Genes encoding cuticular proteins are components of the Nimrod gene cluster in Drosophila

Cinege, Gyöngyi; Zsámboki, János; Vidal-Quadras, Maite; Uv, Anne; Csordás, Gábor; Honti, Viktor; Gábor, Erika; Hegedűs, Zoltán; Varga, Gergely I. B.; Kovács, Attila; Juhász, Gábor; Williams, Michael J.; Andó, István; Kurucz, Éva

doi:10.1016/j.ibmb.2017.06.006

Cited by 18 publications

(13 citation statements)

References 43 publications

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“…The vajk-1 gene is located within the Nimrod gene cluster on chromosome 2, the largest syntenic unit in the genome ( Somogyi et al 2010 ; Cinege et al 2017 ). Genes of the Nimrod cluster have been suggested to contribute to innate immune response ( Kurucz et al 2007 ).…”

Section: Resultsmentioning

confidence: 99%

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Regulators of Long-Term Memory Revealed by Mushroom Body-Specific Gene Expression Profiling in Drosophila melanogaster

et al. 2018

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Memory formation is achieved by genetically tightly controlled molecular pathways that result in a change of synaptic strength and synapse organization. While for short-term memory traces, rapidly acting biochemical pathways are in place, the formation of long-lasting memories requires changes in the transcriptional program of a cell. Although many genes involved in learning and memory formation have been identified, little is known about the genetic mechanisms required for changing the transcriptional program during different phases of long-term memory (LTM) formation. With Drosophila melanogaster as a model system, we profiled transcriptomic changes in the mushroom body—a memory center in the fly brain—at distinct time intervals during appetitive olfactory LTM formation using the targeted DamID technique. We describe the gene expression profiles during these phases and tested 33 selected candidate genes for deficits in LTM formation using RNAi knockdown. We identified 10 genes that enhance or decrease memory when knocked-down in the mushroom body. For vajk-1 and hacd1—the two strongest hits—we gained further support for their crucial role in appetitive learning and forgetting. These findings show that profiling gene expression changes in specific cell-types harboring memory traces provides a powerful entry point to identify new genes involved in learning and memory. The presented transcriptomic data may further be used as resource to study genes acting at different memory phases.

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Section: Resultsmentioning

confidence: 99%

“…However, vajk genes are not related to the Nimrod genes, which are involved in the innate immune defense. The vajk gene members are conserved in insects, but their function is unknown ( Somogyi et al 2010 ; Cinege et al 2017 ). Our results suggest that vajk-1 could be involved in the memory formation process.…”

Section: Discussionmentioning

confidence: 99%

Regulators of Long-Term Memory Revealed by Mushroom Body-Specific Gene Expression Profiling in Drosophila melanogaster

et al. 2018

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“…NimC1 was initially identified as an antigen for the plasmatocyte specific monoclonal antibody P1. It belongs to the Nimrod gene family that has been implicated in the cellular innate immune response in Drosophila [46], [47]. A previous study pointed to the importance of NimC1 in the phagocytosis of bacteria, since RNAi-mediated silencing of this gene resulted in decreased S.…”

Section: Discussionmentioning

confidence: 99%

Two Nimrod receptors, NimC1 and Eater, synergistically contribute to bacterial phagocytosis inDrosophila melanogaster

Melcarne

Ramond

Dudzic

et al. 2018

Preprint

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Eater and NimC1 are transmembrane receptors of the Drosophila Nimrod family, specifically expressed in hemocytes, the insect blood cells. Previous ex vivo and in vivo RNAi studies have pointed to their role in the phagocytosis of bacteria. Here, we have created a novel null mutant in NimC1 to re-evaluate the role of NimC1, alone or in combination with Eater, in the cellular immune response. We show that NimC1 functions as an adhesion molecule ex vivo, but in contrast to Eater is not required for hemocyte sessility in vivo. Ex vivo phagocytosis assays and electron microscopy experiments confirmed that Eater is the main phagocytic receptor for

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“…The vajk-1 gene is located within the Nimrod gene cluster on chromosome 2, the largest syntenic unit in the genome (Somogyi et al 2010; Cinege et al 2017). Genes of the Nimrod cluster have been suggested to be contributing to innate immune response (Kurucz et al 2007).…”

Section: Resultsmentioning

confidence: 99%

Mushroom body-specific profiling of gene expression identifies regulators of long-term memory inDrosophila

Widmer

Bilican

Bruggmann

et al. 2017

Preprint

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Genes encoding cuticular proteins are components of the Nimrod gene cluster in Drosophila

Cited by 18 publications

References 43 publications

Regulators of Long-Term Memory Revealed by Mushroom Body-Specific Gene Expression Profiling in Drosophila melanogaster

Regulators of Long-Term Memory Revealed by Mushroom Body-Specific Gene Expression Profiling in Drosophila melanogaster

Two Nimrod receptors, NimC1 and Eater, synergistically contribute to bacterial phagocytosis inDrosophila melanogaster

Mushroom body-specific profiling of gene expression identifies regulators of long-term memory inDrosophila

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