NcoI restriction fragment length polymorphism at — 308 of the tumor necrosis factor alpha (TNFA) promoter region in korean

Park, Kyoung Sook; Kim, Minyoung; Mok, Jeewon

doi:10.1007/bf02766929

Cited by 8 publications

(6 citation statements)

References 17 publications

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“…Haplotype and genotype in Iran 0Á05 (significant heterogeneity between the Iranian and the other East-South Asian populations). a Iranian, n ¼ 40 (our finding); b Taiwan, n ¼ 50(Trejaut et al, 2004); c Korean, n ¼ 300(Park et al, 1997); d Korean, n ¼ 57(Louie et al, 2002);…”

mentioning

confidence: 48%

“… * P < 0·001, ** P < 0·01, *** P < 0·05 (significant heterogeneity between the Iranian and the other East‐South Asian populations). a Iranian, n = 40 (our finding); b Taiwan, n = 50 (Trejaut et al ., 2004); c Korean, n = 300 (Park et al ., 1997); d Korean, n = 57 (Louie et al ., 2002); e Japanese, n = 70 (Kawaguchi et al ., 2003); f Japanese, n = 114 (Kato et al ., 2001); g Japanese, n = 575 (Higuchi et al ., 1998); h Japanese, n = 215 (Noguchi et al ., 1998); i Other Chinese, n = 88 (Mok et al ., 1998); j Singapore Chinese, n = 83 (Meenagh et al ., 2002). …”

Section: Resultsmentioning

confidence: 99%

“…This study analysed the frequency distribution of 22 SNPs in promoter regions of 13 cytokine gene polymorphisms (IL‐1α, IL‐1β, IL‐12, IFN‐γ, TGF‐β, TNF‐α, IL‐2, IL‐4, IL‐6, IL‐10, IL‐1R, IL‐1RA and IL‐4RA). We compared the allele and genotype frequencies in Iran with those in other Asian and non‐Asian populations (Table 1) (Park et al ., 1997; Higuchi et al ., 1998; Mok et al ., 1998; Noguchi et al ., 1998; Cox et al ., 2001; Kato et al ., 2001; Louie et al ., 2002; Meenagh et al ., 2002; Costeas et al ., 2003; Kawaguchi et al ., 2003; Trejaut et al ., 2004). All possible alleles were detected, and statistically distinct differences in the cytokine allelic and genotypic distributions were observed between the Iranian and other Asian populations (Tables 1 and 2).…”

Section: Discussionmentioning

confidence: 99%

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Heterogeneity of cytokine single‐nucleotide polymorphisms among the Iranian and in the other East‐South Asian populations

Bagheri¹,

Rad²,

Omrani³

et al. 2006

Transfusion Medicine

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Cytokine gene polymorphisms may affect their transcription, influence their level of production and may be implicated in inducing susceptibility or resistance to diseases. In 40 Iranian healthy subjects, cytokine single-nucleotide polymorphisms (SNPs) were used to determine allelic and genotypic frequencies for the following cytokine genes: IL-1a (T/C -889), IL-1beta (C/T -511, T/C 3962), IL-12 (C/A -1188), IFN-gamma (A/T UTR 5644), TGF-beta (C/T codon 10, G/C codon 25), TNF-a (G/A -308, G/A -238), IL-2 (T/G -330, G/T 166), IL-4 (T/G -1089, T/C -590, T/C -33), IL-6 (G/C -174, G/A nt565), IL-10 (G/A -1082, C/T -819, C/A -592), IL-1R (C/T pst11970), IL-1RA (T/C mspa111100) and IL-4RA (G/A 1902). All typing were performed with polymerase chain reaction with sequence specific primers assay. Significant heterogeneity of cytokine SNPs among the Iranian and the other East-South Asian populations was observed. Heterogeneity of cytokine SNPs may explain the role of natural selection in susceptibilities of populations to different disorders.

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confidence: 48%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Heterogeneity of cytokine single‐nucleotide polymorphisms among the Iranian and in the other East‐South Asian populations

Bagheri¹,

Rad²,

Omrani³

et al. 2006

Transfusion Medicine

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show abstract

“…TNF-α 의 발현은 염색체 6번에 위치한 TNF-α 유전자 촉진자(promoter) 부위의 단일염기다형성(single nucleotide polymorphism)에 의해 전사(transcription) 단계에서 조절된다고 알려져 있다 11) . 이렇게 특정 부위의 염기서열 1개가 다른 염기로 치환되면서 TNF-α 생산능을 높인다고 알려져 있는 부위의 대 립유전자(allele)로는 -1031C, -857T, -308A, -238A가 대표적 이다 [12][13][14] . TNF-α-238 위치의 대립유전자가 adenine일 때 BPD 발생의 위험성과 중증도가 감소한다는 보고가 있었고 15) TNF-α 유전자 다형성과 BPD 발생 사이에는 연관성이 없다는 상반되 는 연구도 있었다 16,17) .…”

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Association between Tumor Necrosis Factor-α Gene Polymorphism and Bronchopulmonary Dysplasia in Preterm Infants

Chang²,

Kim

et al. 2011

J Korean Soc Neonatol

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Purpose: Several factors including prolonged inflammatory response are thought to contribute to the pathogenesis of bronchopulmonary dysplasia (BPD). The clinical findings can be explained by an increased production of proinflammatory cytokines such as tumor necrosis factor alpha (TNF-α). We investigated the relationship between susceptibility to BPD and TNF-α promoter polymorphisms to identify genetic factors of the disease. Methods: Thirty-eight preterm infants who had developed BPD and 55 controlled infants with a birth weight <1,500 g were analyzed for TNF-α genotypes. The alleles of five promoter sites (-1031/-863/-857/-308/-238) of TNF-α gene were determined using Taqman ® -based allelic discrimination assays.Results: Gestational age (27 +5 ±2 +0 wk vs. 29 +2 ±1 +4 wk, P<0.0001) and birth weight (990±270 g vs. 1,220±230 g, P<0.0001) were lower in the BPD group compared to the control group. The incidence of respiratory distress syndrome (71.1% vs. 49.1%, P=0.035) and patent ductus arteriosus (71.1% vs. 50.9%, P=0.052) was higher in the BPD group compared to the control group. The frequencies of the alleles and genotypes of five promoter sites (-1031/-863/-857/-308/-238) of TNF-α gene did not show differences between the BPD group and the control group. Conclusion: TNF-α promoter polymorphisms are not associated with susceptibility to BPD in Korean preterm infants.

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“…- Louie et al (2002); b Park et al (1997); c Higuchi et al (1998) population. The genotype frequencies were also similar to that in Italian population, but different from that in African American population.…”

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confidence: 99%

Th1 and Th2 cytokine gene polymorphisms in two indigenous ethnic groups in Iran

Amirzargar

Sadeghi

Khosravi

et al. 2006

Int J Immunogenetics

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Cytokines are important immunomodulatory molecules in immune responses against microorganisms and also have an important role in the setting of disorders affecting immune system. Cytokine single nucleotide polymorphisms have been extensively studied in different normal populations as well as in relation to diseases. Some of these polymorphisms (SNP) affect cytokine gene transcription and expression. The polymorphisms of cytokine genes are potentially important as genetic predictors of the disease susceptibility and clinical outcome or as a tool for anthropological studies. In this study, samples have been collected from 261 healthy individuals located in two different regions of Iran (Tehran and Yazd). The allele and genotype frequencies of Th1 and Th2 cytokines SNP including interleukin (IL)-2, IL-4, IL-6, IL-10, tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma have been investigated, using the polymerase chain reaction-sequence-specific primer method. The allele and genotype frequencies in Tehran and Yazd populations were similar except for the IL-2, IL-4, IL-6 and IL-10. The IL-4 C allele, C/C -33 and T/T -1098 genotype were significantly more frequent in Tehran than in Yazd population (P = 0.04, P = 0.004 and P = 0.001, respectively). The G/A genotype of the IL-6 (nt565) and IL-10 (-1082) was significantly less frequent in Tehran than in Yazd population (P = 0.01 and P = 0.003, respectively). The GT haplotype of the IL-2 (-330, +166) was significantly less frequent in Tehran than in Yazd population (P = 0.0002). We have also compared our whole samples with the reported data from other countries showing that Iranian population have cytokine gene polymorphism profile similar to that of Caucasians, especially Italian population.

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NcoI restriction fragment length polymorphism at — 308 of the tumor necrosis factor alpha (TNFA) promoter region in korean

Cited by 8 publications

References 17 publications

Heterogeneity of cytokine single‐nucleotide polymorphisms among the Iranian and in the other East‐South Asian populations

Heterogeneity of cytokine single‐nucleotide polymorphisms among the Iranian and in the other East‐South Asian populations

Association between Tumor Necrosis Factor-α Gene Polymorphism and Bronchopulmonary Dysplasia in Preterm Infants

Th1 and Th2 cytokine gene polymorphisms in two indigenous ethnic groups in Iran

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