Genetic Analysis of Dilated Cardiomyopathy. HLA and immunoglobulin genes may confer susceptibility.

Allelic polymorphisms and RFLP in the human immunoglobulin lambda light chain locus

“…Several RFLP polymorphisms affecting IGLV genes (Blancher et al 1990;Chuchana et al 1990bChuchana et al , 1993Frippiat et al 1995) were also reported. Associations between IGLC or IGLV allele frequencies and susceptibility to Graves' disease, rheumatoid arthritis, silicosis or dilated cardiomyopathy have been described (Sidebottom et al 1987;Williams et al 1988;Nishi et al 1992;Honda et al 1993). There is also a preferential association between proteins of the IGLV6 subgroup and amyloidosis AL (Solomon et al 1982).…”

Autoimmune myocarditis induced in mice by cardiac C-protein. Cloning of complementary DNA encoding murine cardiac C-protein and partial characterization of the antigenic peptides.

“…However, several lines of evidence suggest that DCM is preceded by autoimmune myocarditis; autoantibodies against various cardiac proteins (5-8), abnormal expression of class II HLA-DR antigens on the myocardium, and a familial background support this notion (9)(10)(11). Although there is clear evidence that the autoantibodies of DCM patients react to several different proteins, the epitopes for experimental autoimmune myocarditis models and DCM still remain limited.…”

Human leukocyte antigen-DQ beta 1 chain (DQB1) gene polymorphisms are associated with dilated cardiomyopathy: A systematic review and meta-analysis

“…11,13 In recent years, the relationship between polymorphisms in the HLA-DQA1 and HLA-DQB1 genes and DCM has received much attention. [12][13][14][15][16][17][18][19][20][21][22][23][24] The present meta-analysis indicates that the frequencies of the HLA-DQB1 *0201 and *0504 alleles are greater in normal control subjects than in patients with DCM, suggesting that these 2 genes may confer h e a r t & l u n g 4 1 ( 2 0 1 2 ) 3 6 0 e3 6 7 protection against DCM. This result is consistent with a previous meta-analysis reporting that the HLA class II (DR and DQ) antigen was associated with DCM.…”

“…[12][13][14][15][16][17][18][19][20][21][22][23][24] Of these, 1 study was performed for cases of familial dilated cardiomyopathy (FDC), 16 and the data could not be extracted from another study. 24 In addition, 1 study 17 was awaiting classification because we could not confirm whether the patients in that study were included in another similar study performed by the same first author.…”

“…[8][9][10][11][12][13] The HLA class II genes, especially the HLA-DQ alleles (including HLA-DQ beta 1 chain [DQB1]), are highly polymorphic and may play an important role in the activation of immune responses, thereby potentially affecting an individual's predisposition to DCM. [12][13][14][15][16][17][18][19][20][21][22][23][24] However, the results of these studies have been inconsistent. In addition, because of the small number of samples in most of the relevant case-control studies, the statistical power of these previous results has been limited.…”