Genetic analysis of canine parvovirus type 2c

Decaro, Nicola; Desario, Costantina; Parisi, Antonio; Martella, Vito; Lorusso, Alessio; Miccolupo, Angela; Mari, Viviana; Colaianni, Maria Loredana; Cavalli, Alessandra; Trani, Livia Di; Buonavoglia, Canio

doi:10.1016/j.virol.2008.12.016

Cited by 114 publications

(129 citation statements)

References 19 publications

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“…In accordance with Pinto et al (2012), the amino acid substitution Thr440Ala was not observed in any CPV-2c sequences, as previously described in CPV-2a and CPV-2b strains from Italy (Battilani et al 2002), India (Chinchkar et al 2006), Korea (Kang et al 2008), and in CPV-2c strains from Argentina (Calderón et al 2011) and Italy (Decaro et al 2009). The 440 position is located at an important VP2 domain, undergoing positive selection and envolved independently in different populations ).…”

Section: Discussionsupporting

confidence: 85%

A phylogenetic study of canine parvovirus type 2c in midwestern Brazil

et al. 2013

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Section: Discussionsupporting

confidence: 85%

A phylogenetic study of canine parvovirus type 2c in midwestern Brazil

et al. 2013

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“…Only one CPV VP2 sequence from Lithuania (LTU31CPV2) was associated with CPV-2b VP2 sequences from France, Italy, USA and Korea (cluster 6). As it was expected and reported previously (Decaro et al 2009) all the CPV-2c VP2 sequences formed a monophyletic cluster (cluster 7). Despite the strong phylogenetic association with CPV-2a ancestor, the Lithuanian CPV VP2 sequences show more or less geographically defined evolution pattern (especially five CPV samples in the first cluster), as were identified in other regions and studies (Battilani et al 2002, Wang et al 2005, Kang et al 2008.…”

Section: Discussionsupporting

confidence: 88%

Phylogenetic characterization of Canine Parvovirus VP2 partial sequences from symptomatic dogs samples

Zienius¹,

Lelešius²,

Kavaliauskis³

et al. 2016

Polish Journal of Veterinary Sciences

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The aim of the present study was to detect canine parvovirus (CPV) from faecal samples of clinically ill domestic dogs by polymerase chain reaction (PCR) followed by VP2 gene partial sequencing and molecular characterization of circulating strains in Lithuania.Eleven clinically and antigen-tested positive dog faecal samples, collected during the period of 2014-2015, were investigated by using PCR. The phylogenetic investigations indicated that the Lithuanian CPV VP2 partial sequences (3025-3706 cds) were closely related and showed 99.0-99.9% identity. All Lithuanian sequences were associated with one phylogroup, but grouped in different clusters. Ten of investigated Lithuanian CPV VP2 sequences were closely associated with CPV 2a antigenic variant (99.4% nt identity). Five CPV VP2 sequences from Lithuania were related to CPV-2a, but were rather divergent (6.8 nt differences). Only one CPV VP2 sequence from Lithuania was associated (99.3% nt identity) with CPV-2b VP2 sequences from France, Italy, USA and Korea. The four of eleven investigated Lithuanian dogs with CPV infection symptoms were vaccinated with CPV-2 vaccine, but their VP2 sequences were phylogenetically distantly associated with CPV vaccine strains VP2 sequences (11.5-15.8 nt differences).Ten Lithuanian CPV VP2 sequences had monophyletic relations among the close geographically associated samples, but five of them were rather divergent (1.0% less sequence similarity). The one Lithuanian CPV VP2 sequence was closely related with CPV-2b antigenic variant. All the Lithuanian CPV VP2 partial sequences were conservative and phylogenetically low associated with most commonly used CPV vaccine strains.

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“…At present, CPV-2c is broadly distributed in Italy (16), and has also been found in Spain (8), Germany, the United Kingdom (9), the United States (13), Australia (17), and Portugal (27). Although the first reports seemed to show a low pathogenicity for CPV-2c, experimental data and field observations now indicate that a more severe clinical course with higher mortality rates is associated with CPV-2c infection (10).…”

Section: Introductionmentioning

confidence: 99%