Genetic analysis of common carp (Cyprinus carpio) strains. II: Resistance to koi herpesvirus and Aeromonas hydrophila and their relationship with pond survival

Ødegård, Jørgen; Olesen, Ingrid; Dixon, Peter; Jeney, Zsigmond; Nielsen, Henrik Skov; Way, K.; Joiner, C.; Jeney, Galina; Ardó, László; Rónyai, András; Gjerde, Bjarne

doi:10.1016/j.aquaculture.2010.03.017

Cited by 65 publications

(49 citation statements)

References 15 publications

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“…Shapira et al (2005) reported that crossing the domesticated carp and Našice (introduced in Israel from ex-Yugoslavia in the 1970s) with a wild carp strain Sassan (originated from the Amur river) significantly increases the resistance to CyHV-3 (Shapira et al, 2005). Carp genetic resistance to CyHV-3 has also been investigated using 96 carp families derived from diallelic crossbreeding of two wild carp strains (Amur and Duna, native of the Amur and Danube rivers) and two domesticated Hungarian strains (Tat, and Szarvas 15) (Dixon et al, 2009;Ødegård et al, 2010). These studies showed that overall the more resistant families derived from wild-type strains, even if important variations were observed according to the pair of genitors used (Dixon et al, 2009).…”

Section: Susceptibility Of Common Carp According To Host Genetic Backmentioning

confidence: 99%

Cyprinid Herpesvirus 3

Boutier

Ronsmans

Rakus

et al. 2015

Advances in Virus Research

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Section: Susceptibility Of Common Carp According To Host Genetic Backmentioning

confidence: 99%

Cyprinid Herpesvirus 3

Boutier

Ronsmans

Rakus

et al. 2015

Advances in Virus Research

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“…The higher virus load seen in the internal tissues of carp from this breeding line could be one of the factors responsible for mortality. It has been shown that in the kidney a CyHV-3 infection leads to the degradation of distal tubules (Hedrick et al 2000, Pikarsky et al 2004), which causes a massive deterioration of the electrolyte balance (Negenborn 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Genetic differences in the resistance of different carp breeding lines and crossbreeds to CyHV-3-induced disease have also been reported (Shapira et al 2005, Rakus et al 2009, Odegard et al 2010, Pia<ková et al 2013; however, very little is known about the genetic factors which could be associated with these differences (Adamek et al 2014). Recently, we analysed the immune response of 2 genetic carp lines with different susceptibility to KHVD in a transcriptome study based on DNA microarray and real time quantitative PCR (RT-qPCR) analyses, whereby we demonstrated that the differences in the resistance to KHVD between the carp lines can be correlated with differences in expression of immune-related genes .…”

Section: Introductionmentioning

confidence: 99%

Interaction between type I interferon and Cyprinid herpesvirus 3 in two genetic lines of common carp Cyprinus carpio

Adamek¹,

Rakus²,

Brogden³

et al. 2014

Dis. Aquat. Org.

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Cyprinid herpesvirus 3 (CyHV-3) infection in common carp Cyprinus carpio L. and its ornamental koi varieties can induce the severe systemic disease known as koi herpesvirus disease. This disease is characterised by a rapid replication and spreading of the virus through multiple organs and results in a fast onset of mortality (starting on Day 6 post infection) in up to 100% of infected fish. During the first phase of viral infections, type I interferons (IFNs) have generally been proven to be essential in inducing an innate immune response; however, very little is known about the type I IFN response to herpesviruses in fish. The aim of this work was to study the type I IFN responses during CyHV-3 infection in 2 genetically divergent lines of common carp which presented differing survival rates. Our results show that CyHV-3 induced a systemic type I IFN response in carp, and the magnitude of type I IFN expression is correlated with the virus load found in skin and head kidney. In this in vivo experimental setup, the level of type I IFN response cannot be linked with higher survival of carp during CyHV-3 infection.

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“…Thus, enhancing fish resistance against diseases through selective breeding is necessary. Resistance to A. hydrophila in fish is known to be heritable, with heritability estimates ranging from 0.03-0.39 (Mahapatra et al, 2008;Ødegård et al, 2010). Differences in susceptibility have also been observed among different individual fish (Mahapatra et al, 2008;Crumlish et al, 2010).…”

Section: Introductionmentioning

confidence: 95%

A 425 T>C polymorphism in complement C7 association with resistance to Aeromonas hydrophila in grass carp

Shen

Zhang

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Aeromonas hydrophila, a widespread bacterium in the aquatic environment, causes hemorrhagic septicemia in fish. In the last decade, the disease has caused mass mortalities and tremendous economic loss in cultured fish. The complement component C7 is a terminal component of complement that interacts in a sequence of polymerization reactions with other terminal complement components to form a membrane attack complex. The formation of the membrane attack complex creates a pore in the membranes of certain pathogen that can lead to their death. The objective of this study was to identify single nucleotide polymorphisms (SNPs) in the C7 gene and to assess their association with A. hydrophila resistance in grass carp. A resource population consisting of 186 susceptible and 191 resistant grass carp was constructed. We sequenced a total of 7826 bp of the C7 gene and identified 6 SNPs that were genotyped in the resource population. The SNP -1575 A>C was positioned in the promoter region of the gene. The SNP 425 C>T identified in the coding exon was a synonymous substitution in the fourth exon. Statistical analysis showed that SNP 425 C>T was associated with the incidence of hemorrhagic septicemia. The SNPs -1575 A>C, -688 T>C, and -266 A>C were highly linked together (r 2 > 0.85). No haplotypes generated with these 3 SNPs were associated with resistance to A. hydrophila in grass carp. These findings suggest that the 425 C>T polymorphism in C7 gene may be a significant molecular marker for resistance to A. hydrophila in grass carp.

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Genetic analysis of common carp (Cyprinus carpio) strains. II: Resistance to koi herpesvirus and Aeromonas hydrophila and their relationship with pond survival

Cited by 65 publications

References 15 publications

Cyprinid Herpesvirus 3

Cyprinid Herpesvirus 3

Interaction between type I interferon and Cyprinid herpesvirus 3 in two genetic lines of common carp Cyprinus carpio

A 425 T>C polymorphism in complement C7 association with resistance to Aeromonas hydrophila in grass carp

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