Association between nasal allergy and a coding variant of the Fc ε RI β gene Glu237Gly in a Japanese population

Abstract

The gene for the beta-chain of the high-affinity receptor for IgE (Fc epsilon RI beta) has been proposed as a candidate gene for atopy. A coding variant Glu237Gly has been studied in various populations with asthma and atopy, and the results were controversial for association of the variant with atopy/asthma. Because nasal allergy is a more common atopic disease and shows less remission than asthma, we analyzed whether the Glu237Gly variant is correlated with nasal allergy. The study enrolled 233 patients with nasal allergy and 100 control subjects. Further, three subgroups were selected: patients with perennial nasal allergy (n=149), Japanese cedar pollinosis (n=189), and allergy to multiple allergens (n=45). The allele frequency of Gly237 in the controls and patients was 0.14 and 0.20, and the frequency of Gly237-positive subjects was 0.23 and 0.356, respectively. There was a significant association between Gly237-positivity and nasal allergy, perennial nasal allergy, Japanese cedar pollinosis, and allergy to multiple allergens. Among all 333 subjects we observed a significant relationship between Gly237 and elevated levels of serum total IgE (>250 IU/ml) and very high IgE (>1000 IU/ml). Among patients positive for a specific IgE, Gly237 was significantly associated with high IgE for house dust, mite, and Japanese cedar pollen. These results suggest that the Glu237Gly variant of the Fc epsilon RI beta gene is involved in the development of nasal allergy through the process for the production of both specific and nonspecific IgE antibodies.

Polymorphisms in the FcεRIβ Promoter Region Affecting Transcription Activity: A Possible Promoter-Dependent Mechanism for Association between FcεRIβ and Atopy

“…The SNP in exon 7 of human Fc⑀RI␤, which results in the Glu237Gly polymorphism, has been implicated in atopic diseases as a predisposing genetic factor (3,4,6,7). In the present study, we found significant association between the Glu237Gly polymorphism and the expression level of Fc⑀RI on blood basophils (Fig.…”

“…Further studies have shown that two SNPs in exon 6 are often absent in certain populations, including the Japanese, whereas another SNP in exon 7, which causes an amino acid substitution, Glu237Gly, is more common (4,5). Although some reports have presented positive association between the Glu237Gly polymorphism and atopic diseases (3,4,6,7), other reports have not (8,9). In contrast, it has also been demonstrated that the amino acid variations in the ␤-chain, including the Glu237Gly mutation, does not affect the expression or function of Fc⑀RI in vitro (10,11).…”

Correlation analysis of gene polymorphisms and β-lactam allergy

“…The study of SNPs of FcεRIβ and IFNGR2 mainly focused on their relationships with allergic diseases such as asthma (Kim and Park, 2006;Sanak et al, 2007) and allergic rhinitis (Nagata et al, 2001), and was used to treat malignant tumors such as non-Hodgkin lymphoma (Purdue et al, 2007;Chen et al, 2011) and gastric cancer (Hou et al, 2007). IFNGR1 was reported to correlate with β-lactam allergy, however, the relationship between SNP of IFNGR2 and β-lactam allergy was not clear.…”

Angiotensin-converting enzyme insertion/deletion polymorphism associated with allergic rhinitis susceptibility: Evidence from 1410 subjects

“…1 Its main characteristics are defined as sneezing, rhinorrhea, nasal stuffiness and nasal itching and may be involved in an imbalance in the Th1/Th2 immune response. 2,3 Although the exact pathogenetic mechanisms of AR are still unknown, there is ample evidence suggesting that AR is a complex multifactorial disorder including both genetic and environmental factors [4][5][6][7][8] and some low-penetrant genes have been identified as potential AR susceptibility genes. [9][10][11] Among them, an important one is angiotensin converting enzyme (ACE), which contains 26 exons and 25 introns and is located on chromosome 17q23.…”