Generation of potent antioxidant nanoparticles from mango leaves by supercritical antisolvent extraction

Guamán-Balcázar, M.C.; Montes, A.; Férnandez-Ponce, M.T.; Casas, Lourdes; Mantell, Casimiro; Pereyra, C.; Ossa, E.J. Martı́nez de la

doi:10.1016/j.supflu.2018.04.005

Cited by 17 publications

(9 citation statements)

References 40 publications

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“…The implementation of enhanced solvent extraction (ESE) using co-solvent mixtures has proven to be effective for this purpose [20]. Among the high-pressure extraction techniques, ESE stands out as a selective process for the extraction of polyphenols that also reduces the use of organic solvents, the extraction time and the concentration steps that may cause the degradation of the antioxidant compounds [18,23,25]. On the other hand, the use of co-solvent contributes to an augmentation of the magnitude of dipole-dipole, induced dipole-dipole and induced dipole-induced dipole interactions between the solute and the solvent molecules, which results in an overall enhancement of solubility [26].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of Different Co-Solvent Mixtures on the Supercritical CO2 Extraction of the Phenolic Compounds Present in Moringa oleifera Lam. Leaves

et al. 2022

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Supercritical fluid extraction (SFE), using CO2, is a novel, sustainable and very efficient technique for the recovery of highly apolar compounds. However, the recovery of phenolic compounds requires the use of different co-solvent combinations such as water and ethanol to enhance the recovery of these compounds through the optimization of a number of variables. In this sense, the effect of pressure (100, 150 and 200 bar), temperature (50, 65 and 80 °C), extraction time (30, 60, 90, 120, 150 and 180 min) and the effect of the different percentages of ethanol and water as co-solvents on the composition and phenolic content of moringa leaf extracts were evaluated. Six major flavonoids were identified by ultra-high-performance liquid chromatography coupled to a quadrupole-time-of-flight mass spectrometer (UHPLC-Q-ToF-MS). Pressure and temperature had a significant effect on the phenolic composition of the extracts, as well as on their concentrations. The highest concentration of total flavonoids compounds (TFCs) was obtained by using a mixture of CO2 and water of 50:50 (v/v) at 100 bar, at 65 °C after a 120 min extraction time that produced a concentration of 11.66 mg ± 0.02 mg TFC g−1 sample, which corresponds to 89.0% of the total flavonoids of the sample, obtained by exhaustive extraction.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of Different Co-Solvent Mixtures on the Supercritical CO2 Extraction of the Phenolic Compounds Present in Moringa oleifera Lam. Leaves

et al. 2022

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“…Supercritical fluid extraction with CO 2 is an alternative non-toxic technique for extracting natural compounds at low temperatures with no use of contaminant solvents [39]. A related technique, named supercritical antisolvent extraction, can assist in overcoming the limited capacity of CO 2 to dissolve polar compounds [40], resulting in micro-and nanoparticle-sized products [41].…”

Section: Introductionmentioning

confidence: 99%

Croton lechleri Extracts as Green Corrosion Inhibitors of Admiralty Brass in Hydrochloric Acid

et al. 2021

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Croton lechleri, commonly known as Dragon’s blood, is a tree cultivated in the northwest Amazon rainforest of Ecuador and Peru. This tree produces a deep red latex which is composed of different natural products such as phenolic compounds, alkaloids, and others. The chemical structures of these natural products found in C. lechleri latex are promising corrosion inhibitors of admiralty brass (AB), due to the number of heteroatoms and π structures. In this work, three different extracts of C. lechleri latex were obtained, characterized phytochemically, and employed as novel green corrosion inhibitors of AB. The corrosion inhibition efficiency (IE%) was determined in an aqueous 0.5 M HCl solution by potentiodynamic polarization (Tafel plots) and electrochemical impedance spectroscopy, measuring current density and charge transfer resistance, respectively. In addition, surface characterization of AB was performed by scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy techniques. Chloroform alkaloid-rich extracts resulted in IE% of 57% at 50 ppm, attributed to the formation of a layer of organic compounds on the AB surface that hindered the dezincification process. The formulation of corrosion inhibitors from C. lechleri latex allows for the valorization of non-edible natural sources and the diversification of the offer of green corrosion inhibitors for the chemical treatment of heat exchangers.

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“…In this case, most polar polyphenolic compounds are practically insoluble in sc-CO2, but are sufficiently soluble in a sc-CO2 + EtOH mixture or in a sc-CO2 + EtOH-H2O mixture, leading to separation and/or distribution according to molecular weights and polarity [22]. The SAF technique has been successfully applied to produce nanoand microparticles of antioxidant polyphenolic compounds from mango by-products (peels and pulp wastes) [23] and mango leaves [24,25]. Furthermore, SAF has also been employed to improve fractions' bioactivity compared to the original feed extract, correlating the compounds-enrichment with the observed bioactivity.…”

Section: Introductionmentioning

confidence: 99%

Supercritical antisolvent fractionation as a tool for enhancing antiproliferative activity of mango seed kernel extracts against colon cancer cells

Ballesteros-Vivas

Álvarez-Rivera

Ocampo

et al. 2019

The Journal of Supercritical Fluids

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Mango seed kernel (MSK) has demonstrated to be a valuable source of bioactive phenolic compounds with antiproliferative activity against colon cancer cell lines. In this work, a phenolic MSK extract obtained by sequential pressurized liquid extraction (PLE) was submitted to supercritical antisolvent fractionation (SAF) to attain enriched fractions with improved inhibitory effect on HT-29 colon cancer cells. SAF was optimized using a Box-Behnken experimental design and considering as main factors: pressure, percentage of water in the feed extract and feed/sc-CO2 flow rate ratio; selected response variable was the inhibitory cell proliferation (%) and the SAF yield (%) measured in both, raffinates and extracts. The highest inhibitory cell proliferation effect (70.51 ± 1.14%) was obtained in the extract using 50% of water v/v in the feed and 0.0625 feed/sc-CO2 ratio at 15 MPa. This result represents an improvement in the antiproliferative activity by the SAF process compared to the original PLE extract. A targeted phytochemical profiling by LC-q-TOF-MS/MS followed by a multivariate statistical analysis of the observed bioactivity and the chemical composition evidenced the existence of a remarkable variability among the obtained SAF fractions, mainly due to characteristic compounds (e.g., mangiferin, homomangiferin, galloyl methylgallate, ellagic acid and methyl gallate), which might explain the enhanced antiproliferative activity of the optimal SAF extract.

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Generation of potent antioxidant nanoparticles from mango leaves by supercritical antisolvent extraction

Cited by 17 publications

References 40 publications

Evaluation of the Effect of Different Co-Solvent Mixtures on the Supercritical CO2 Extraction of the Phenolic Compounds Present in Moringa oleifera Lam. Leaves

Evaluation of the Effect of Different Co-Solvent Mixtures on the Supercritical CO2 Extraction of the Phenolic Compounds Present in Moringa oleifera Lam. Leaves

Croton lechleri Extracts as Green Corrosion Inhibitors of Admiralty Brass in Hydrochloric Acid

Supercritical antisolvent fractionation as a tool for enhancing antiproliferative activity of mango seed kernel extracts against colon cancer cells

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