Genetic Aspects of Antibody Responses in Chickens to Different Classes of Antigens ,

Abstract

Six breeding groups of chickens, each characterized by a different haplotype of the B blood group system, were challenged with different classes of antigens, namely Newcastle disease vaccine (ND), infectious bronchitis vaccine (IB), infectious bursal disease viral agent (IBD), Salmonella pullorum antigen (P), and sheep red blood cells (SRBC). Parents were challenged at 20 weeks of age, and their offspring were challenged at 3 weeks of age. Blood samples were taken from the parents at 1 week after challenge, and from the offspring at 1, 2, 3, and 4 weeks after challenge for determination of antibody titers to each antigen. The offspring were also challenged at 8 weeks of age in the wing-web with Rous sarcoma virus (RSV). Tumor scores were taken weekly on individual chickens for the next 10 weeks. There were significant differences (P less than .01) between breeding groups of parents for antibody titer responses to ND, IB, P, and SRBC. There were significant differences (P less than .05) between the breeding groups of offspring for antibody titer responses to ND, IB, IBD, P, and SRBC. There were significant (P less than .01) differences between the breeding groups in the accumulative tumor scores over the 10-week period. The lines that cause regression of Rous sarcomas (R-lines) were significantly (P less than .01) superior in resisting tumor growth to those lines that allow progressive growth of tumors (Pr-lines). The only antigen to which the R-lines gave significantly (P less than .01) higher titers of antibody responses than the Pr-lines was SRBC.

Genetic Associations of Body Weight and Immune Response with the Major Histocompatibility Complex in White Leghorn Chicks

“…RSV response was not significantly associated with differences in body weight or SRBC antibody titer. Gyles et al (1986) found a positive genetic association between high antibody response to SRBC and regression of RSV tumors. The differences between the studies may result from the method of formation of the sublines tested.…”

“…The differences between the studies may result from the method of formation of the sublines tested. In the Gyles et al (1986) study, selection was first based on RSV tumor response; subsequently, sublines were formed based on Ea-B type. Genetic control of tumor response in those lines was due to the R-Rs-1 gene.…”

Divergent selection for humoral immune responsiveness in chickens: distribution and effects of major histocompatibility complex types

“…Interestingly, these authors reported that the most frequent B-haplotype in the H line was the 21, which shares B-F antigens with the 121 B-haplotype, which was also predominant in our H line (Pinard and Hepkema, 1992). Typing for MHC antigens in lines of mice divergently selected for Ab response to SRBC (Biozzi et al, 1979) also revealed 2 distinct haplotypes in the 2 lines (Colombani et al, 1979 (Palladino et al, 1977;Gyles et al, 1986;Kim et al, 1987;Lamont and Dietert, 1990). Significant interactions between MHC and the selected background genome were also reported in a similar selection experiment to ours (Dunnington et al, 1989).…”

Genetic Variation in Resistance of Turkeys to Experimental Infection with Newcastle Disease Virus

“…La sublinea F tuvo los mas altos titulos de anticuerpos HI, seguida en un orden descendente por las lineas RBC2, RBC1 y la sublinea E. No se encontr6 una correlacion aparente entre la respuesta de anticuerpos y la mortalidad despu&s del desafio con el virus de la enfermedad de (3,4). The genetic variation in the antibody response of chickens to ND vaccine has also been noted (5,9). Recently, subline E and line RBC1 turkey poults were examined for antibody responses to ND vaccine in a five-trial study (12).…”