“…Due to their lack of genetic mutations and genomic structural variation, including the absence of TCR/BCR gene recombination found in T cells, EPCs were selected for reprogramming [ 40 ]. We, therefore, established two DRVT-iPSC lines using a non-integrative and virus-free reprogramming approach as previously described [ 29 ]. Briefly, the episomal vectors encoding OCT4, SOX2, KLF4, L-MYC, LIN28A, dominant-negative form of TP53, and EBNA1 were delivered to EPCs by electroporation (Fig.…”