Genetic and environmental influences on urinary incontinence: a Danish population‐based twin study of middle‐aged and elderly women

Rohr, Gitte; Kragstrup, Jakob; Garcı́a-Dorado, David; Christensen, Kaare

doi:10.1111/j.0001-6349.2004.00635.x

Cited by 48 publications

(29 citation statements)

References 23 publications

(30 reference statements)

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“…Hereditary genetic factors probably predispose for all incontinence types (34)(35)(36). For SUI, there is also a substantial influence of environmental factors such as childbirth, obesity and the process of aging (34).…”

Section: Urinary Incontinencementioning

confidence: 99%

Long-term follow-up of the retropubic tension-free vaginal tape procedure

et al. 2013

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Section: Urinary Incontinencementioning

confidence: 99%

Long-term follow-up of the retropubic tension-free vaginal tape procedure

et al. 2013

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“…Increasing evidence suggests that genetic factors play an important role in the occurrence of UI (Altman et al, 2008;Hannestad et al, 2004;Rohr et al, 2004;Wennberg et al, 2011), as well as major depression (Sullivan et al, 2000), and RECEIVED (Bouchard, 2004;Loehlin, 1992). However, the contribution of genetic and environmental factors to the comorbidity of incontinence and depression/neuroticism has not been investigated.…”

mentioning

confidence: 99%

Depression, Neuroticism, and Urinary Incontinence in Premenopausal Women: A Nationwide Twin Study

et al. 2013

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Previous studies have found that major depression and neuroticism are positively associated with urinary incontinence (UI). However, the genetic contribution to these associations has never been investigated. In 2005, a total of 14,094 female twins born 1959-1985 in the Swedish Twin Registry participated in a comprehensive survey on common exposures and complex diseases. Structured questions provided information on UI, depressive symptoms, major depression, and neuroticism. A logistic regression model based on generalized estimating equations (GEE) was used to estimate odds ratios (ORs) with 95% confidence intervals (CIs). Environmental and genetic influences were assessed in co-twin control analyses and quantitative genetic analyses, which were also used to determine the proportion of the phenotypic correlation explained by familial factors. Major depression, depressive symptoms, and neuroticism were positively associated with all UI subtypes (overall, stress, urge, and mixed UI). In a trivariate Cholesky model with neuroticism, depressive symptoms (or depression), and UI a modest genetic correlation was found between indicators of depression and overall, or stress, UI. The majority of this correlation was independent from neuroticism. In contrast, the genetic factors shared between indicators of depression and urge or mixed UI were entirely in common with neuroticism. In conclusion, depression and neuroticism are associated with UI among premenopausal women: the associations are in part determined by genetic factors in common to the disorders.

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“…Dietz et al 11 identified genetic factors as responsible for 50% of variability seen in bladder neck descent in 70 twin pairs aged 18-24 years. Using the Danish Twin Registry, Rohr et al 12 identified a cohort of middle-aged and elderly women who were screened for urinary incontinence with two validated questions. They identified heritability of 42% and 49% for urge incontinence in middle-aged and elderly women, respectively.…”

Section: Discussionmentioning

confidence: 99%

Incontinence and pelvic organ prolapse in parous/nulliparous pairs of identical twins

Buchsbaum

Duecy

2008

Neurourology and Urodynamics

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Genetic and environmental influences on urinary incontinence: a Danish population‐based twin study of middle‐aged and elderly women

Abstract: Genetic factors play a substantial role in the development of urge and mixed incontinence, whereas the role of genetic factors in stress incontinence is less prominent.

Cited by 48 publications

References 23 publications

Long-term follow-up of the retropubic tension-free vaginal tape procedure

Long-term follow-up of the retropubic tension-free vaginal tape procedure

Depression, Neuroticism, and Urinary Incontinence in Premenopausal Women: A Nationwide Twin Study

Incontinence and pelvic organ prolapse in parous/nulliparous pairs of identical twins

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