Generation of Neuronal Diversity: Analogies and Homologies with Hematopoiesis

Nawa, Hiroyuki; Yamamori, Tetsuo; Le, Tsitolovskiĭ; Patterson, Paul H.

doi:10.1101/sqb.1990.055.01.027

Cited by 58 publications

(19 citation statements)

References 42 publications

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“…In addition, inactivation of STAT3 in vivo decreases survival of embryonic sensory neurons, thereby supporting the possibility of STAT3 involvement in sensory neuron survival after adult axotomy (Alonzi et al, 2001). Moreover, the injury-induced activation of STAT3 may help maintain sensory neuron neurochemical phenotype, in that treatment of embryonic (Nawa et al, 1990) and adult (Mulderry, 1994) DRG neurons in culture with STAT3-activating ligands has been shown to manipulate neurotransmitter levels. Fig.…”

Section: Peripheral Nerve Lesion and Stat3 In Sensory Neuronsmentioning

confidence: 94%

STAT3 phosphorylation in injured axons before sensory and motor neuron nuclei: Potential role for STAT3 as a retrograde signaling transcription factor

Lee

Neitzel

Devlin

et al. 2004

J of Comparative Neurology

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STAT3 is a latent transcription factor that is activated by plasma membrane growth factor receptor complexes. Conditional gene disruption data indicate that it contributes to the survival of cranial motor neurons after peripheral nerve lesion. In agreement, levels of activated STAT3 (Tyr705-phosphorylated STAT3) have been shown to increase in the nuclei of adult cranial motor neurons during their regeneration after the same injury. The data presented here demonstrate that STAT3 is similarly but not identically affected in sciatic motor neurons after sciatic nerve injury. In addition, we find that sensory neuron nuclei also display an analogous increase in activated STAT3, thereby supporting a role for STAT3 in the survival and regeneration of these cells. Most interesting, the present data indicate that peripheral nerve lesion leads to a very rapid activation of STAT3 in axons at the lesion site. This response increases during the first 24 hours after injury and extends back to the motor and sensory neurons such that phospho-STAT3-immunoreactive axons are first detected in the dorsal root ganglia and ventral spinal cord at the same postlesion time intervals at which the activated STAT3 is first detected in the neuronal nuclei. Together these data raise the possibility that axonal STAT3, activated at the injury site, acts as a retrograde signaling transcription factor, which promotes the survival and regeneration of both sensory and motor neurons.

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Section: Peripheral Nerve Lesion and Stat3 In Sensory Neuronsmentioning

confidence: 94%

STAT3 phosphorylation in injured axons before sensory and motor neuron nuclei: Potential role for STAT3 as a retrograde signaling transcription factor

Lee

Neitzel

Devlin

et al. 2004

J of Comparative Neurology

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“…SOM synthesis is induced by ciliary neurotrophic factor (CNTF) and CDF/LIF: as for ChAT, CDFILIF treatment results in higher SOM mRNA levels (Nawa et al, 1991). This effect is reversible and appears to be selective since SOM is not increased by this cytokine in sensory neurons (Nawa et al, 1990). On the other hand, SOM mRNA is reduced in sensory ganglia after axotomy (Noguchi et al, 1993).…”

Section: Opioidsmentioning

confidence: 97%

Localization, regulation and functions of neurotransmitters and neuromodulators in cervical sympathetic ganglia

Klimaschewski

Kummer

Heym

1996

Microsc. Res. Tech.

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“…In addition to cholinergic markers, the mature sweat gland innervation contains immunoreactivity for two neuropeptides, VIP and CGRP. VIP is induced in sympathetic neurons by cholinergic differentiation factors in vitro (Nawa et al, 1991;Rao and Landis, 1993) and by sweat glands in vivo (Schotzinger and Landis, 1990;Schotzinger et al, 1994).…”

Section: Catecholamines Are Not Required For the Appearance Of Cholinmentioning

confidence: 99%

Catecholamines Are Required for the Acquisition of Secretory Responsiveness by Sweat Glands

et al. 2000

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The sympathetic innervation of sweat glands undergoes a developmental change in transmitter phenotype from catecholaminergic to cholinergic. Acetylcholine elicits sweating and is necessary for development and maintenance of secretory responsiveness, the ability of glands to produce sweat after nerve stimulation or agonist administration. To determine whether catecholamines play a role in the development or function of this system, we examined the onset of secretory responsiveness in two transgenic mouse lines, one albino and the other pigmented, that lack tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis. Although both lines lack TH, their catecholamine levels differ because tyrosinase in pigmented mice serves as an alternative source for catecholamine synthesis (Rios et al., 1999). At postnatal day 21 (P21), 28 glands on average are active in interdigital hind footpads of albino TH wild-type mice. In contrast, fewer than one gland is active in albino TH null mice, which lack catecholamines in gland innervation. Treatment of albino TH null mice with DOPA, a catecholamine precursor, from P11 to P21 increases the number of active glands to 14. Pigmented TH null mice, which have faint catecholamine fluorescence in the developing gland innervation, possess 12 active glands at P21, indicating that catecholamines made via tyrosinase, albeit reduced from wild-type levels, support development of responsiveness. Gland formation and the appearance of cholinergic markers occur normally in albino TH null mice, suggesting that catecholamines act directly on gland cells to trigger their final differentiation and to induce responsiveness. Thus, catecholamines, like acetylcholine, are essential for the development of secretory responsiveness.

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Generation of Neuronal Diversity: Analogies and Homologies with Hematopoiesis

Cited by 58 publications

References 42 publications

STAT3 phosphorylation in injured axons before sensory and motor neuron nuclei: Potential role for STAT3 as a retrograde signaling transcription factor

STAT3 phosphorylation in injured axons before sensory and motor neuron nuclei: Potential role for STAT3 as a retrograde signaling transcription factor

Localization, regulation and functions of neurotransmitters and neuromodulators in cervical sympathetic ganglia

Catecholamines Are Required for the Acquisition of Secretory Responsiveness by Sweat Glands

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