Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.

Spies, Thomas A.; Morton, Cynthia C.; Nedospasov, Sergei A.; Fiers, Walter; Pious, Donald; Strominger, Jack L.

doi:10.1073/pnas.83.22.8699

Cited by 278 publications

(102 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The genes for both TNF-alpha and TNF-beta are separated by about I kb of DNA on chromosome 6 within the major histocompatibility complex (Nedwin et al, 1985a;Spies et al, 1986). The expression of TNF mRNA encodes a precursor of 233 amino acids that is processed to a mature non-glycosylated protein of 17,300 Da containing a single disulphide linkage (Wang et al, 1985).…”

Section: General Properties Of Tnfmentioning

confidence: 99%

Tumour necrosis factor: a cytokine with multiple biological activities

Semenzato

1990

Br J Cancer

View full text Add to dashboard Cite

Section: General Properties Of Tnfmentioning

confidence: 99%

Tumour necrosis factor: a cytokine with multiple biological activities

Semenzato

1990

Br J Cancer

View full text Add to dashboard Cite

“…TNF-a, a cytokine with pleiotropic effects, satisfies the four candidate criteria alluded to above (for reviews, see Jaattela, 1991;Vilcek and Lee, 1991). TNF-a maps to the D region of the H-2 complex (Muller et al, 1987); it also maps to the human HLA region on the short arm of chromosome 6 (Spies et al, 1986). The TNF-a gene is polymorphic and this polymorphism is associated with differences in the level of TNF-a protein expression (Jacob and McDevitt, 1988) and with H-2 haplotype differences (Freund et al, 1992).…”

mentioning

confidence: 99%

Tumor necrosis factor‐α and embryonic mouse lung morphogenesis

Jaskoll

Boyer

Melnick

1994

Developmental Dynamics

View full text Add to dashboard Cite

The ontogeny of the embryonic and fetal lung involves complex interactions between epithelial and mesenchymal primordia which require a specific program of gene regulation and signal transduction. Past studies in our laboratory using congenic mouse strains indicate that one or more genes which map to the H-2 region of chromosome 17 regulate the rate of lung morphogenesis, defined in this context as differentiative heterochrony among strains. Since hormones and growth factors are the messengers of morphogenesis, it was logical to propose that tumor necrosis factor-a (TNF-a), a well-characterized cytokine whose gene maps to the D-region of the H-2 complex, is a putative mediator of lung morphogenesis. We investigated this proposition using immunochemical methods and a serumless, chemically defined in vitro model system. Our results demonstrate that: (1) TNF-a has a specific spatiotemporal localization, in vivo and in vitro; (2) TNF-a receptor, in vivo and in vitro, is localized throughout the embryonic lung; (3) TNF-a supplementation in vitro of embryonic lung primordia has a marked dose-dependent, stimulatory effect on branching morphogenesis and surfactant-associated protein (SP-A) expression; (4) multiple immunoreactive proteins, including 17,26, and 68 kDa species, are expressed during development in vivo, and a subset of these are expressed in vitro; and (5) both time-and glucocorticoid-dependent changes occur in the in vivo expression pattern of TNF-a immunoreactive proteins after 4 and 7 days in vitro, including the up-regulation of a novel 40 kDa protein. Given that glucocorticoids (CORT) regulate TNF-a expression and TNF-a's ability to stimulate pulmonary morphodifferentiation and histodifferentiation, we conclude that TNF-a is an autocrine/paracrine pulmonary cytokine, probably a component of the lung morphogenesis pathway regulated by CORT. o 1994 WiIey-Liss, Inc.

show abstract

“…(Spies et al, 1986;Carroll et al, 1987;Ziegler et al, 1991). The primary transcript of human TNF-a consists of 2,762 bp which has four exons and three introns (Nedwin et al, 1985;Nedospasov et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

NcoI restriction fragment length polymorphism at — 308 of the tumor necrosis factor alpha (TNFA) promoter region in korean

Park

Kim²,

Mok

1997

Jap J Human Genet

View full text Add to dashboard Cite

SummaryTumor necrosis factor alpha (TNFA) is a cytokine, which is secreted from activated macrophage, with a broad range of biological activities. The gene encoding TNFA is located in tandem with the TNFB gene within the HLA complex on chromosome 6p21.3. We detected a single base polymorphism in the human TNFA gene promoter region in 300 unrelated Korean individuals. The TNFA promoter region which showed a G to A transition at position of -308 was investigated by NcoI restriction fragment length polymorphism analysis. A biallelic polymorphism of TNFA gene showed fragments of 87/20 bp and 107 bp acting as TNFA* 1 allele and TNFA*2 allele, respectively. The allele frequencies of TNFA* 1 and TNFA* 2 were 0.8783 and 0.1217, respectively. The 21.7% of heterozygosity was observed. No association between promoter region phenotypes of TNFA and the first intron phenotypes of TNFB was observed in Korean. Allele frequencies of Koreans were compared with that of Europeans.

show abstract

Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.

Cited by 278 publications

References 30 publications

Tumour necrosis factor: a cytokine with multiple biological activities

Tumour necrosis factor: a cytokine with multiple biological activities

Tumor necrosis factor‐α and embryonic mouse lung morphogenesis

NcoI restriction fragment length polymorphism at — 308 of the tumor necrosis factor alpha (TNFA) promoter region in korean

Contact Info

Product

Resources

About