Genetic Analysis of the Cause of Endometrial Osseous Metaplasia

Parente, Raphael Câmara Medeiros; Patriarca, Marisa Teresinha; Oliveira, Marco Aurélio Pinho; Lasmar, Ricardo Bassil; Mendes, Paula; Sá, Paulo Gallo de; Cardeman, Leon; Silva, Rosane; Freitas, Vilmon de

doi:10.1097/aog.0b013e3181bd198c

Cited by 18 publications

(15 citation statements)

References 13 publications

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“…Cayuela et al and Parente et al confirmed that the bony tissue was of maternal origin, thus representing true osseous metaplasia. 9,16 On the other hand, Tulandi et al found the bony tissue to be of fetal origin. 17 Differential diagnosis of this disorder include endometrial tuberculosis, IUCD, malignant mixed mullerian tumour of endometrium and retained fetal bones after abortion.…”

Section: Discussionmentioning

confidence: 99%

Osseous metaplasia of endometrium: a rare cause of secondary infertility

Shah¹,

Kale²,

Shah³

2016

Int J Reprod Contracept Obstet Gynecol

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Section: Discussionmentioning

confidence: 99%

Osseous metaplasia of endometrium: a rare cause of secondary infertility

Shah¹,

Kale²,

Shah³

2016

Int J Reprod Contracept Obstet Gynecol

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“…Another study on genetic analysis of the cause of osseous metaplasia by Parente et al . also showed that DNA from the metaplastic tissue had the same origin as the patient .…”

Section: Discussionmentioning

confidence: 84%

Osseous metaplasia of the endometrium and successful hysteroscopic resection: A report of two cases and a review of the literature

Madaan

Suman

Sharma

et al. 2015

Asian J Endoscop Surgery

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Osseous metaplasia is a rare disorder of the endometrium that usually leads to secondary infertility and is frequently associated with recurrent abortions. Here we present two cases: one presenting with primary infertility and another presenting with oligomenorrhea. In both cases, vaginal ultrasonography showed an intrauterine structure that appeared hyperechogenic, suggesting calcification. Hysteroscopy revealed multiple white spicules of bony material in the uterine cavity. In both cases, the lesion was treated by hysteroscopic removal without complications. Histology established a diagnosis of endometrial osseous metaplasia. Thus, hysteroscopy was effective in the diagnosis and treatment of endometrial osseous metaplasia. The patient with primary infertility had spontaneous conception of twins 6 months after the procedure.

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“…However, some cases present either after very early abortion or without a history of pregnancy, suggesting a phenomenon of metaplasia of endometrial stromal cells into osteoblastic cells. This is supported by genetic sequencing which has identified identical DNA in bone fragments to that of the host, indicating that a host derivation is more likely than fetal tissue remnants 16 17. In addition, analysis of bovine endometrial stromal cells and equine placental mesenchymal stem cells has identified osteogenic properties, indicating a potential for osseous metaplasia 11 18.…”

Section: Discussionmentioning

confidence: 90%

Endometrial osseous metaplasia and endometritis in a Thoroughbred broodmare

Savage

2019

Vet Record Case Reports

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Endometrial osseous metaplasia is a condition characterised by the presence of mature bone fragments within the endometrium. It is rarely reported in human beings and other domestic mammals, but to the author’s knowledge has not previously been recognised in horses. This case describes a Thoroughbred broodmare presented for breeding evaluation 14 days postpartum. No previous reproductive abnormalities had been identified. Transrectal ultrasonography of the reproductive tract identified multifocal, well-defined, irregular hyperechoic structures with acoustic shadowing within the uterine wall. Following a single, unsuccessful, reproductive cycle, the fragments were manually removed. Histopathology identified osseous metaplasia and septic endometritis. A combination of intrauterine treatments were implemented, including lavage, infusion with both N-acetylcysteine and antibiotics. Chemical curettage was performed using an intrauterine kerosene infusion to remove the remaining microspicules and resolve the endometritis. The mare successfully conceived twin embryos. Following manual ablation of one conceptus, the remaining pregnancy was successfully carried to term.

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Genetic Analysis of the Cause of Endometrial Osseous Metaplasia

Abstract: III.

Cited by 18 publications

References 13 publications

Osseous metaplasia of endometrium: a rare cause of secondary infertility

Osseous metaplasia of endometrium: a rare cause of secondary infertility

Osseous metaplasia of the endometrium and successful hysteroscopic resection: A report of two cases and a review of the literature

Endometrial osseous metaplasia and endometritis in a Thoroughbred broodmare

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