Generation of potentially bioactive ergosterol-derived products following pulsed ultraviolet light exposure of mushrooms (Agaricus bisporus)

Kalaras, Michael D.; Beelman, Robert B.; Holick, Michael F.; Elias, Ryan J.

doi:10.1016/j.foodchem.2012.04.132

Cited by 53 publications

(39 citation statements)

References 38 publications

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“…2B). These findings in irradiated mushrooms are similar to what was observed in irradiated ampoules containing provitamin D 2 and confirms the previous observations by Kalaras et al 13 (Fig. 2C and D).…”

Section: Photoproduction Of Previtamin D2 In Mushroomssupporting

confidence: 92%

“…A similar result was observed in irradiated ampoules; previtamin D 2 , lumisterol 2 and tachysterol 2 were detected (Fig. 2C and D) and confirms a previous report 13 …”

Section: Photoproduction Of Lumisterol 2 and Tachysterolsupporting

confidence: 92%

“…Previtamin D 2 can absorb UVB radiation resulting in the production of the photobyproducts, lumisterol 2 and tachysterol 2 13 . An evaluation of the thermal isomerization of previtamin D 2 to vitamin D 2 in mushrooms revealed that it was rapidly converted to vitamin D 2 most likely by a non-enzymatic membrane-enhanced catalytic mechanism similar to what was observed in lizard and human skin 14 , 29 .…”

Section: Resultsmentioning

confidence: 74%

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Photobiology of vitamin D in mushrooms and its bioavailability in humans

Keegan

Zhang

Bogusz

et al. 2013

Dermato-Endocrinology

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112

115

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Mushrooms exposed to sunlight or UV radiation are an excellent source of dietary vitamin D2 because they contain high concentrations of the vitamin D precursor, provitamin D2. When mushrooms are exposed to UV radiation, provitamin D2 is converted to previtamin D2. Once formed, previtamin D2 rapidly isomerizes to vitamin D2 in a similar manner that previtamin D3 isomerizes to vitamin D3 in human skin. Continued exposure of mushrooms to UV radiation results in the production of lumisterol2 and tachysterol2. It was observed that the concentration of lumisterol2 remained constant in white button mushrooms for up to 24 h after being produced. However, in the same mushroom tachysterol2 concentrations rapidly declined and were undetectable after 24 h. Shiitake mushrooms not only produce vitamin D2 but also produce vitamin D3 and vitamin D4. A study of the bioavailability of vitamin D2 in mushrooms compared with the bioavailability of vitamin D2 or vitamin D3 in a supplement revealed that ingestion of 2000 IUs of vitamin D2 in mushrooms is as effective as ingesting 2000 IUs of vitamin D2 or vitamin D3 in a supplement in raising and maintaining blood levels of 25-hydroxyvitamin D which is a marker for a person's vitamin D status. Therefore, mushrooms are a rich source of vitamin D2 that when consumed can increase and maintain blood levels of 25-hydroxyvitamin D in a healthy range. Ingestion of mushrooms may also provide the consumer with a source of vitamin D3 and vitamin D4.

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Section: Photoproduction Of Previtamin D2 In Mushroomssupporting

confidence: 92%

“…A similar result was observed in irradiated ampoules; previtamin D 2 , lumisterol 2 and tachysterol 2 were detected (Fig. 2C and D) and confirms a previous report 13 …”

Section: Photoproduction Of Lumisterol 2 and Tachysterolsupporting

confidence: 92%

Section: Resultsmentioning

confidence: 74%

See 1 more Smart Citation

Photobiology of vitamin D in mushrooms and its bioavailability in humans

Keegan

Zhang

Bogusz

et al. 2013

Dermato-Endocrinology

Self Cite

112

115

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“…The conversion of ergosterol to vitamin D 2 via UV radiation has a long history of commercial use for vitamin D 2 production for dietary supplements, pharmaceutical grade vitamin D preparations, and food fortification [37]. A few studies have reported the successful conversion of ergosterol to vitamin D 2 in mushrooms via UV irradiation [38, 39]. According to Ma et al [40], ergosterol isolated from Inonotus obliquus was found to possess anti-inflammatory activities.…”

Section: Discussionmentioning

confidence: 99%

Amauroderma rugosum(Blume & T. Nees) Torrend: Nutritional Composition and Antioxidant and Potential Anti-Inflammatory Properties

Chan

Kanagasabapathy

Tan

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Amauroderma rugosum is a wild mushroom that is worn as a necklace by the indigenous communities in Malaysia to prevent fits and incessant crying by babies. The aim of this study was to investigate the nutritive composition and antioxidant potential and anti-inflammatory effects of A. rugosum extracts on LPS-stimulated RAW264.7 cells. Nutritional analysis of freeze-dried mycelia of A. rugosum (KUM 61131) from submerged culture indicated a predominant presence of carbohydrates, proteins, dietary fibre, phosphorus, potassium, and sodium. The ethanol crude extract (EE), its hexane (HF), ethyl acetate (EAF), and aqueous (AF) fractions of mycelia of A. rugosum grown in submerged culture were evaluated for antioxidant potential and anti-inflammatory effects. EAF exhibited the highest total phenolic content and the strongest antioxidant activity based on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays. HF showed dose-dependent inhibition of NO production in LPS-stimulated RAW264.7 cells and NO radical scavenging activity. Gas chromatographic analysis of HF revealed the presence of ethyl linoleate and ergosterol, compounds with known anti-inflammatory properties. In conclusion, the nutritive compositions and significant antioxidant potential and anti-inflammatory effects of mycelia extracts of A. rugosum have the potential to serve as a therapeutic agent or adjuvant in the management of inflammatory disorders.

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“…Mushrooms produce vitamin D 2 , or ergocalciferol, when exposed to sunlight or ultraviolet radiation, in a similar process by which humans produce vitamin D 3 , or cholecalciferol. Not all plants possess this property, but fungi, seaweed, and yeast do (Kalaras et al 2012).…”

Section: Sources Of Vitamin Dmentioning

confidence: 99%