Osseous metaplasia of endometrium: a rare cause of secondary infertility

Shah, Nitin; Kale, Kalyani G.; Shah, Vaishali

doi:10.18203/2320-1770.ijrcog20160405

Cited by 3 publications

(5 citation statements)

References 13 publications

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“…[7] It has broad range of clinical presentation varying from menstrual irregularities, pelvic pain, dyspareunia, vaginal discharge to even secondary infertility. [8] Like the present case, many of the previous published cases had reported secondary infertility [9][10][11][12] and subsequent conception with conservative treatment approach. Hysteroscopic evacuation of bony and cartilaginous tissue has always been the treatment of choice.…”

Section: Discussionsupporting

confidence: 55%

“…[11,12] But nowadays, recent studies recommend ultrasound assisted hysteroscopic removal of the bone and cartilage to aid proper visualization and thorough removal of tissue from endometrium as well as those embedded in the myometrium. [4,7,12,13] Knowing its non-neoplastic nature and a conservative approach of management, this condition needs to be recognized by pathologists to avoid making an overdiagnosis of malignant mixed mullerian tumor of the uterus . [ 7,11,13]…”

Section: Discussionmentioning

confidence: 99%

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Osseocartilaginous metaplasia in the Endometrium: A Rare Reversible Cause of Secondary Infertility

Senapati¹,

Mahawar²,

Pani³

2022

Ann of Pathol and Lab Med

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Osteo-cartilaginous metaplasia in endometrium is an infrequent finding and usually presents with secondary infertility. This is a benign entity and usually associated with a previous history of abortion. It can be treated successfully with hysteroscopy and henceforth reverting infertility. Awareness of this entity is important in order to avoid overdiagnosis of mixed Mullerian tumor of the endometrium followed by hysterectomy. Herein, we present one such case of a 28-year-old female who presented with secondary infertility.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Osseocartilaginous metaplasia in the Endometrium: A Rare Reversible Cause of Secondary Infertility

Senapati¹,

Mahawar²,

Pani³

2022

Ann of Pathol and Lab Med

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“…Ossification can also be observed at other locations including the cervix, ovary, and vagina. 2 Majority of the affected patients are in the reproductive age group, though a rare case of postmenopausal osseous metaplasia of the endometrium in a 62-year-old woman who had a history of abortion 37 years ago also has been reported by Shimizu et al 2,4 In majority of the reported cases, the osseous changes in the endometrium were followed by a previous history of abortion. Majority of the patients are in the reproductive age group with history of first trimester abortion either therapeutic or spontaneous.…”

Section: Discussionmentioning

confidence: 92%

“…3,8 The treatment for this disorder should be accomplished by hysteroscopic removal of osseous fragments to be submitted for histopathological examination, or by uterine curettage as a second choice. 2,3 In the present case, the first alternative was adopted.…”

Section: Discussionmentioning

confidence: 99%

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Osseous Endometrial Metaplasia in a Case of Primary Infertility

Shrivastava¹,

Chadha²,

Salve³

et al. 2019

International Journal of Infertility &Amp; Fetal Medicine

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Endometrial osseous metaplasia is a rare pathological condition characterized by the presence of bone-like tissue in the endometrium and can be a cause for menstrual abnormalities and infertility as bone in the endometrium can act like an intrauterine contraceptive device. It is a rare entity with an estimated incidence of 3/10,000. Exact etiopathogenesis is not known but the most accepted theory is metaplasia of stromal cells into osteoblast cells, which results in the formation of bones. The possibility of malignant mixed Mullerian tumor should also be kept in mind. Here, we report one such case of primary infertility in a 27-year-old woman presenting with history of oligomenorrhea. Endometrial stromal (osseous) metaplasia is a condition that is rarely seen and may have a potential to be overlooked and misdiagnosed. It is important to recognize the non-neoplastic nature of this condition to avoid misinterpretation as malignant mixed Mullerian tumor of the uterus. Its contraceptive nature makes it an extremely rare but treatable cause of infertility. Complete removal of bony spicules by hysteroscopy can help regain fertility.

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Hysteroscopic Retrieval of Intrauterine Retained Fetal Bones Causing Infertility in a Tertiary Teaching Hospital: A Case Series

Adewole,

Owa,

Musa

et al. 2023

Afr J Reprod Gynaecol Endosc

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Background: Retained fetal bone is a rare complication of unsafe abortion, causing infertility by functioning similarly to an intrauterine device. Clinical and radiological evaluation may be inconclusive. Hysteroscopic evaluation is the gold-standard diagnostic and therapeutic procedure associated with fertility restoration. Materials and Methods: Out of 300 hysteroscopies performed from September 22, 2015, to September 21, 2022, six cases of retained fetal bones were identified. Results: The incidence was 2.0%. The age range was 26 to 44 years. Five out of six were nulliparous, and all women had a previous history of unsafe abortion. The gestational age at the previous abortion ranged from 12 to 24 weeks. The fetal bones were completely removed in all cases. Two out of six cases (33.3%) had favourable outcomes with spontaneous conception and live births. Conclusion: Retained fetal bone is a rare cause of infertility associated with diagnostic challenges, especially in low-resource settings. However, the removal of the fetal bone with hysteroscopy can restore fertility.

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Osseous metaplasia of endometrium: a rare cause of secondary infertility

Cited by 3 publications

References 13 publications

Osseocartilaginous metaplasia in the Endometrium: A Rare Reversible Cause of Secondary Infertility

Osseocartilaginous metaplasia in the Endometrium: A Rare Reversible Cause of Secondary Infertility

Osseous Endometrial Metaplasia in a Case of Primary Infertility

Hysteroscopic Retrieval of Intrauterine Retained Fetal Bones Causing Infertility in a Tertiary Teaching Hospital: A Case Series

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