Genetic abberations in gallbladder cancer

Maurya, Sanjeev Kumar; Tewari, Mallika; Mishra, Ritusha; Shukla, H. S.

doi:10.1016/j.suronc.2010.09.003

Cited by 43 publications

(28 citation statements)

References 56 publications

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“…The high incidence of GBC in the Gangetic belt is a big challenge for us to explore the association of risk factors for GBC at the genetic level. We have published a number of original basic research papers in the subject [29][30][31][32][33][34][35]. However, not much work has been done on epigenetic changes that could be involved in the etiopathogenesis of GBC.…”

Section: Introductionmentioning

confidence: 99%

Epigenetic Changes in Carcinogenesis of Gallbladder

Tewari

Agarwal

Mishra

et al. 2013

Indian J Surg Oncol

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Gallbladder cancer (GBC) is a lethal and a common malignancy affecting mostly females. There are restricted high incidence pockets across the world and in northern India highest incidence of GBC is reported from the Gangetic belt. The etiology of this disease remains largely unknown though several risk factors have been stated. The genetic aberrations in GBC involving mutations in tumor suppressor genes and oncogenes have been reported in literature. However, there is scarcity of data regarding epigenetic changes that may also be involved in gallbladder carcinogenesis. This review attempts to summarize our current understanding of the epigenetic changes in GBC.

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Section: Introductionmentioning

confidence: 99%

Epigenetic Changes in Carcinogenesis of Gallbladder

Tewari

Agarwal

Mishra

et al. 2013

Indian J Surg Oncol

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“…The 5-year survival rate for GBC is 32% and for the advanced stage it is only 10% [9]. Current studies have focused on the importance of oncogenes (EGFR, HER-2, K-ras), tumor suppressor genes (p53, FHIT), cell cycle regulators (cyclin D, cyclin E), and micro-RNAs in the development and prognosis of GBC [10]. HER-2 expression evaluation as a biomarker for non-breast cancers has been gaining importance [11].…”

Section: Introductionmentioning

confidence: 99%

“…HER-2 expression evaluation as a biomarker for non-breast cancers has been gaining importance [11]. Among the array of responsible genes, one of the most flagrant genetic aberrations was ascribed to HER-2 in GBC [10]. Yan et al [12] reported that HER-2 overexpression was detected predominantly in malignancies of epithelial origin.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Significance of HER-2 and p53 Expression in Gallbladder Carcinoma in North Indian Patients

et al. 2016

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Background/Objective: Proto-oncogenes (HER-2) and tumor suppressor genes (p53) are commonly deregulated in gallbladder cancer (GBC). Available literature discloses skewed data from endemic Asian countries, especially north India. This study evaluates the prognostic significance of HER-2 and p53 in GBC patients from two major hospitals. Methods: Sixty resectable tumor and control specimens were prospectively collected from December 2012 to January 2016. Immunohistochemical staining was done using monoclonal antibodies to semiquantitatively evaluate HER-2 and p53 protein expression. The criterion for HER-2 positivity was set at >30% tumor cells showing complete, membranous staining while p53 positivity was established at <50% tumor cells showing complete nuclear staining. Clinicopathological correlations were drawn with major clinical outcomes. Results: It was observed that 36.67% (22/60) tumor cases and 5% (3/60) control cases showed strong HER-2 overexpression significantly correlating with sex, T-stage, nodal spread and distant metastasis (p < 0.05), while 33.3% (20/60) positivity was observed for p53 in tumor cases and 1.7% (1/60) in control cases. Multivariate analysis showed HER-2 (p = 0.04; hazard ratio: 2.36; 95% confidence interval: 1.04-5.33) and p53 (p = 0.03; hazard ratio: 5.63; 95% confidence interval: 1.21-26.26) expression to be independent prognostic factors. Conclusion: Our study thus suggests the plausible role of HER-2 and p53 expression in worse prognosis of GBC in a north Indian population.

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“…Postoperative adjuvant therapy, such as chemotherapy and radiation therapy, had no effect on the prognosis of ACs and SCs/ASCs [3]. Although some molecular markers have been identified to be associated with the tumorogenesis and prognosis of AC [8], no biomarkers have been identified in SC/ASC, particularly a comparative study of molecular markers between AC and SC/ASC has not been reported.…”

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confidence: 99%

A Comparative study of clinicopathological significance, BIRC7, and STC2 expression between squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder

Yuan¹,

Yang²,

Zou³

et al. 2014

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Gallbladder cancers (GBCs) are uncommon, but highly aggressive cancers. The majority of GBCs are adenocarcinomas (ACs), but rare subtypes of GBCs such as squamous cell carcinoma (SC) and adenosquamous carcinoma (ASC) are observed as well. The clinicopathological characteristics of SC/ASC have not been well documented. Expressions of BIRC7 and STC2 were observed in some tumors. However, BIRC7 and STC2 expressions and clinical significances in gallbladder cancer have not been reported.In this study, the protein expressions of BIRC7 and STC2 in 46 SCs/ASCs and 80 ACs were measured using immunohistochemistry.We demonstrated that positive BIRC7 and STC2 expressions were significantly associated with large tumor mass (>3cm), high TNM stage and lymph node metastasis in SC/ASC and AC (p<0.05). Positive expression of BIRC7 was significantly associated with invasion of around tissues and organs in both SC/ASC and AC. Additionally, negative BIRC7 and STC2 expressions were significantly associated with surgical curability in AC. Univariate Kaplan-Meier analysis showed that BIRC7 and STC2 expressions, differentiation, tumor size, TNM stages, invasion, lymph node metastasis, and surgical curability were significantly associated with post-operative survival in both SC/ASC and AC patients(p < 0.001). Multivariate Cox regression analysis showed that positive BIRC7 and STC2 expressions are independent poor-prognostic factors in both SC/ASC and AC patients.Our study suggested that positive BIRC7 and STC2 expressions are closely correlated with clinical, pathological, and biological behaviors as well as poor-prognosis of gallbladder cancer.

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Genetic abberations in gallbladder cancer

Cited by 43 publications

References 56 publications

Epigenetic Changes in Carcinogenesis of Gallbladder

Epigenetic Changes in Carcinogenesis of Gallbladder

Prognostic Significance of HER-2 and p53 Expression in Gallbladder Carcinoma in North Indian Patients

A Comparative study of clinicopathological significance, BIRC7, and STC2 expression between squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder

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