Genetic aberrations of the K-ras proto-oncogene in bladder cancer in relation to pesticide exposure

Hameed, Diaa A.; Yassa, Heba A.; Agban, Michael N.; Hanna, Randa T.; Elderwy, Ahmed M.; Zwaita, Mohamed A.

doi:10.1007/s11356-018-1840-6

Cited by 10 publications

(7 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is important to note that pesticides have also been implicated in bladder tumorigenesis ( 347 , 348 ) through oxidative stress and KRAS mutation in Egyptian occupationally-exposed individuals ( 347 ).…”

Section: Resultsmentioning

confidence: 99%

A Review of Cancer Genetics and Genomics Studies in Africa

Rotimi

Salhia

2021

Front. Oncol.

View full text Add to dashboard Cite

Cancer is the second leading cause of death globally and is projected to overtake infectious disease as the leading cause of mortality in Africa within the next two decades. Cancer is a group of genomic diseases that presents with intra- and inter-population unique phenotypes, with Black populations having the burden of morbidity and mortality for most types. At large, the prevention and treatment of cancers have been propelled by the understanding of the genetic make-up of the disease of mostly non-African populations. By the same token, there is a wide knowledge gap in understanding the underlying genetic causes of, and genomic alterations associated with, cancer among black Africans. Accordingly, we performed a review of the literature to survey existing studies on cancer genetics/genomics and curated findings pertaining to publications across multiple cancer types conducted on African populations. We used PubMed MeSH terms to retrieve the relevant publications from 1990 to December 2019. The metadata of these publications were extracted using R text mining packages: RISmed and Pubmed.mineR. The data showed that only 0.329% of cancer publications globally were on Africa, and only 0.016% were on cancer genetics/genomics from Africa. Although the most prevalent cancers in Africa are cancers of the breast, cervix, uterus, and prostate, publications representing breast, colorectal, liver, and blood cancers were the most frequent in our review. The most frequently reported cancer genes were BRCA1, BRCA2, and TP53. Next, the genes reported in the reviewed publications’ abstracts were extracted and annotated into three gene ontology classes. Genes in the cellular component class were mostly associated with cell part and organelle part, while those in biological process and molecular function classes were mainly associated with cell process, biological regulation, and binding, and catalytic activity, respectively. Overall, this review highlights the paucity of research on cancer genomics on African populations, identified gaps, and discussed the need for concerted efforts to encourage more research on cancer genomics in Africa.

show abstract

Section: Resultsmentioning

confidence: 99%

A Review of Cancer Genetics and Genomics Studies in Africa

Rotimi

Salhia

2021

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…With regard to BCL2, it has been widely demonstrated that the exposure to pesticides can cause breaks and translocations of this gene, mainly represented by the t(14;18) translocation, predisposing the development of lymphomas [37]. In the same manner, pesticide exposure can induce different genetic damages, affecting the KRAS gene associated with an increased risk of bladder cancer [54].…”

Section: Discussionmentioning

confidence: 99%

Genetic and Epigenetic Alterations Induced by Pesticide Exposure: Integrated Analysis of Gene Expression, microRNA Expression, and DNA Methylation Datasets

Giambò

Leone

Gattuso

et al. 2021

IJERPH

View full text Add to dashboard Cite

Environmental or occupational exposure to pesticides is considered one of the main risk factors for the development of various diseases. Behind the development of pesticide-associated pathologies, there are both genetic and epigenetic alterations, where these latter are mainly represented by the alteration in the expression levels of microRNAs and by the change in the methylation status of the DNA. At present, no studies have comprehensively evaluated the genetic and epigenetic alterations induced by pesticides; therefore, the aim of the present study was to identify modifications in gene miRNA expression and DNA methylation useful for the prediction of pesticide exposure. For this purpose, an integrated analysis of gene expression, microRNA expression, and DNA methylation datasets obtained from the GEO DataSets database was performed to identify putative genes, microRNAs, and DNA methylation hotspots associated with pesticide exposure and responsible for the development of different diseases. In addition, DIANA-miRPath, STRING, and GO Panther prediction tools were used to establish the functional role of the putative biomarkers identified. The results obtained demonstrated that pesticides can modulate the expression levels of different genes and induce different epigenetic alterations in the expression levels of miRNAs and in the modulation of DNA methylation status.

show abstract

“…Since DNA methylation represents a molecular mechanism related to gene inhibition, it is believed that methylation in cancer may promote tumor phenotype by inhibiting genes that are initially active in the source tissues, especially those related to tumor suppressor factors, such as Rb, P53 etc [23,24]. On the other hand, the other hypomethylation sites are potentially associated with oncogene-directed methylation-associated gene-repression pathways, taking Myc, Ras and Src as examples [25][26][27]. A study by Irizarry etc show that most methylation alterations in colorectal cancer occur in 'CpG island shores', with hypermethylation enriched closer to the associated CpG islands [28].…”

Section: Discussionmentioning

confidence: 99%

A 16-CpG-based Prognostic Signature for Colorectal Cancer

Chen

Wang

Zhang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: To develop a CpG-based prognostic prediction model to provide survival risk prediction for colorectal cancer. Differential methylation analysis was performed on 309 colorectal cancer and 38 adjacent cancer specimens from the Cancer Genome Atlas (TCGA). Results: 2113 hypermethylation sites as well as 723 hypomethylation sites were screened out and 16 related CpG methylation loci were further identified. The risk score was calculated based on the methylation sites identified and utilized as an independent prognostic variable for multivariate Cox regression prediction model, which was further optimized by the independent prognostic factors (including stage and risk score). Conclusion: This study has identified several potential prognostic biomarkers and established a CpG-based prognostic prediction model for colorectal cancer, which provides a valuable reference for future clinical research.

show abstract

Genetic aberrations of the K-ras proto-oncogene in bladder cancer in relation to pesticide exposure

Cited by 10 publications

References 36 publications

A Review of Cancer Genetics and Genomics Studies in Africa

A Review of Cancer Genetics and Genomics Studies in Africa

Genetic and Epigenetic Alterations Induced by Pesticide Exposure: Integrated Analysis of Gene Expression, microRNA Expression, and DNA Methylation Datasets

A 16-CpG-based Prognostic Signature for Colorectal Cancer

Contact Info

Product

Resources

About