Genetic admixture and diversity estimations in the Mexican Mestizo population from Mexico City using 15 STR polymorphic markers

Juárez‐Cedillo, Teresa; Zúñiga, Joaquı́n; Acuña-Alonzo, Víctor; Pérez-Hernández, Nonanzit; Rodrı́guez-Pérez, José Manuel; Barquera, Rodrigo; Gallardo, Guillermo J.; Sánchez-Arenas, Rosalinda; García-Peña, Maria del Carmen; Granados, Julio; Vargas‐Alarcón, Gilberto

doi:10.1016/j.fsigen.2007.08.017

Cited by 70 publications

(44 citation statements)

References 15 publications

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“…Additionally, the predominant European male contribution has been also described in earlier analyses using Y chromosome markers (Builes et al 2007). The European ancestry proportion estimated in this group is lower than those described in studies of Latin American populations as Mexicans, Afro-Brazilians, Venezuelan, Costa Rican, and Colombians (Bedoya et al 2006;Bonilla et al 2004a, b;Carvajal-Carmona et al 2000;Martinez-Marignac et al 2007;Martinez et al 2007b;Morera et al 2003;Muniz et al 2008;Salari et al 2005;Shriver et al 2003), but higher than those in Mexican mestizos from Mexico city and African Americans (Juarez-Cedillo et al 2008;Parra et al 1998;Shriver et al 2003). On the contrary, the African ancestry in this population located in the Caribbean Coast of Colombia is lower than those described in other African Caribbean (Benn-Torres et al 2008;Miljkovic-Gacic et al 2005), and African American populations ) but higher than those described in urban Afro-Brazilian, Venezuelan and Costa Rican populations (Martinez et al 2007b;Morera et al 2003;Muniz et al 2008).…”

Section: Discussionmentioning

confidence: 55%

African ancestry is associated with risk of asthma and high total serum IgE in a population from the Caribbean Coast of Colombia

et al. 2009

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African descended populations exhibit an increased prevalence of asthma and allergies compared to Europeans. One approach to distinguish between environmental and genetic explanations for this difference is to study relationships of asthma risk to individual admixture. We aimed to determine the admixture proportions of a case-control sample from the Caribbean Coast of Colombia currently participating in genetic studies for asthma, and to test for population stratification and association between African ancestry and asthma and total serum IgE levels (tIgE). We genotyped 368 asthmatics and 365 non-asthmatics for 52 autosomal ancestry informative markers, six mtDNA haplogroups and nine haplogroups and five microsatellites in Y chromosome. Autosomal admixture proportions, population stratification, and associations between ancestry and the phenotypes were estimated by ADMIXMAP. The average admixture proportions among asthmatics were 42.8% European, 39.9% African and 17.2% Native American and among non-asthmatics they were 44.2% (P = 0.068), 37.6% (P = 0.007) and 18.1% (P = 0.050), respectively. In the total sample, the paternal contributions were 71% European, 25% African and 4.0% Native American and the maternal lineages were 56.8% Native American, and 20.2% African; 22.9% of the individuals carried other non-Native American mtDNA haplogroups. African ancestry was significantly associated with asthma (OR: 2.97; 95% CI: 1.08-8.08), high tIgE (OR: 1.9; 95% CI: 1.17-3.12) and socioeconomic status (OR = 0.64; 95% CI: 0.47-0.87). Significant population stratification was observed in this sample. Our findings indicate that genetic factors can explain the association between asthma and African ancestry and suggest that this sample is a useful resource for performing admixture mapping for asthma.

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Section: Discussionmentioning

confidence: 55%

African ancestry is associated with risk of asthma and high total serum IgE in a population from the Caribbean Coast of Colombia

et al. 2009

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“…To determine whether an individual has alopecia, the normal density of the follicular units must be considered with regard to our Mexican mestizo characteristics, based on our unique genetic mixture – estimated as comprising 69% native Amerindian genes, 26% Caucasian, and 5% African [11-13]. …”

Section: Discussionmentioning

confidence: 99%

Quantification of Hair Follicles in the Scalp in Mexican Mestizo Population

Martínez-Luna

Rodríguez-Lobato

Vázquez-Velo³

et al. 2018

Skin Appendage Disord

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Introduction: There are no reports of the density of hair follicles in the scalp of Mexican mestizo population, necessitating the determination of normal references values for this population compared with other ethnic groups. Objective: To determine the average hair follicle count on the scalp in Mexican mestizo population. Materials and Methods: A total of 50 scalp samples (25 men and 25 women) from Mexican mestizo individuals aged between 19 and 60 years, with no clinical evidence of hair disease, obtained by biopsy punch at General Hospital “Dr. Manuel Gea González” were collected over 2 years. The total follicular density, vellus and terminal hair follicles, and the percentage in anagen and catagen-telogen phase were measured. χ² was used as the basic statistical test. Results: The mean number of total hair follicles in our Mexican mestizo population was 23.2 ± 4.2, which is lower compared with Thais, Iranians, and Caucasians. However, the ratio of terminal and vellus hair follicles was higher than in Thais, Caucasians, and African-Americans. The percentage of terminal hairs in anagen phase was lower than in the other populations, and higher in telogen, without exceeding 15%, established as the normal reference value. There was an association between sex and terminal hairs in telogen phase (p < 0.05). The average follicular density per mm² was slightly higher compared with African-Americans and Asians. Women had more terminal hairs than men. Conclusions: The density of total follicles is lower in the Mexican mestizo population compared with Iranians, Thais, and Caucasians. However, the greater number of terminal hairs compared to vellus hairs gives the appearance of greater overall volume. The results of this study can be used as a reference for diseases of the scalp in the Mexican population.

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“…6,11,21,23,[25][26][27][28][29][30] The admixture estimates reported in these studies are based on blood groups, serum proteins, STRs and AIMs. As a whole, the data are consistent with the Mexican population history and reflect a gradient with a higher proportion of Native American ancestry in the southern states and increased ancestry of the African contribution in the states of the Gulf of Mexico.…”

Section: Discussionmentioning

confidence: 99%

Ancestry informative markers and admixture proportions in northeastern Mexico

et al. 2009

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To investigate the ancestral admixture in the Mestizo population in northeastern Mexico, we genotyped 74 ancestral informative markers (AIMs) and 15 Y-single-nucleotide polymorphisms (Y-SNPs) in 100 individuals. The Native American contribution is 56% (range: 27.4-81.2%), the European contribution is 38% (range: 16.7-70.5%) and the West African contribution is 6%. The results show a higher European contribution than was reported in other similar studies in the country, albeit with a predominant Native American ancestry. No remarkable differences in the ancestry proportions were observed using subgroups of 74, 54, 34 and 24 AIMs. The paternal lineage calculated by genotyping of 15 Y-SNPs, shows a major component of European and Eurasian ancestry markers (B78%), compared with Amerindian (B12%) and African markers (10%). This information will set a reference for future determinations of admixture proportions in the Mestizo population from Mexico and for populationbased association studies of complex diseases.

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Genetic admixture and diversity estimations in the Mexican Mestizo population from Mexico City using 15 STR polymorphic markers

Cited by 70 publications

References 15 publications

African ancestry is associated with risk of asthma and high total serum IgE in a population from the Caribbean Coast of Colombia

African ancestry is associated with risk of asthma and high total serum IgE in a population from the Caribbean Coast of Colombia

Quantification of Hair Follicles in the Scalp in Mexican Mestizo Population

Ancestry informative markers and admixture proportions in northeastern Mexico

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