Genetic and epigenetic instability induced by betel quid associated chemicals

Muthukumaran, Rajendra Bose; Bhattacharjee, Pritha; Bhowmick, Priya; Zote, Lalrinawma; Malsawmtluangi,; Kumar, Nachimuthu Senthil; Jahau, Lalrintluanga; Cooke, Marcus S.; Hu, Chiung‐Wen; Chao, Mu‐Rong

doi:10.1016/j.toxrep.2023.02.001

Cited by 5 publications

(2 citation statements)

References 113 publications

(214 reference statements)

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“…There are several articles describing the effects caused by areca nut (AN) previously [6][7][8][9]. In addition, some of the review articles focused on specific aspects, such as carcinogenic effects [10], addiction [11], AN cessation [12], genetic and epigenetic instability [13], submucous fibrosis progression [14], oral cancer [15] and liver disease [4]. We here review the results of these reports and evaluate the controversial roles of AN.…”

Section: The History and Usage Of Anmentioning

confidence: 99%

The Controversial Roles of Areca Nut: Medicine or Toxin?

Liu

Chang

2023

IJMS

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Areca nut (AN) is used for traditional herbal medicine and social activities in several countries. It was used as early as about A.D. 25-220 as a remedy. Traditionally, AN was applied for several medicinal functions. However, it was also reported to have toxicological effects. In this review article, we updated recent trends of research in addition to acquire new knowledge about AN. First, the history of AN usage from ancient years was described. Then, the chemical components of AN and their biological functions was compared; arecoline is an especially important compound in AN. AN extract has different effects caused by different components. Thus, the dual effects of AN with pharmacological and toxicological effects were summarized. Finally, we described perspectives, trends and challenges of AN. It will provide the insight of removing or modifying the toxic compounds of AN extractions for enhancing their pharmacological activity to treat several diseases in future applications.

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Section: The History and Usage Of Anmentioning

confidence: 99%

The Controversial Roles of Areca Nut: Medicine or Toxin?

Liu

Chang

2023

IJMS

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“…Furthermore, China stands as the second-largest producer of areca nut globally 3 . Despite its popularity, areca nut is classi ed as carcinogenic to humans and has been linked to a range of detrimental health effects, including carcinogenicity 4 , genetic and epigenetic instability 5 , sub-mucous brosis progression 6 , oral cancer 7 , and liver disease 8 .…”

Section: Introductionmentioning

confidence: 99%

Brief psychotic disorder caused by areca nut use: a case report

Li,

et al. 2023

Preprint

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Background: Areca Nut (AN) is the fourth most commonly abused drug after nicotine, ethanol, and caffeine, due to its psychoactive properties provided by bioactive substances. Although previous studies have demonstrated AN’s anxiolytic-like activity and potential benefits in ameliorating symptoms of depression and schizophrenia, there remains limited awareness regarding its association with brief psychotic disorder. Case Presentation: This case report presents the clinical profile of a 30-year-old male patient with a history of betel nut chewing for the past 2 years, who exhibited sudden onset delusions, hallucinations, and disorganized speech and behavior upon increasing the dosage of betel nut consumption. The patient displayed a positive response to antipsychotic treatment, and symptoms resolved upon discontinuation of betel nut consumption. However, one month after discharge, the patient experienced a recurrence of auditory hallucinations upon resuming betel nut chewing. Through counseling and support, the importance of abstaining from betel nut use and maintaining medication compliance was emphasized, resulting in no recurrence of psychotic symptoms during the six-month follow-up. Conclusion: This case report highlights the potential role of betel nut in triggering brief psychotic disorder, especially when the chewing dosage is abruptly increased. It underscores the importance of considering betel nut as a potential precipitant of acute psychiatric disorders in clinical settings.

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