Genetic analysis of the linkage between chromosome 11q and atopy

Lympany, Penny; Welsh, Ken I.; Cochrane, G. M.; Kemeny, David M.; Lee, T. H.

doi:10.1111/j.1365-2222.1992.tb00134.x

Cited by 66 publications

(31 citation statements)

References 31 publications

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“…Using linkage analysis, Cookson and coworkers obtained evidence for the chromosomal localization of an atopy gene on chromosome 11q13 (Cookson et al 1989) and recently Shirakawa et al (1994b) identified the subunit of the high-affinity immunoglobulin E receptor (FCER1B) as the atopy gene. Attempts to replicate this finding by linkage analysis, however, produced two positive (Collee et al 1993;Shirakawa et al 1994a) and seven negative results (Amelung et al 1992;Hizawa et al 1992;Kawakami 1992;Lympany et al 1992;Rich et al 1992;Coleman et al 1993;Brereton et al 1994). These controversial findings might in part be the result of using model-dependent methods for linkage analysis under conditions where the mode of inheritance of atopy is unknown.…”

Section: Introductionmentioning

confidence: 60%

Linkage between atopy and the IgE high-affinity receptor gene at 11q13 in atopic dermatitis families

et al. 1998

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Atopic dermatitis is a common skin disease frequently associated with allergic disorders such as allergic rhinitis and asthma. Controversial linkage findings between atopy and markers at chromosome 11q13 led us to search chromosome 11 for genes conferring susceptibility to atopic dermatitis and atopy. Twelve families were investigated using highly polymorphic markers and a powerful model-free linkage test. Two markers gave evidence for linkage, D11S903 (P = 0.02) and FCER1B (P = 0.005). A two-point lod-score analysis between these two markers revealed significant evidence for linkage (zmax = 4.02 at (theta = 0.0). In regard to model-dependent lod-score analyses between atopic disorders and FCER1B, two-point analysis gave a lod score of z = 0.78 whereas two-locus analysis using a recessive-dominant mode of inheritance displayed a significant lod score of z = 3.55. Only 2 of 12 families showed evidence for linkage using the latter oligogenic model. In conclusion, the results of our study map the FCER1B gene in close proximity to D11S903, support the finding of Cookson et al. implicating the IgE high-affinity receptor gene (FCER1B) at 11q13, and furthermore suggest an oligogenic mode of inheritance as well as heterogeneity in the genetic susceptibility to atopy and atopic dermatitis.

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Section: Introductionmentioning

confidence: 60%

Linkage between atopy and the IgE high-affinity receptor gene at 11q13 in atopic dermatitis families

et al. 1998

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“…Chromosome 11q13 was the first region to which a putative atopy gene was localised (Cookson et al 1989) and members of the same group later identified the β-subunit of the high-affinity IgE receptor as a candidate gene for atopic diseases (Sandford et al 1993). Other groups (Adra et al 1999;Collee et al 1993;Cox et al 1998;FolsterHolst et al 1998;Hizawa et al 1998;Shirakawa et al 1994Shirakawa et al , 1996van Herwerden et al 1995) have confirmed genetic linkage to the 11q13 region, whereas other groups have not detected linkage to atopic disease (Amelung et al 1992;Brereton et al 1994;Coleman et al 1993;Deichmann et al 1999;Hizawa et al 1992;Lympany et al 1992;Rich et al 1992). We have found only weak evidence in favour of linkage for 11q13 to raised allergenspecific serum IgE levels.…”

Section: Discussionmentioning

confidence: 89%

Linkage and association to candidate regions in Swedish atopic dermatitis families

et al. 2001

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We have studied, in 406 families with at least two siblings affected with atopic dermatitis (in total 1514 individuals) from the Swedish population, linkage and association to five chromosomal regions (2q35, 5q31-33, 6p21, 11q13 and 14q11) previously implicated in atopic diseases. The region on 14q11 gave evidence for linkage to atopic dermatitis (NPL-score: 2.36, P<0.009). In the 11q13 region, there was a clear association to an intragenic marker in the beta-subunit of the high-affinity IgE receptor for raised allergen-specific serum IgE levels (P<0.009). When a quantitative variable for the severity of atopic dermatitis was studied, evidence was found in favour of linkage to the 5q31-33 region, with the highest Z-score (2.06) close to the marker D5S458 (P<0.005).

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“…Regarding the chromosome 11q some studies have confirmed the linkage of atopy and bronchial hyperresponsiveness to markers on 11q13 (Adra et al 1999;Collée et al 1993;Daniels et al 1996;van Herwerden et al 1995;Mao et al 1997;Shirakawa et al 1994a;Young et al 1992), while others have failed to find the linkage (Amelung et al 1992; Collaborative Study on the Genetics of Asthma 1997; Hizawa et al 1992;Lympany et al 1992;Malerba et al 1999;Ober et al 1998;Rich et al 1992;Wjst et al 1999;Yokouchi et al 2000). Meanwhile, the gene for the β-chain of the high-affinity receptor for IgE (FcεRIβ) has been identified as a candidate gene for this linkage between atopy and 11q13 (Sandford et al 1993), and two coding variants in exon 6 of FcεRIβ, Ile181Leu/Ile183Val and Ile181Leu, are reported to be associated with atopy in British subjects (Shirakawa et al 1994b).…”

Section: Introductionmentioning

confidence: 93%

Association between nasal allergy and a coding variant of the Fc ε RI β gene Glu237Gly in a Japanese population

et al. 2001

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The gene for the beta-chain of the high-affinity receptor for IgE (Fc epsilon RI beta) has been proposed as a candidate gene for atopy. A coding variant Glu237Gly has been studied in various populations with asthma and atopy, and the results were controversial for association of the variant with atopy/asthma. Because nasal allergy is a more common atopic disease and shows less remission than asthma, we analyzed whether the Glu237Gly variant is correlated with nasal allergy. The study enrolled 233 patients with nasal allergy and 100 control subjects. Further, three subgroups were selected: patients with perennial nasal allergy (n=149), Japanese cedar pollinosis (n=189), and allergy to multiple allergens (n=45). The allele frequency of Gly237 in the controls and patients was 0.14 and 0.20, and the frequency of Gly237-positive subjects was 0.23 and 0.356, respectively. There was a significant association between Gly237-positivity and nasal allergy, perennial nasal allergy, Japanese cedar pollinosis, and allergy to multiple allergens. Among all 333 subjects we observed a significant relationship between Gly237 and elevated levels of serum total IgE (>250 IU/ml) and very high IgE (>1000 IU/ml). Among patients positive for a specific IgE, Gly237 was significantly associated with high IgE for house dust, mite, and Japanese cedar pollen. These results suggest that the Glu237Gly variant of the Fc epsilon RI beta gene is involved in the development of nasal allergy through the process for the production of both specific and nonspecific IgE antibodies.

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Genetic analysis of the linkage between chromosome 11q and atopy

Cited by 66 publications

References 31 publications

Linkage between atopy and the IgE high-affinity receptor gene at 11q13 in atopic dermatitis families

Linkage between atopy and the IgE high-affinity receptor gene at 11q13 in atopic dermatitis families

Linkage and association to candidate regions in Swedish atopic dermatitis families

Association between nasal allergy and a coding variant of the Fc ε RI β gene Glu237Gly in a Japanese population

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