Genetic analysis of an overlapping functional requirement for L1- and NCAM-type proteins during sensory axon guidance in Drosophila

Kristiansen, Lars V.; Velasquez, Emma; Romani, Susana; Baars, Sigrid; Berezin, Vladimir; Bock, Elisabeth; Hortsch, Michael; García‐Alonso, Luis

doi:10.1016/j.mcn.2004.09.003

Cited by 41 publications

(66 citation statements)

References 62 publications

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“…The initial activation of the EGF receptor could be initiated in a ligand-independent manner. The broadly expressed adhesion protein Neuroglian is not only a core component of septate junctions but is also known to activate receptor tyrosine kinase signaling in a ligand-independent manner (Doherty and Walsh, 1996;Donier et al, 2012;García-Alonso et al, 2000;Gibson and Tolbert, 2006;Gibson et al, 2012;Islam et al, 2004;Kristiansen et al, 2005;Nagaraj et al, 2009). Possibly, Neuroglian might thus deliver a first trigger signal to initiate glial differentiation, independent of activating ligands such as Vein or Spitz.…”

Section: Discussionmentioning

confidence: 99%

Axonal wrapping in theDrosophilaPNS is controlled by glia-derived neuregulin homolog Vein

et al. 2015

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Efficient neuronal conductance requires that axons are insulated by glial cells. For this, glial membranes need to wrap around axons. Invertebrates show a relatively simple extension of glial membranes around the axons, resembling Remak fibers formed by Schwann cells in the mammalian peripheral nervous system. To unravel the molecular pathways underlying differentiation of glial cells that provide axonal wrapping, we are using the genetically amenable Drosophila model. At the end of larval life, the wrapping glia differentiates into very large cells, spanning more than 1 mm of axonal length. The extension around axonal membranes is not influenced by the caliber of the axon or its modality. Using cell typespecific gene knockdown we show that the extension of glial membranes around the axons is regulated by an autocrine activation of the EGF receptor through the neuregulin homolog Vein. This resembles the molecular mechanism employed during cell-autonomous reactivation of glial differentiation after injury in mammals. We further demonstrate that Vein, produced by the wrapping glia, also regulates the formation of septate junctions in the abutting subperineurial glia. Moreover, the wrapping glia indirectly controls the proliferation of the perineurial glia. Thus, the wrapping glia appears center stage to orchestrate the development of the different glial cell layers in a peripheral nerve.

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Section: Discussionmentioning

confidence: 99%

Axonal wrapping in theDrosophilaPNS is controlled by glia-derived neuregulin homolog Vein

et al. 2015

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“…FGFRs and EGFRs in both vertebrates and in Drosophila have been shown to be activated via homophilic and heterophilic interactions in cis and in trans between the IgCAMs L1/Neuroglian, NCAM/Fasciclin II, and N-cadherin [19]–[23], [38], [39], [81], [82]. We know from our previous work [17], [18] that the transmembrane form of Manduca Fasciclin II (TM-Fas II) is expressed by ORN axons and Neuroglian is expressed by ORN axons and central glia.…”

Section: Discussionmentioning

confidence: 99%

Activation of Glial FGFRs Is Essential in Glial Migration, Proliferation, and Survival and in Glia-Neuron Signaling during Olfactory System Development

Gibson

Tolbert²,

Oland³

2012

PLoS ONE

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Development of the adult olfactory system of the moth Manduca sexta depends on reciprocal interactions between olfactory receptor neuron (ORN) axons growing in from the periphery and centrally-derived glial cells. Early-arriving ORN axons induce a subset of glial cells to proliferate and migrate to form an axon-sorting zone, in which later-arriving ORN axons will change their axonal neighbors and change their direction of outgrowth in order to travel with like axons to their target areas in the olfactory (antennal) lobe. These newly fasciculated axon bundles will terminate in protoglomeruli, the formation of which induces other glial cells to migrate to surround them. Glial cells do not migrate unless ORN axons are present, axons fail to fasciculate and target correctly without sufficient glial cells, and protoglomeruli are not maintained without a glial surround. We have shown previously that Epidermal Growth Factor receptors and the IgCAMs Neuroglian and Fasciclin II play a role in the ORN responses to glial cells. In the present work, we present evidence for the importance of glial Fibroblast Growth Factor receptors in glial migration, proliferation, and survival in this developing pathway. We also report changes in growth patterns of ORN axons and of the dendrites of olfactory (antennal lobe) neurons following blockade of glial FGFR activation that suggest that glial FGFR activation is important in reciprocal communication between neurons and glial cells.

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“…Neuronal expression of Nrg rescues the mutant phenotype suggesting that Nrg mediates heterophilic adhesion of the advancing axons with their substrate (Martin et al 2008). In the adult ocellar sensory system, Nrg establishes two distinct axonal pathways, one originating from the bristle mechanoreceptors and the other originating from the ocellar pioneer neurons (Garcia-Alonso et al 2000;Kristiansen et al 2005). Especially in the ocellar pioneer neurons, Nrg functions redundantly with Fas II.…”

Section: L1-cammentioning

confidence: 99%

Cell Adhesion, the Backbone of the Synapse: "Vertebrate" and "Invertebrate" Perspectives

Γιαγτζόγλου¹,

Ly²,

Bellen³

2009

Cold Spring Harbor Perspectives in Biology

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Genetic analysis of an overlapping functional requirement for L1- and NCAM-type proteins during sensory axon guidance in Drosophila

Cited by 41 publications

References 62 publications

Axonal wrapping in theDrosophilaPNS is controlled by glia-derived neuregulin homolog Vein

Axonal wrapping in theDrosophilaPNS is controlled by glia-derived neuregulin homolog Vein

Activation of Glial FGFRs Is Essential in Glial Migration, Proliferation, and Survival and in Glia-Neuron Signaling during Olfactory System Development

Cell Adhesion, the Backbone of the Synapse: "Vertebrate" and "Invertebrate" Perspectives

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