Genetic and Environmental Risk Factors for Isolated Hemangiomas in Infants

Materna‐Kiryluk, Anna; Wiśniewska, Katarzyna; Więckowska, Barbara; Wróblewska-Seniuk, Katarzyna; Jaroszewska-Świątek, Beata; Helwich, Ewa; Latos‐Bieleńska, Anna

doi:10.3390/children7100150

Cited by 8 publications

(13 citation statements)

References 21 publications

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“…There are no established risk factors or racial predispositions for isolated congenital haemangiomas, unlike infantile haemangiomas, where female sex, white non-Hispanic ethnicity, prematurity and low birth weight are known risk factors. Meanwhile, in congenital haemangiomas linked to genetic syndromes, a familial predisposition is expected 10…”

Section: Discussionmentioning

confidence: 99%

Rapidly involuting congenital haemangioma: diagnostic and therapeutic approach regarding two case reports

et al. 2022

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Two unrelated neonates were born with a large purplish congenital mass of the thigh and forearm. Both showed signs of heart dysfunction, and one of them had anaemia and thrombocytopenia. The imaging assessment of the lesions showed well-defined subcutaneous solid masses with an exuberant vascular component. Both were kept under surveillance and maintenance therapy. A progressive dimensional reduction of the lesions supported the diagnosis of rapidly involuting congenital haemangioma (RICH). RICH is a rare vascular tumour that presents as a congenital purplish bulky mass. The diagnosis depends on the clinical evaluation of the lesion and the imaging characterisation of its solid components and vascular network. RICH may be complicated by high-output heart failure, anaemia and thrombocytopenia. Despite its exuberant presentation, it undergoes involution in the first year of life; therefore, early invasive therapies should be avoided. It is essential to detect any dimensional increase, suggesting more aggressive diagnoses, such as kaposiform haemangioendothelioma.

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Section: Discussionmentioning

confidence: 99%

Rapidly involuting congenital haemangioma: diagnostic and therapeutic approach regarding two case reports

et al. 2022

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“…Its pathogenesis and exact etiology are not yet fully understood. Premature birth, low‐birth weight, vaginal bleeding in early pregnancy, the use of progesterone, preeclampsia, and placenta previa are all risk factors for IH 5 . For superficial IH, the current recommended treatment involves a wait‐and‐see approach.…”

Section: Discussionmentioning

confidence: 99%

“…Premature birth, low‐birth weight, vaginal bleeding in early pregnancy, the use of progesterone, preeclampsia, and placenta previa are all risk factors for IH. 5 For superficial IH, the current recommended treatment involves a wait‐and‐see approach. However, research reports indicate that up to approximately 69% of untreated or inadequately treated IH cannot be completely resolved.…”

Section: Discussionmentioning

confidence: 99%

“…5 For superficial IH, the current recommended treatment involves a wait-and-see approach. However, research reports indicate that up to approximately 69% of untreated or inadequately treated IH cannot be completely resolved.…”

mentioning

confidence: 99%

“…5 Comparison of adverse reactions for six groups [n (%)] Note: *Short-term adverse reactions include cyanosis, erythema, edema, blisters, and so forth. *Long-term adverse reactions include ulcers, pigmentation, leftover fibrous fatty scars and loose skin, and so forth.…”

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confidence: 99%

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An exploration of optimal time and safety of 595‐nm pulsed dye laser for the treatment of early superficial infantile hemangioma

Hui-yi

Shi

Jiang

et al. 2022

Dermatologic Therapy

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Infantile hemangioma (IH) is the most common benign vascular tumor that occurs in infants and young children. Studies have shown laser therapy to reduce the proliferation of superficial IH and promote its regression, but the optimal timing for treatment has not been determined. Our study explores the timing and safety of 595‐nm pulsed dye laser (PDL) treatment for early superficial IH. We retrospectively analyzed 180 cases of superficial IH treated with 595‐nm PDL. Data was organized according to patient age at the first visit. Six months after the initial treatment, patients were evaluated using a grade IV classification method, and the clinical curative effect of each group was calculated. The number of laser treatments and the occurrence of adverse reactions were recorded simultaneously. The overall effective and cure rates were 98.3% and 84.4%, respectively, with no significant difference in rates between groups (p > 0.05). There was a statistically significant difference in the number of laser treatments among the age groups (p < 0.05). The average laser frequency: “0–2 months group” < “2–4 months group” < “4–6 months group.” The overall incidence of adverse reactions was 11.1%, and 12 (6.7%) cases had short‐term adverse reactions, with no statistically significant differences between groups (p > 0.05). Eight cases had long‐term adverse reactions. This difference between groups was statistically significant (p < 0.05). Younger children (≤2 months of age) receiving 595‐nm PDL treatment for IH require relatively fewer treatment times than other children (>2 months of age), have a shorter course of disease, experience better curative effect, and have fewer sequelae reactions.

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