence of the Delta Heavy Chain

White

Shen

Word

et al. 1985

Science

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The DNA coding for the human immunoglobulin D(IgD) heavy chain (delta, delta) has been sequenced including the membrane and secreted termini. Human delta, like that of the mouse, has a separate exon for the carboxyl terminus of the secreted form. This feature of human and mouse IgD distinguishes it from all other immunoglobulins regardless of species or class. The human gene is different from that of the mouse; it has three, rather than two, constant region domains; and its lengthy hinge is encoded by two exons rather than one. Except for the third constant region, the human and mouse genes are only distantly related.

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“…As a result, mouse IgD is observed in" dimeric as well as tetrameric forms (12,13). (iii) The secreted terminus is encoded on a separate exon, which is distal to the body of the gene rather than as an extension of the carboxyl terminal domain as is the case in all other immunoglobulins (14).…”

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confidence: 99%

Human Immunoglobulin D: Genomic Sequence of the Delta Heavy Chain

White

Shen

Word

et al. 1985

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“…IgM and IgD reportedly act together in the capping of antigen [34], and DNA sequences coding identical cytoplasmic tails and similar transmembrane [35] 5 References…”

Section: Discussionmentioning

confidence: 99%

Suppression of specific IgM, IgA and IgG responses in mice treated with anti‐6 from birth

Wathen

Manning

1986

Eur J Immunol

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In contrast to previous studies, we report that heterologous anti-delta antibodies can act as a powerful multi-class humoral immunosuppressant. Primary direct plaque-forming cell (IgM) responses of BALB/c mice injected from birth with a rabbit anti-delta antiserum were reduced to 3% of control levels against a T-dependent antigen (sheep red blood cells), and to 2% against a T-independent antigen (dextran); IgA responses against 2 intraduodenal injections of cholera toxin were reduced to 7% of control levels. Other secondary immune responses of anti-delta-suppressed mice were suppressed to a lesser degree. IgM plaque responses generated by 2 injections of sheep red cells, for example, were reduced to 50% of control levels, with reduction of the corresponding IgG response to 42%. The multi-class suppression observed indicates a clonal differentiation pathway in which the IgD+ cell develops into IgM-, IgA- and IgG-secreting cells. In light of reports that the IgD+ cell is antigen sensitive, our demonstration that IgD is capable of delivering the same sort of immunosuppressive signal in response to anti-heavy chain antibodies that IgM delivers also suggests, though it does not establish, an antigen-receptor role for IgD.

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“…This allowed assignment of the a l gene to an upstream locus and a 2 to a downstream locus on the chromosome. However, there is an apparent absence of the C ô 2 domain in the structure proposed for mouse IgD based on nucleotide sequencing of the δ chain gene (Tucker et al, 1980(Tucker et al, , 1982. The entire covalent structure of a human IgD molecule (IgD WAH) has been reported including the complete amino acid sequences of the δ chain , the λ light chain (Y. Takahashi et ai, 1983), and the structures of the asparagine-linked GlcN and the O-linked GalNoligosaccharides (Mellis and Baenziger, 1983a,b).…”

Section: B Cloning and Nucleotide Sequencing Of Immunoglobulin Genesmentioning

confidence: 99%

Alpha, Beta, Gamma, Omega—The Structure of the Plasma Proteins

Putnam¹

1984

The Plasma Proteins

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GENETIC ASPECTS OF IgD EXPRESSION: III. FUNCTIONAL IMPLICATIONS OF THE SEQUENCE AND ORGANIZATION OF THE Cδ GENE

Cited by 11 publications

References 34 publications

Human Immunoglobulin D: Genomic Sequence of the Delta Heavy Chain

Human Immunoglobulin D: Genomic Sequence of the Delta Heavy Chain

Suppression of specific IgM, IgA and IgG responses in mice treated with anti‐6 from birth

Alpha, Beta, Gamma, Omega—The Structure of the Plasma Proteins

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