Genetic affinity and admixture of northern Thai people along their migration route in northern Thailand: evidence from autosomal STR loci

Kutanan, Wibhu; Kampuansai, Jatupol; Colonna, Vincenza; Nakbunlung, Supaporn; Lertvicha, Pornpilai; Seielstad, Mark; Bertorelle, Giorgio; Kangwanpong, Daoroong

doi:10.1038/jhg.2010.135

Cited by 20 publications

(27 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The DNA samples were obtained from our previous studies with written informed consent [21,23]. We genotyped a total of 104 binary polymorphisms on the Y chromosome (M6, M49, M32, M42, M94, P85, M181, M182, M168, M294, P144, M174, M15, M179, P99, M96, P150, P147, M75, P143, M216, RPS4Y711, M8, M105, M38, M217, M356, P55, M428, P96, M201, P257, M342, P287, M69, M52, P127, P123, M258, U179, M253, M450, P215, P209, M304, M172, M9, P128, M147, P60, P79, P261, P263, M11, M20, M76, M317, M357, P256, M106, M5, M353, P118, P195, M214, M231, P191, P186, M119, P31, M122, P198, M45, P281, M242, M306, M173, P231, M124, P249, P204, P202, M70, M320, M128, P63, Tat, P203, M103, M50, M95, PK4, M111, M88, SRY465, P49, 47z, M324, M121, M164, M159, M7, M134 and M117) according to iPLEX Assay [24] using a Sequenom Mass ARRAY iPLEX Platform (Sequenom, Hamburg, Germany).…”

Section: Methodsmentioning

confidence: 99%

“…We first constructed two competing models (Fig 1), which are admixture and tree-like models based on our previous results [21,22]. …”

Section: Methodsmentioning

confidence: 99%

“…A previous study, based on comparisons among autosomal Short Tandem Repeat (STR) loci, suggested an admixed origin for KM, with a higher contribution from the TK than from the MK groups [21]. On the other hand, a coalescent modelling using mtDNA genome data indicated southern China as the most probable origin of the KM, without admixture with LW groups in northern Thailand [22].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Y chromosomal evidence on the origin of northern Thai people

et al. 2017

Self Cite

View full text Add to dashboard Cite

The Khon Mueang represent the major group of people present in today's northern Thailand. While linguistic and genetic data seem to support a shared ancestry between Khon Mueang and other Tai-Kadai speaking people, the possibility of an admixed origin with contribution from local Mon-Khmer population could not be ruled out. Previous studies conducted on northern Thai people did not provide a definitive answer and, in addition, have largely overlooked the distribution of paternal lineages in the area. In this work we aim to provide a comprehensive analysis of Y paternal lineages in northern Thailand and to explicitly model the origin of the Khon Mueang population. We obtained and analysed new Y chromosomal haplogroup data from more than 500 northern Thai individuals including Khon Mueang, Mon-Khmer and Tai-Kadai. We also explicitly simulated different demographic scenarios, developed to explain the Khon Mueang origin, employing an ABC simulation framework on both mitochondrial and Y microsatellites data. Our results highlighted a similar haplogroup composition of Khon Mueang and Tai-Kadai populations in northern Thailand, with shared high frequencies of haplogroups O-PK4, O-M117 and O-M111. Our ABC simulations also favoured a model in which the ancestors of modern Khon Mueang originated recently after a split from the other Tai-Kadai populations. Our different analyses concluded that the ancestors of Khon Mueang are likely to have originated from the same source of the other Tai-Kadai groups in southern China, with subsequent admixture events involving native Mon-Khmer speakers restricted to some specific populations.

show abstract

Section: Methodsmentioning

confidence: 99%

“…We first constructed two competing models (Fig 1), which are admixture and tree-like models based on our previous results [21,22]. …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Y chromosomal evidence on the origin of northern Thai people

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Over the past few decades, the US‐combined DNA index system (CODIS) containing 13 autosomal microsatellites or STRs has been developed as a popular genetic marker broadly used for forensic biology and population genetics due to its hypervariability and ubiquity throughout the human genome (Budowle et al., ; Ellegren, ; Budowle & Chakraborty, ; Rosenberg et al., ; Jobling and Gill, ; Butler, , ). This set of markers has been utilized to infer human population history and relationships among continental populations (Silva et al., ) as well as between geographically contiguous populations (Kutanan et al., , ; Kutanan & Kampuansai, ).…”

Section: Introductionmentioning

confidence: 99%

Admixed Origin of the Kayah (Red Karen) in Northern Thailand Revealed by Biparental and Paternal Markers

Kutanan

Srikummool

Pittayaporn

et al. 2015

Annals of Human Genetics

Self Cite

View full text Add to dashboard Cite

SummaryThis study analyzes the autosomal short tandem repeats (STRs) variation and the presence of Y chromosomal haplogroups from 44 individuals of the Kayah or Red Karen (KA) in Northern Thailand. The results based on autosomal STRs indicated that the KA exhibited closer genetic relatedness to populations from adjacent regions in Southeast Asia (SEA) than populations from Northeast Asia (NEA) and Tibet. Moreover, an admixed origin of the KA forming three population groups was observed: NEA, Southern China, and Northern Thailand. The NEA populations made a minor genetic contribution to the KA, while the rest came from populations speaking Sino-Tibetan (ST) languages from Southern China and Tai-Kadai (TK) speaking groups from Northern Thailand. The presence of six paternal haplogroups, composed of dual haplogroups prevalent in NEA (NO, N, and D1) and SEA (O2 and O3) as well as the intermediate genetic position of the KA between the SEA and NEA also indicated an admixed origin of male KA lineages. Our genetic results thus agree with findings in linguistics that Karenic languages are ST languages that became heavily influenced by TK during their southward spread. A result of the Mongol invasions during the 13 th century A.D. is one possible explanation for genetic contribution of NEA to the KA.

show abstract

“…Previous studies of human genetic diversity in Thailand were done with limited marker sets [22,23], and/or limited sampling (restricted to ethnic minorities); [2,22,24-28]. To better our understanding of mainland Southeast Asian and Thai population genetics, we undertook a study of Thai population genetic structure.…”

Section: Introductionmentioning

confidence: 99%

Insight into the Peopling of Mainland Southeast Asia from Thai Population Genetic Structure

et al. 2013

View full text Add to dashboard Cite

There is considerable ethno-linguistic and genetic variation among human populations in Asia, although tracing the origins of this diversity is complicated by migration events. Thailand is at the center of Mainland Southeast Asia (MSEA), a region within Asia that has not been extensively studied. Genetic substructure may exist in the Thai population, since waves of migration from southern China throughout its recent history may have contributed to substantial gene flow. Autosomal SNP data were collated for 438,503 markers from 992 Thai individuals. Using the available self-reported regional origin, four Thai subpopulations genetically distinct from each other and from other Asian populations were resolved by Neighbor-Joining analysis using a 41,569 marker subset. Using an independent Principal Components-based unsupervised clustering approach, four major MSEA subpopulations were resolved in which regional bias was apparent. A major ancestry component was common to these MSEA subpopulations and distinguishes them from other Asian subpopulations. On the other hand, these MSEA subpopulations were admixed with other ancestries, in particular one shared with Chinese. Subpopulation clustering using only Thai individuals and the complete marker set resolved four subpopulations, which are distributed differently across Thailand. A Sino-Thai subpopulation was concentrated in the Central region of Thailand, although this constituted a minority in an otherwise diverse region. Among the most highly differentiated markers which distinguish the Thai subpopulations, several map to regions known to affect phenotypic traits such as skin pigmentation and susceptibility to common diseases. The subpopulation patterns elucidated have important implications for evolutionary and medical genetics. The subpopulation structure within Thailand may reflect the contributions of different migrants throughout the history of MSEA. The information will also be important for genetic association studies to account for population-structure confounding effects.

show abstract

Genetic affinity and admixture of northern Thai people along their migration route in northern Thailand: evidence from autosomal STR loci

Cited by 20 publications

References 34 publications

Y chromosomal evidence on the origin of northern Thai people

Y chromosomal evidence on the origin of northern Thai people

Admixed Origin of the Kayah (Red Karen) in Northern Thailand Revealed by Biparental and Paternal Markers

Insight into the Peopling of Mainland Southeast Asia from Thai Population Genetic Structure

Contact Info

Product

Resources

About